CELL MEMBRANE-DERIVED NANOVESICLES AND USE THEREOF

    公开(公告)号:US20180036240A1

    公开(公告)日:2018-02-08

    申请号:US15545398

    申请日:2015-08-24

    Abstract: The present invention relates to cell membrane-derived nanovesicles, a method of preparing the same, and a pharmaceutical composition and a diagnostic kit using the nanovesicles. The cell membrane-derived nanovesicles according to the present invention may prevent the occurrence of potential side effects because intracellular materials (e.g., genetic materials and cytosolic proteins) unnecessary for delivery of therapeutic or diagnostic substances are removed from the nanovesicles. In addition, since the nanovesicles may be targeted to the specific types of cells or tissues, therapeutic or diagnostic substances may be predominantly delivered to the targeted cells or tissues while delivery of therapeutic or diagnostic substances to untargeted sites may be inhibited. Therefore, when the cell membrane-derived nanovesicles are applied to disease treatment, the side effects of therapeutic substances such as drugs may be reduced, so that suffering and inconvenience of patients may be alleviated during the course of treating diseases, and therapeutic efficacy may be improved. In addition, the cell membrane-derived nanovesicles of the present invention, in which substances for the treatment or diagnosis of diseases are loaded, and a method of preparing the nanovesicles may be used in vitro or in vivo for therapeutic or diagnostic purposes, or for experimental use.

    Superhydrophilic surface body, fabricating method thereof, and filter for oil and water separation

    公开(公告)号:US09884775B2

    公开(公告)日:2018-02-06

    申请号:US15387467

    申请日:2016-12-21

    CPC classification number: C02F1/40 B01D17/02 B01D17/10

    Abstract: Disclosed are a superhydrophilic surface body, a fabricating method thereof, and a filter for oil and water separation, including a superhydrophilic surface. The method for fabricating a superhydrophilic surface body includes a first step of forming a polyaniline nanofiber layer on a surface of a base material, a second step of changing the polyaniline nanofiber layer into a completely oxidized pernigraniline base state, a third step of forming a self-assembled monomolecular film having a polymer polymerization initiation functional group on a surface of the polyaniline nanofiber layer, and a fourth step of forming a silica layer on a surface of the self-assembled monomolecular film. In the third step, the polyaniline nanofiber layer is reduced to a leucoemeraldine state.

    BATTERY CELL BALANCING CIRCUIT USING SINGLE INDUCTOR

    公开(公告)号:US20180019606A1

    公开(公告)日:2018-01-18

    申请号:US15649563

    申请日:2017-07-13

    CPC classification number: H02J7/0054 H02J7/0019 Y02T10/7055

    Abstract: The present invention relates to a battery cell balancing circuit for balancing battery cells of a battery pack using a single inductor.The battery cell balancing circuit includes a first access unit, a second access unit and an electrical energy transfer unit for an electrical energy path of a battery pack. The battery cell balancing circuit selectively connects a strong cell or weak cell of the battery pack to a single inductor by controlling switching operations of switches of the first and second access units and the electrical energy transfer unit, thereby performing battery cell balancing. Thus, the power efficiency of the battery pack can be improved, and the size and price thereof can be reduced.

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