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    System and Method for Raman Based Chronic Exposure Detection
    82.
    发明申请
    System and Method for Raman Based Chronic Exposure Detection 审中-公开
    基于拉曼的慢性暴露检测系统和方法

    公开(公告)号：US20130003044A1

    公开(公告)日：2013-01-03

    申请号：US13541171

    申请日：2012-07-03

    Applicant: John Maier ,  Jeffrey Cohen ,  Ryan Priore

    Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

    IPC: G01J3/28 ,  G01J3/44

    CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

    Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

    Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

    SYSTEM AND METHOD FOR SUB-SURFACE FLUORESCENCE IMAGING
    83.
    发明申请
    SYSTEM AND METHOD FOR SUB-SURFACE FLUORESCENCE IMAGING 有权
    用于表面荧光成像的系统和方法

    公开(公告)号：US20120326055A1

    公开(公告)日：2012-12-27

    申请号：US13516977

    申请日：2010-12-17

    Applicant: Brian Campbell Wilson ,  Anthony Taywon Kim

    Inventor： Brian Campbell Wilson ,  Anthony Taywon Kim

    IPC: G01N21/64 ,  H01L27/146

    CPC classification number: G01N21/6458 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/415 ,  A61B5/418 ,  A61B5/445 ,  A61B2562/0242 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/4406 ,  G01N2021/6419 ,  G02B21/16 ,  G02B21/367 ,  G07D7/1205 ,  G07D7/128

    Abstract: A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.

    Abstract translation: 提供了一种用于亚表面荧光成像的系统，所述系统包括：用于可选择地在目标表面处至少两个激发波长或波长范围中的至少一个发光的激发源; 以及用于检测来自目标表面的荧光发射波长或波长范围的光检测器; 其中所述至少两个激发波长或波长范围中的至少一个激发波长或波长范围在亚表面深度处引起至少一个标记的荧光，所述至少两个激发波长或波长范围中的每一个处的发射光具有不同的光学穿透深度， 在各个不同深度引起荧光。 还提供了用于亚表面荧光成像的方法，在某些情况下通过重新构建亚表面荧光形貌来示例。

    HIGH SPEED MICROSCOPE WITH SPECTRAL RESOLUTION
    84.
    发明申请
    HIGH SPEED MICROSCOPE WITH SPECTRAL RESOLUTION 有权
    具有光谱分辨率的高速显微镜

    公开(公告)号：US20120257196A1

    公开(公告)日：2012-10-11

    申请号：US13439951

    申请日：2012-04-05

    Applicant: Valerica Raicu ,  Gabriel Biener

    Inventor： Valerica Raicu ,  Gabriel Biener

    IPC: G01J3/00

    CPC classification number: G01J3/2803 ,  G01J3/027 ,  G01J3/0294 ,  G01J3/06 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N2015/1006 ,  G02B21/002 ,  G02B21/0076 ,  G02B21/16 ,  G02B27/0927 ,  G02B27/0983

    Abstract: A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide two- to five-dimensional fluorescence images of samples, including two or three spatial dimensions, a spectral dimension (for fluorescence emission), and a temporal dimension (on a scale of less than approximately one second). Two-dimensional (spatial) images with a complete wavelength spectrum are generated from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The line scans may be formed using one or more of curved mirrors and lenses. The multiple beams may be formed using one of a grating, an array of lenses, and a beam splitter.

    Abstract translation: 使用具有光谱分辨率的双光子显微镜的高速显微镜的系统和方法。 显微镜可操作以提供样品的二维至五维荧光图像，包括两个或三个空间维度，光谱维度（用于荧光发射）和时间维度（小于约一秒的刻度）。 从样品的单次扫描产生具有完整波长谱的二维（空间）图像。 显微镜可以包括多光束点扫描显微镜，单束线扫描显微镜和多光束线扫描显微镜中的一个。 线扫描可以使用一个或多个弯曲镜和透镜来形成。 多个光束可以使用光栅，透镜阵列和分束器中的一个来形成。

    MICROBIAL DETECTION APPARATUS AND METHOD
    85.
    发明申请
    MICROBIAL DETECTION APPARATUS AND METHOD 有权
    微生物检测装置及方法

    公开(公告)号：US20120257192A1

    公开(公告)日：2012-10-11

    申请号：US13440841

    申请日：2012-04-05

    Applicant: Jianping JIANG

    Inventor： Jianping JIANG

    IPC: G01N21/53 ,  G01N21/64

    CPC classification number: G01N21/53 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/645 ,  G01N21/6486 ,  G01N2015/1006 ,  G01N2021/6463 ,  G01N2021/6469

    Abstract: A microbial detection apparatus is provided. The apparatus includes a parabolic reflector. A light source is configured to direct a beam of light toward the focal point of the parabolic reflector. A fluid flow tube passes through the focal point of the parabolic reflector, such that the light beam path and the flow tube intersect at the focal point of the parabola. The fluid flow tube is configured to contain a flow of fluid. A first detector is included for detecting fluorescence light emitted from microbes within the fluid passing through the flow tube. A second detector is included for detecting Mie scattered light from particles within the fluid passing through the flow tube.

