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公开(公告)号：US12292440B2
公开(公告)日：2025-05-06
申请号：US18653506
申请日：2024-05-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael L. Samuels , Darren Roy Link
IPC: G01N33/543 , B01F33/3011 , B01F33/302 , C12Q1/6874 , C40B30/04 , C40B40/00 , C40B40/04 , C40B70/00 , G01N33/532
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
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公开(公告)号：US20250121372A1
公开(公告)日：2025-04-17
申请号：US18901984
申请日：2024-09-30
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kevin D. NESS , Christopher F. KELLY , Donald A. MASQUELIER
IPC: B01L3/00 , B01F23/41 , B01F33/3011 , B01L3/02 , B01L7/00 , C12Q1/6806 , G01N35/00 , G01N35/08 , G01N35/10
Abstract: A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.
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公开(公告)号：US20250043362A1
公开(公告)日：2025-02-06
申请号：US18793760
申请日：2024-08-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Karlin-Neumann , Ronald Lebofsky , Mona Shahbazian , Mina Rostamza
IPC: C12Q1/6886 , C12Q1/6806 , C12Q1/6809 , C12Q1/686 , G01N21/64
Abstract: The invention provides methods for the detection of molecular targets by digital PCR (dPCR) with a blocker for non-target molecules. Each target is provided with a unique mixture of probes. The blocker binds to a non-target molecule and blocks it from contributing to fluorescence from partitions. Two or more colors of fluorescence intensity are read, and two colors of fluorescence intensity are plotted as a 2D plot. In the plot, different targets contribute well-resolved clusters. Each cluster in the plot essentially lies a long its own radius allowing for radial multiplexing. The use of a blocker selects against the detection of non-target molecules and improves the resolution of radial multiplexing, allowing multiple targets to be detected.
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公开(公告)号：US12180541B2
公开(公告)日：2024-12-31
申请号：US18106189
申请日：2023-02-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky
IPC: C12Q1/68 , C12Q1/6834 , C12Q1/6855
Abstract: Methods and compositions for attaching cell-specific barcodes without formation of partitions is provided.
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公开(公告)号：US20240385425A1
公开(公告)日：2024-11-21
申请号：US18785390
申请日：2024-07-26
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Frank HSIUNG , Kelly KROEGER , Robert ARCHER , Veronika KORTISOVA , Teresa RUBIO , Amber IRAETA
Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus.
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Patent Agency Ranking
公开(公告)号：US20240367143A1
公开(公告)日：2024-11-07
申请号：US18653214
申请日：2024-05-02
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SHAWN DARNALL , BRIAN PANGANIBAN , DANNI WANG , CHRISTOPHER BELISLE , ZACHARY CLAUSS
Abstract: Provided herein is a chromatography media composed of a porous solid substrate (such as a membrane, metal, or metallic alloy) that is coated with hydroxyapatite (IA). Also provided is a chromatography media comprising a HA-coated substrate and uses thereof. Thus this disclosure provides a chromatography media composed of a porous solid substrate (such as a membrane, metal, or metallic alloy) that is coated with I-IA. Also provided is a chromatography media comprising a HA-coated substrate and uses thereof. Methods of preparing the HA-coated substrate are also provided.
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公开(公告)号：US20240336949A1
公开(公告)日：2024-10-10
申请号：US18628860
申请日：2024-04-08
Applicant: BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHE QUIRING , CHRISTINE FAVIER , PATRICE SARFATI , JEAN FRANCOIS MOUSCADET , RONALD LEBOFSKY , REBECCA DIEVART
CPC classification number: C12Q1/06 , C12N9/2428 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/2474 , C12N9/485 , C12Q1/04 , C12Q1/045 , C12Y302/01003 , C12Y302/01022 , C12Y302/01035 , C12Y304/11
Abstract: Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.
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公开(公告)号：US20240327904A1
公开(公告)日：2024-10-03
申请号：US18619911
申请日：2024-03-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man CHENG , Qiang ZHANG , Linda HINH
IPC: C12Q1/6851 , C12Q1/6806
CPC classification number: C12Q1/6851 , C12Q1/6806
Abstract: Compositions and methods for fixing cells or nuclei or extracellular vesicles with dithiobismaleimidoethane (DTME) and subsequent reverse transcription in the cells or nuclei or extracellular vesicles are provided.
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公开(公告)号：US12103005B2
公开(公告)日：2024-10-01
申请号：US16995555
申请日：2020-08-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kevin D. Ness , Christopher F. Kelly , Donald A. Masquelier
IPC: B01L3/00 , B01F23/41 , B01F33/3011 , B01L3/02 , B01L7/00 , C12Q1/6806 , G01N35/00 , G01N35/08 , G01N35/10
CPC classification number: B01L3/502784 , B01F23/41 , B01F33/3011 , B01L3/502715 , B01L3/502723 , C12Q1/6806 , G01N35/085 , B01L3/0275 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2400/0487 , G01N2035/00148 , G01N2035/1034 , G01N35/1065 , Y10T29/494
Abstract: A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.
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公开(公告)号：US20240280569A1
公开(公告)日：2024-08-22
申请号：US18653506
申请日：2024-05-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael L. Samuels , Darren Roy Link
IPC: G01N33/543 , B01F33/3011 , B01F33/302 , C12Q1/6874 , C40B30/04 , C40B40/00 , C40B40/04 , C40B70/00 , G01N33/532
CPC classification number: G01N33/54366 , C12Q1/6874 , C40B40/00 , C40B40/04 , C40B70/00 , G01N33/532 , B01F33/3011 , B01F33/3021 , C40B30/04
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
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