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公开(公告)号：US20220233888A1
公开(公告)日：2022-07-28
申请号：US17722948
申请日：2022-04-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
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公开(公告)号：US20210299449A1
公开(公告)日：2021-09-30
申请号：US17342186
申请日：2021-06-08
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , Michael Ernest Marino
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation
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公开(公告)号：US10602950B2
公开(公告)日：2020-03-31
申请号：US15377696
申请日：2016-12-13
Applicant: General Electric Company , Brigham Young University
Inventor： Jeffrey M. Ashe , Kaustubh Ravindra Nagarkar , Christopher Michael Puleo , Christopher Fred Keimel , Craig Patrick Galligan , Yizhen Lin , Nancy Cecelia Stoffel , Richard Vanfleet , Robert Davis , Guohai Chen
IPC: A61B5/0478 , A61B5/1473 , A61B5/145 , A61B7/02 , A61N1/05 , A61B5/11 , A61B17/00
Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.
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公开(公告)号：US20200094079A1
公开(公告)日：2020-03-26
申请号：US16143255
申请日：2018-09-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
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Patent Agency Ranking
公开(公告)号：US20180361317A1
公开(公告)日：2018-12-20
申请号：US16012147
申请日：2018-06-19
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nicole Lea Wood , Li Zhu , Craig Patrick Galligan
Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.
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公开(公告)号：US20180001231A1
公开(公告)日：2018-01-04
申请号：US15209411
申请日：2016-07-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Craig Patrick Galligan , Gregory Andrew Grossmann , Erik Leeming Kvam , Robert Scott Duthie , Kenneth Wayne Rigby , Paul Michael Smigelski, JR. , Victoria Eugenia Cotero , Jason William Castle , John Donald Burczak , James Edward Rothman
Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.
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公开(公告)号：US20160002715A1
公开(公告)日：2016-01-07
申请号：US14321235
申请日：2014-07-01
Applicant: General Electric Company
Inventor： John Richard Nelson , Robert Scott Duthie , Christopher Michael Puleo , Patrick McCoy Spooner
IPC: C12Q1/68
CPC classification number: C12Q1/6848 , C12Q2531/119 , C12Q2531/125 , C12Q2565/518
Abstract: A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; applying an aqueous buffer to the sample application zone of the substrate to washes away one or more inhibitors present on the sample application zone; and applying an isothermal nucleic acid amplification reaction mixture to the sample application zone to amplify the target nucleic acid to form a nucleic acid amplification product. The target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight.
Abstract translation: 本文提供了一种方法，所述方法包括：将包含靶核酸的样品施加到底物的样品施用区; 将水性缓冲液施加到基材的样品施加区域以洗涤存在于样品施加区上的一种或多种抑制剂; 以及将等温核酸扩增反应混合物应用于样品施用区域以扩增靶核酸以形成核酸扩增产物。 具有第一分子量的靶核酸基本上固定在样品施用区，并且其中扩增产物具有第二分子量。
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公开(公告)号：US20140190831A1
公开(公告)日：2014-07-10
申请号：US14099922
申请日：2013-12-07
Applicant: General Electric Company
IPC: F04B19/00
CPC classification number: F04B19/006 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0605 , F16K99/0026 , F16K99/0042 , F16K99/0059 , Y10T137/0318 , Y10T436/2575
Abstract: A method of actuating a valve, comprises operatively coupling the valve with an electroosmotic pump; flowing a fluid through the electroosmotic pump; and generating a fluidic pressure of at least 0.75 PSI to actuate the valve, wherein the electroosmotic pump comprises one or more thin, porous, positive electroosmotic membranes and one or more thin porous, negative electroosmotic membranes; a plurality of electrodes comprising cathodes and anodes, and a power source; wherein each of the positive and negative electroosmotic membranes are disposed alternatively and wherein at least one of the cathodes is disposed on one side of one of the membranes and at least one of the anodes is disposed on the other side of the membrane and wherein at least one of the cathodes or anodes is disposed between a positive and a negative electroosmotic membrane.
Abstract translation: 一种致动阀门的方法包括将阀门与电渗泵可操作地连接; 使流体流过电渗泵; 并且产生至少0.75PSI的流体压力来致动所述阀，其中所述电渗泵包括一个或多个薄的，多孔的电渗透膜和一个或多个薄多孔的阴电渗膜; 包括阴极和阳极的多个电极和电源; 其中所述正电渗渗膜和所述阴电渗膜中的每一个交替设置，并且其中至少一个所述阴极设置在所述膜之一的一侧上，并且所述阳极中的至少一个设置在所述膜的另一侧上，并且其中至少 阴极或阳极之一设置在正电沉积膜和负电渗膜之间。
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公开(公告)号：US20140154736A1
公开(公告)日：2014-06-05
申请号：US13690801
申请日：2012-11-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk
CPC classification number: G01N1/30 , A01N1/0242 , A01N1/0284 , B01L3/5023 , B01L3/5088 , B01L7/00 , B01L2200/0678 , B01L2300/0825 , B01L2300/126 , B01L2300/1877 , G01N2001/4027 , Y10T436/2525
Abstract: A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
Abstract translation: 提供了一种干燥设置在基板上的生物样品的方法。 该方法包括提供包括样品加载区域和热源的基底; 激活热源产生热量; 将衬底加热至少高于65℃; 并干燥生物样品。 还提供了用于存储样品的装置，其中所述装置包括用于生物样品储存的基底; 以及产生热量以保持至少高于65℃的温度的加热组分。加热组分可以含有一种或多种试剂，其中试剂产生热量以保持至少高于65℃的温度。
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