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55 条记录 (耗时 0.025 秒)

    Multi-neural net imaging apparatus and method
    2.
    发明授权
    Multi-neural net imaging apparatus and method 有权
    多神经网络成像设备及方法

    公开(公告)号：US06947586B2

    公开(公告)日：2005-09-20

    申请号：US09841941

    申请日：2001-04-24

    申请人： Harvey L. Kasdan ,  Michael R. Ashe ,  Minn Chung

    发明人： Harvey L. Kasdan ,  Michael R. Ashe ,  Minn Chung

    IPC分类号： G01N33/493 ,  C12M1/00 ,  C12Q1/02 ,  G01N15/00 ,  G01N15/14 ,  G06K9/00 ,  G06T1/00 ,  G06T1/40 ,  G06T7/00

    CPC分类号： G01N15/1475 ,  G01N2015/008 ,  G01N2015/1488 ,  G06K9/00127

    摘要： A multi-neural net imaging apparatus and method for classification of image elements, such as biological particles. The multi-net structure utilizes subgroups of particle features to partition the decision space by an attribute or physical characteristic of the particle and/or by individual and group particle classification that includes an unknown category. Preprocessing and post processing enables heuristic information to be included as part of the decision making process. Preprocessing classifies particles as artifacts based on certain physical characteristics. Post processing enables the use of contextual information either available from other sources or gleaned from the actual decision making process to further process the probability factors and enhance the decisions.

    摘要翻译： 一种用于分类图像元素（如生物颗粒）的多神经网络成像设备和方法。 多网结构利用粒子特征的子群，通过粒子的属性或物理特征和/或包括未知类别的个体和群体粒子分类对决策空间进行分割。 预处理和后处理使启发式信息能够作为决策过程的一部分。 预处理根据某些物理特性将粒子分类为伪像。 后处理使得可以使用从其他来源获得的上下文信息或从实际决策过程中收集到的上下文信息来进一步处理概率因子并增强决策。

    System and method for dynamically securing dynamic-multi-sourced persisted EJBS
    3.
    发明授权
    System and method for dynamically securing dynamic-multi-sourced persisted EJBS 有权
    用于动态保护动态多源持久EJBS的系统和方法

    公开(公告)号：US06922695B2

    公开(公告)日：2005-07-26

    申请号：US10064975

    申请日：2002-09-05

    申请人： Jim Skufca ,  David Smith ,  Rob Bugh ,  John Buslawski

    发明人： Jim Skufca ,  David Smith ,  Rob Bugh ,  John Buslawski

    IPC分类号： G06F9/46 ,  H04L29/08 ,  G06F17/30

    CPC分类号： G06F9/465 ,  H04L67/02 ,  H04L67/142 ,  H04L69/329 ,  Y10S707/99945

    摘要： Dynamic Multi-sourced Persisted Enterprise Java Bean (EJB) instances are dynamically created on a J2EE compliant Application Server to access data contained in multiple data source systems. This Dynamic Multi-sourced Persisted EJB is a general class responsible for dynamically aggregating source system information and securing it based on a Context definition. Individual EJB attributes that include mapping, caching and security definitions are mapped to individual pieces of data in source systems by the Context definition. A Context definition can be reloaded during execution as desired. Applications can access the Dynamic Multi-sourced Persisted EJB directly, or use a Session EJB to create a static interface to the dynamically mapped, cached and secured data. Using an attribute securing element, a security engine enforces access requirements on a system-wide basis.

    摘要翻译： 动态多源持久企业Java Bean（EJB）实例在J2EE兼容应用服务器上动态创建，以访问多个数据源系统中包含的数据。 这种动态多源持久化EJB是一个通用类，负责动态聚合源系统信息并基于Context定义来保护它。 包括映射，缓存和安全定义的单个EJB属性通过Context定义映射到源系统中的各个数据片段。 可以根据需要在执行期间重新载入上下文定义。 应用程序可以直接访问动态多源持久化EJB，也可以使用Session EJB为动态映射缓存和安全数据创建静态接口。 使用属性保护元素，安全引擎在系统范围内实施访问要求。

    Chimeric pro-caspases and methods of using same
    4.
    发明授权
    Chimeric pro-caspases and methods of using same 失效
    嵌合前胱天蛋白酶及其使用方法

    公开(公告)号：US06916917B1

    公开(公告)日：2005-07-12

    申请号：US09441926

    申请日：1999-11-17

    申请人： David Baltimore ,  Xiaolu Yang ,  Howard Y. Chang

    发明人： David Baltimore ,  Xiaolu Yang ,  Howard Y. Chang

    IPC分类号： A61K38/48 ,  A61K39/395 ,  C07H21/04 ,  C12N9/64 ,  C12P21/06 ,  C12Q1/68

    CPC分类号： C12N9/6475 ,  C07H21/04 ,  C07K2319/00 ,  C07K2319/50

    摘要： The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a polynucleotide encoding a chimeric pro-caspase, and to nucleotide sequences, which can hybridize specifically with a polynucleotide encoding a chimeric pro-caspase. The present invention also relates to a method of inducing apoptosis in a cell by providing a chimeric pro-caspase in the cell, wherein the chimeric pro-caspase includes a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cell, thereby activating caspase activity of the chimeric pro-caspase and inducing apoptosis in the cell. The present invention further relates to a method of reducing the severity of a pathologic condition in a subject, by providing cells of the subject that are involved in the pathologic condition with a chimeric pro-caspase comprising a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cells, thereby activating caspase activity of the chimeric pro-caspase, inducing apoptosis in the cells, and reducing the severity of the pathologic condition in the subject.

