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公开(公告)号:US20190079015A1
公开(公告)日:2019-03-14
申请号:US16116073
申请日:2018-08-29
发明人: YING-CHENG WANG , YUAN-HAO JIN , QUN-QING LI , SHOU-SHAN FAN
IPC分类号: G01N21/65 , G01J3/44 , C01B32/158
CPC分类号: G01N21/658 , C01B32/158 , C01B2202/36 , G01J3/4412 , G01N2021/651
摘要: The disclosure relates to a carrier for use in single molecule detection. The carrier includes a flexible substrate and a metal layer on the flexible substrate. The flexible substrate includes a base and a bulge pattern located on a surface of the base. The bulge pattern includes a number of strip-shaped bulges intersecting with each other to form a net and define a number of recesses. The metal layer is located on the bulge pattern. The carrier for use in single molecule detection has a relative higher SERS and can enhance the Raman scattering.
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公开(公告)号:US20180313743A1
公开(公告)日:2018-11-01
申请号:US15940698
申请日:2018-03-29
CPC分类号: G01N15/1434 , B01L3/502715 , B01L3/502761 , B01L2300/0645 , B01L2300/168 , G01N15/0806 , G01N15/1056 , G01N15/1436 , G01N15/147 , G01N21/0303 , G01N21/66 , G01N2015/0038 , G01N2015/0065 , G01N2015/03 , G01N2015/0846 , G01N2015/1006 , G01N2015/1452 , G01N2021/0325 , G01N2021/0346 , G01N2021/6482 , G01N2021/651
摘要: Particle detection cartridges are provided. Aspects of the particle detection cartridges according to certain embodiments include a sample input, a flow channel and a light channel, where the flow channel and light channel are coupled at a detection region such that only light from the detection region can propagate directly through the light channel to a detector. Systems including the cartridges, as well as methods for detecting particles in a sample with the subject particle detection cartridges/systems, are also described. Kits having one or more cartridges are also provided.
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公开(公告)号:US20180246031A1
公开(公告)日:2018-08-30
申请号:US15908628
申请日:2018-02-28
申请人: MarqMetrix Inc.
CPC分类号: G01N21/01 , G01N21/0303 , G01N21/05 , G01N21/65 , G01N2021/0106 , G01N2021/651 , G01N2201/068
摘要: A flow cell device including a spherical optical element is disclosed. The spherical lens can be sealed to the body of the flow cell device in a manner that provides external optical access to a fluid in an analysis region of a flow path through the flow cell device. The seal can be provided by an elastomer, a polymer, or a deformable metal. The disposition of the spherical lens to the flow path enables in situ optical analysis of the fluid. An optical analysis device can be removably connected to the flow cell device to provide the optical analysis. In some embodiments the optical analysis device is a portable Raman spectrometer. The flow cell device can provide a supplementary interrogation interface, and/or an on board sensor device(s) to enable multivariate analysis and/or advanced triggering.
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公开(公告)号:US20180143135A1
公开(公告)日:2018-05-24
申请号:US15570363
申请日:2015-07-29
发明人: Steven BARCELO , Ning GE , Kevin DOOLEY , Zhiyong LI
CPC分类号: G01N21/645 , G01N21/648 , G01N21/658 , G01N2021/6482 , G01N2021/651
摘要: In one example, an analyte detection package includes a substrate, surface-enhanced luminescence (SEL) structures extending from the substrate and a low wettability housing. The SEL structures have a first wettability for a given liquid. The low wettability housing extends from the substrate to form a chamber between the housing of the substrate about the SEL structures to receive an analyte containing solution. The housing has an inner surface adjacent the chamber, wherein the inner surface has a second wettability for the given liquid less than the first wettability.
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公开(公告)号:US20180136132A1
公开(公告)日:2018-05-17
申请号:US15378156
申请日:2016-12-14
申请人: BWT PROPERTY, INC.
发明人: Jun Zhao , Xin Jack Zhou , Sean Xiaolu Wang
CPC分类号: G01N21/65 , G01J3/0216 , G01J3/44 , G01N2021/651 , G01N2201/0636 , G01N2201/068 , G01N2201/08
摘要: This invention relates to a light delivery and collection device for measuring Raman scattering from a large area of a sample. The light delivery and collection device comprises a reflective cavity made of a material or having a surface coating with high reflectivity to the excitation light and the Raman scattered light. The reflective cavity has two apertures. The first aperture is configured to receive the excitation light which then projects onto the second aperture. The second aperture is configured to be applied close to the sample such that the reflective cavity substantially forms an enclosure covering a large area of the sample. The excitation light produces Raman scattered light from the covered area of the sample. The reflective cavity reflects any excitation light and Raman light scattered from the sample unless the excitation light and the Raman scattered light either emit from the first aperture to be measured with a spectrometer device, or are re-scattered by the sample at the second aperture. The multi-reflection of the reflective cavity greatly improves the excitation efficiency of Raman scattering from the sample and in the meantime enhances its collection efficiency. In addition, it also causes more excitation light to penetrate into a diffusely scattering sample and allows efficient collection of the Raman scattered light generated thereof, hence enabling sub-surface Raman scattering measurement.