    Abstract translation: 提供微生物检测装置。 该装置包括抛物面反射器。 光源被配置为将光束引向抛物面反射器的焦点。 流体流管穿过抛物面反射器的焦点，使得光束路径和流管在抛物线的焦点处相交。 流体流管构造成容纳流体流。 包括用于检测通过流管的流体中的微生物发出的荧光的第一检测器。 包括第二检测器，用于检测通过流管的流体内的颗粒的散射光。

    Pulse Combiner for the Various Spectral Colors of a Supercontinuum Laser Pulse
    86.
    发明申请
    Pulse Combiner for the Various Spectral Colors of a Supercontinuum Laser Pulse 有权
    脉冲组合器用于超连续谱激光脉冲的各种光谱颜色

    公开(公告)号：US20120218631A1

    公开(公告)日：2012-08-30

    申请号：US13402007

    申请日：2012-02-22

    Applicant: Arno Florian Warken ,  Hilmar Gugel

    Inventor： Arno Florian Warken ,  Hilmar Gugel

    IPC: G02B21/06

    CPC classification number: G02B21/0032 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6458 ,  G02B21/0076 ,  G02B2207/114

    Abstract: An illumination device (20) for a microscope (40) has a laser unit (24) that generates at least one broadband laser light pulse (30); light components (71, 72, 73, 74, 75, 76) of different wavelengths of said broadband laser light pulse (30) being offset in time from one another. A compensation unit (36) disposed in the path of the broadband laser light pulse (30) temporally offsets the light components (71, 72, 73, 74, 75, 76) of the broadband laser light pulse (30) in such a way that they exit the compensation unit (36) simultaneously or nearly simultaneously.

    Abstract translation: 用于显微镜（40）的照明装置（20）具有产生至少一个宽带激光脉冲（30）的激光单元（24）; 所述宽带激光脉冲（30）的不同波长的光分量（71,72,73,74,75,76）在时间上彼此抵消。 布置在宽带激光脉冲（30）的路径中的补偿单元（36）以这种方式暂时偏移宽带激光脉冲（30）的光分量（71,72,73,74,75,76） 他们同时或几乎同时离开补偿单元（36）。

    IMAGING SYSTEM
    89.
    发明申请
    IMAGING SYSTEM 审中-公开
    成像系统

    公开(公告)号：US20120133937A1

    公开(公告)日：2012-05-31

    申请号：US13319391

    申请日：2010-05-07

    Applicant: Rainer Heintzmann ,  Kai Wicker

    Inventor： Rainer Heintzmann ,  Kai Wicker

    IPC: G01J4/00

    CPC classification number: G02B21/367 ,  G01J3/02 ,  G01J3/4406 ,  G01J3/447 ,  G01J4/04 ,  G01N21/6445 ,  G01N21/6458

    Abstract: A method of obtaining, in a single exposure, imaging information from an object (16) representative of more than two distinct illumination images, the method comprising the steps of generating first electromagnetic waves (14) at least some of which having spatially modulated polarisation; illuminating the object with the first electromagnetic waves; and capturing second electromagnetic waves (18) emanating from the object.

    Abstract translation: 一种在单次曝光中获得来自代表多于两个不同照明图像的物体（16）的成像信息的方法，所述方法包括以下步骤：产生其中至少一些具有空间调制偏振的第一电磁波（14） 用第一电磁波照射物体; 以及捕获从物体发出的第二电磁波（18）。

    METHOD AND DEVICE FOR CHARACTERIZING MICROSCOPIC ELEMENTS
    90.
    发明申请
    METHOD AND DEVICE FOR CHARACTERIZING MICROSCOPIC ELEMENTS 有权
    用于表征微观元素的方法和装置

    公开(公告)号：US20120038916A2

    公开(公告)日：2012-02-16

    申请号：US12682268

    申请日：2011-04-01

    Applicant: Vincent Couderc ,  Philippe LeProux ,  Laurent LeFort ,  David Bouyge ,  Christelle Lesvigne-Buy ,  Aurelian Crunteanu Stanescu

    Inventor： Vincent Couderc ,  Philippe LeProux ,  Laurent LeFort ,  David Bouyge ,  Christelle Lesvigne-Buy ,  Aurelian Crunteanu Stanescu

    IPC: G01N21/63

    CPC classification number: G01J3/443 ,  G01J3/4406 ,  G01N21/645

    Abstract: A method and device is provided for characterizing microscopic elements. A source signal may be chopped by means of microsystems of opto-electromechanical elements (MOEMS), which gives rise to temporal modulation of the excitation signals. The method of characterizing microscopic elements involves propagating a dispersed light source signal, spatially chopping the spectrum of the source signal into at least two excitation signals having predetermined wavelengths λi, coding the excitation signals, focusing the excitation signals in order to generate a sensor signal propagated towards a measurement zone, and analyzing an interaction signal issuing from the interaction of the sensor signal with the microscopic elements situated in the measuring space. The spatial chopping of the spectrum of the source light signal is performed by a microsystem of opto-electromechanical elements (MOEMS).

    Abstract translation: 提供了表征微观元素的方法和装置。 源信号可以通过光电机械元件（MOEMS）的微系统来切割，这导致激励信号的时间调制。 表征微观元素的方法涉及传播分散的光源信号，将源信号的光谱空间斩波成具有预定波长λi的至少两个激励信号，对激发信号进行编码，聚焦激励信号以产生传播的信号 朝向测量区域，并且分析从传感器信号与位于测量空间中的微观元件的相互作用发出的相互作用信号。 源光信号的光谱的空间斩波由光机电元件（MOEMS）的微系统执行。

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