    摘要翻译： 本发明涉及含有前半胱天冬酶蛋白酶结构域和寡聚化结构域的嵌合前半胱天冬酶。 本发明还涉及与嵌合亲胱天蛋白酶特异性反应的抗体。 此外，本发明还涉及编码嵌合型前半胱氨酸蛋白酶的多核苷酸以及可与编码嵌合型前半胱天冬酶的多核苷酸特异性杂交的核苷酸序列。 本发明还涉及通过在细胞中提供嵌合型前半胱氨酸蛋白酶诱导细胞凋亡的方法，其中所述嵌合前半胱氨酸蛋白酶包括前半胱天冬酶蛋白酶结构域和寡聚结构域，由此所述嵌合型前半胱天冬酶形成 从而激活嵌合前半胱氨酸蛋白酶的半胱天冬酶活性并诱导细胞凋亡。 本发明还涉及通过用包含前半胱天冬酶蛋白酶结构域和寡聚结构域的嵌合前半胱氨酸蛋白酶提供参与病理状况的受试者的细胞来降低受试者病理状况的严重性的方法， 由此嵌合的前半胱天冬酶在细胞中形成寡聚体，从而激活嵌合前半胱天冬酶的半胱天冬酶活性，诱导细胞凋亡，并降低受试者病理状况的严重性。

    Brain retraction sensor
    7.
    发明授权
    Brain retraction sensor 有权
    脑回缩传感器

    公开(公告)号：US06916294B2

    公开(公告)日：2005-07-12

    申请号：US10190638

    申请日：2002-07-09

    申请人： Michael Ayad

    发明人： Michael Ayad

    IPC分类号： A61B5/03 ,  A61B5/0478 ,  A61B5/103 ,  A61B5/117

    CPC分类号： A61B5/0478 ,  A61B5/031 ,  A61B5/4076 ,  A61B2562/0215

    摘要： An electrode grid device is disclosed comprising a deformable envelope, further comprising non-polarizable electrodes and a pressure recording port. The device is designed to allow for monitoring of brain retraction pressure and local cortical electrical activity including DC potential, as well as to redistribute the force applied during retraction and thereby diminish the chance of focal brain injury during surgery. Retraction pressure recorded is equal over the full area of contact, providing a more meaningful measurement than simply at one point on the retractor. A means is disclosed for evacuation of air from the system to improve accuracy and fidelity of the pressure measurements. It is a further aspect of the device to allow for measurement of intracranial pressure, DC potential and EEG in epileptic and severe head trauma patients for management of edema and injury, respectively.

    摘要翻译： 公开了一种电极栅格装置，其包括可变形外壳，还包括不可极化电极和压力记录端口。 该装置被设计为允许监测脑回缩压力和局部皮层电活动，包括DC电位，以及重新分布在收缩期间施加的力，从而减少手术中局部脑损伤的机会。 记录的收缩压力在整个接触区域相等，提供比简单的牵开器上的一个点更有意义的测量。 公开了一种用于从系统抽空空气以提高压力测量的精度和保真度的装置。 这是允许癫痫和严重头部创伤患者颅内压，直流电位和脑电图分别测量水肿和损伤的另一个方面。

    Semiconductor device
    9.
    发明授权
    Semiconductor device 失效
    半导体器件

    公开(公告)号：US06888254B2

    公开(公告)日：2005-05-03

    申请号：US09966440

    申请日：2001-09-27

    申请人： Akira Yamaguchi ,  Muneaki Maeno

    发明人： Akira Yamaguchi ,  Muneaki Maeno

    IPC分类号： H01L21/82 ,  H01L23/522 ,  H01L23/528 ,  H01L27/02 ,  H01L27/10 ,  H01L23/04 ,  H01L23/053 ,  H01L23/12 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40 ,  H01L29/73

    CPC分类号： H01L27/0207 ,  H01L23/522 ,  H01L23/5286 ,  H01L2924/0002 ,  H01L2924/00

    摘要： First and second IP cores are formed on one chip. Each of the first and second IP cores has metal layers. In the first IP core, an uppermost layer of the metal layers is thick and is a layer on which a core power source line is formed. In the second IP core, a metal layers equal in level to the uppermost layer in the first IP core becomes an intermediate layer. In the second IP core, thin intermediate layers are formed on this intermediate layer. Thin intermediate layers are layers on which signal lines are formed and have a narrow wiring pitch. In the second IP core, a layer on which a power source line is formed is provided on the thin intermediate layers.

    摘要翻译： 第一和第二IP内核形成在一个芯片上。 第一和第二IP核中的每个具有金属层。 在第一IP核中，金属层的最上层是厚的，并且是形成有核心电源线的层。 在第二IP核中，与第一IP核中的最上层相等的金属层变成中间层。 在第二IP核中，在该中间层上形成薄的中间层。 薄的中间层是其上形成信号线并且具有窄布线间距的层。 在第二IP核中，在薄中间层上设置有形成有电源线的层。