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公开(公告)号:US20180136131A1
公开(公告)日:2018-05-17
申请号:US15349510
申请日:2016-11-11
申请人: BWT PROPERTY, INC.
发明人: Jun Zhao , Xin Jack Zhou
IPC分类号: G01N21/65
CPC分类号: G01N21/65 , G01N21/49 , G01N2021/651 , G01N2201/065 , G01N2201/08
摘要: This invention relates to a light delivery and collection device for measuring Raman scattering from a large area of a sample. The light delivery and collection device comprises a reflective cavity made of a material or having a surface coating with high reflectivity to the excitation light and the Raman scattered light. The reflective cavity has two apertures. The first aperture is configured to receive the excitation light which then projects onto the second aperture. The second aperture is configured to be applied close to the sample such that the reflective cavity substantially forms an enclosure covering a large area of the sample. The excitation light produces Raman scattered light from the covered area of the sample. The reflective cavity reflects any excitation light and Raman light scattered from the sample unless the excitation light and the Raman scattered light either emit from the first aperture to be measured with a spectrometer device, or are re-scattered by the sample at the second aperture. The multi-reflection of the reflective cavity greatly improves the excitation efficiency of Raman scattering from the sample and in the meantime enhances its collection efficiency. In addition, it also causes more excitation light to penetrate into a diffusely scattering sample and allows efficient collection of the Raman scattered light generated thereof, hence enabling sub-surface Raman scattering measurement.
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公开(公告)号:US09863884B2
公开(公告)日:2018-01-09
申请号:US14420510
申请日:2013-08-09
发明人: Katsumi Shibayama , Masashi Ito , Takafumi Yokino , Masaki Hirose , Anna Yoshida , Kazuto Ofuji , Yoshihiro Maruyama , Takashi Kasahara , Toshimitsu Kawai , Toru Hirohata , Hiroki Kamei , Hiroki Oyama
CPC分类号: G01N21/658 , B82Y40/00 , G01N21/03 , G01N2021/651
摘要: A SERS element comprises a substrate having a front face; a fine structure part formed on the front face and having a plurality of pillars; and a conductor layer formed on the fine structure part and constituting an optical function part for generating surface-enhanced Raman scattering. The conductor layer has a base part formed along the front face and a plurality of protrusions protruding from the base part at respective positions corresponding to the pillars. The base part has a thickness greater than the height of the pillars.
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公开(公告)号:US20180003639A1
公开(公告)日:2018-01-04
申请号:US15633774
申请日:2017-06-27
发明人: YUAN-HAO JIN , QUN-QING LI , SHOU-SHAN FAN
CPC分类号: G01N21/658 , G01J3/4412 , G01N2021/651
摘要: The disclosure relates to a carrier for single molecule detection. The carrier includes a substrate and a metal layer on the substrate, wherein the substrate includes a base and a patterned bulge located on a surface of the base, the patterned bulge includes a number of strip-shaped bulges intersected with each other to form a net and define a number of holes, and the metal layer is located on the patterned bulge. The carrier for single molecule detection has a relative higher SERS and can enhance the Raman scattering.
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69.
公开(公告)号:US20180001319A1
公开(公告)日:2018-01-04
申请号:US15536719
申请日:2014-12-16
申请人: Medcom Advance, S.A.
CPC分类号: B01L3/502715 , B01L3/502 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N21/658 , G01N2021/651
摘要: An analysis device and an analysis apparatus for identification of analytes in fluids applying the SERS effect which provides a safe way to perform analysis, avoiding an accidental cross-contamination without the use of disinfectant products; the analysis device comprising a casing enclosing a sample region for receiving a fluid sample, and a nanoparticle region for storing at least a nanoparticle fluid; the sample region and the nanoparticle region being in fluid communication each other through a passage; driving means in fluid communication with the passage; a mixing region in fluid communication with the passage; and the casing being adapted to allow an incident monochromatic light from an external source to strike on the mixing region, and a reflected light from the mixing region to leave the casing.
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公开(公告)号:US20170234799A1
公开(公告)日:2017-08-17
申请号:US15431604
申请日:2017-02-13
CPC分类号: G01N21/658 , B01L3/502753 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , G01N1/34 , G01N33/48 , G01N2001/4088 , G01N2021/651
摘要: There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.
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