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公开(公告)号：US20220175306A1
公开(公告)日：2022-06-09
申请号：US17437731
申请日：2020-03-12
Applicant: General Electric Company
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
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公开(公告)号：US11318330B2
公开(公告)日：2022-05-03
申请号：US16143255
申请日：2018-09-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
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公开(公告)号：US20210228912A1
公开(公告)日：2021-07-29
申请号：US16750932
申请日：2020-01-23
Applicant: General Electric Company
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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公开(公告)号：US20160357905A1
公开(公告)日：2016-12-08
申请号：US14730032
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Michael John Gerdes
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of biomarkers selected based on nucleic acid sequence data. The nucleic acid sequence data may be acquired for a homogeneous or heterogeneous set of cells present in the respective tissue sample.
Abstract translation: 公开了细胞图中感兴趣区域的识别。 在某些实施方案中，感兴趣区域的鉴定基于使用基于核酸序列数据选择的生物标志物。 核酸序列数据可以针对存在于各组织样品中的均质或异质的细胞组获得。
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公开(公告)号：US12029577B2
公开(公告)日：2024-07-09
申请号：US17437731
申请日：2020-03-12
Applicant: General Electric Company
CPC classification number: A61B5/4244 , A61B5/14532 , A61B5/4848 , A61N7/00 , G01N33/66 , G01N33/6872 , A61N2007/0026
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
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Patent Agency Ranking
公开(公告)号：US11426610B2
公开(公告)日：2022-08-30
申请号：US16399692
申请日：2019-04-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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公开(公告)号：US20210170203A1
公开(公告)日：2021-06-10
申请号：US16709717
申请日：2019-12-10
Applicant: General Electric Company
Inventor： John Frederick Graf , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , David Andrew Shoudy
IPC: A61N7/00
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
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公开(公告)号：US09607375B2
公开(公告)日：2017-03-28
申请号：US14729982
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Anup Sood , Vidya Pundalik Kamath
CPC classification number: G06F17/30259 , G06F19/00 , G06F19/321
Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.
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公开(公告)号：US11633630B2
公开(公告)日：2023-04-25
申请号：US16750932
申请日：2020-01-23
Applicant: General Electric Company
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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公开(公告)号：US10672505B2
公开(公告)日：2020-06-02
申请号：US14730032
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Michael John Gerdes
IPC: G16B45/00 , G16B25/00 , C12Q1/6841
Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of biomarkers selected based on nucleic acid sequence data. The nucleic acid sequence data may be acquired for a homogeneous or heterogeneous set of cells present in the respective tissue sample.
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