公开(公告)号：US20170106363A1

公开(公告)日：2017-04-20

申请号：US15291174

申请日：2016-10-12

Applicant: Endress+Hauser Conducta GmbH+Co. KG

Inventor： Xu Zhou ,  Justyna Homa ,  Thomas Schipolowski ,  Thilo Krätschmer

IPC: B01L3/00 ,  G01N33/18 ,  G01N1/28

CPC classification number: B01L3/502 ,  B01L2200/0605 ,  B01L2200/143 ,  G01F11/00 ,  G01N1/28 ,  G01N33/1806

Abstract: The present disclosure relates to a method for metering a liquid into a wet chemistry analytical device wherein a specified volume of individual liquids is placed in a metering unit consisting of a metering container and at least one dose measuring device. During the filling of the metering container with the respective liquid, after the activation of the dose measuring device, an additional volume of the liquid is drawn into the metering tube beyond the position of the dose measuring device, wherein during this procedure and afterwards the status of the dose measuring device is checked, and a conclusion is drawn from this regarding the presence of an air bubble-free liquid in the metering tube.

公开(公告)号：US20170095190A1

公开(公告)日：2017-04-06

申请号：US15261802

申请日：2016-09-09

Applicant: Theranos, Inc.

Inventor： Deborah Sloan ,  Channing Robertson

IPC: A61B5/15 ,  B01L3/00 ,  G01N33/49

CPC classification number: B01L3/502753 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150755 ,  A61B5/150763 ,  A61J1/05 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0631 ,  B01L2300/042 ,  B01L2300/0672 ,  B01L2300/12 ,  B01L2400/0406 ,  G01N1/4077 ,  G01N33/491 ,  G01N2001/4088

Abstract: Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.

公开(公告)号：US20170059516A1

公开(公告)日：2017-03-02

申请号：US15351253

申请日：2016-11-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Todd REARICK ,  Jeremy Jordan ,  John Nobile ,  William Mileski ,  Chun Heen Ho

IPC: G01N27/414 ,  B01L3/00

CPC classification number: G01N27/4145 ,  B01L3/502 ,  B01L3/52 ,  B01L7/00 ,  B01L2200/0605 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1894 ,  B01L2400/0487 ,  B01L2400/0622 ,  G01N27/414 ,  G01N31/20 ,  G05D23/19 ,  G05D23/1931

Abstract: An apparatus for detecting chemical reactions may be provided. The apparatus may comprise a chemical detection device. The chemical detection device may include a chemical sensor, which may be mounted on the chemical detection device. The apparatus may further comprise a valve block. The valve block may fluidly couple a plurality of reagent containers to the chemical detection device. The apparatus may further comprise a heat exchanger and a controller. The controller may control a fluid connection between the valve block and the chemical detection device. The controller may be also configured to adjust a temperature of a selected reagent from the plurality of reagent containers via the heat exchanger. The temperature of the selected reagent may be adjusted prior to the reagent entering the chemical detection device.

Abstract translation: 可以提供用于检测化学反应的装置。 该装置可以包括化学检测装置。 化学检测装置可以包括可安装在化学检测装置上的化学传感器。 该装置还可以包括阀块。 阀块可以将多个试剂容器流体耦合到化学检测装置。 该装置还可以包括热交换器和控制器。 控制器可以控制阀块和化学检测装置之间的流体连接。 控制器还可以被配置为经由热交换器从多个试剂容器调节所选择的试剂的温度。 可以在试剂进入化学检测装置之前调整所选择的试剂的温度。

公开(公告)号：US09566558B2

公开(公告)日：2017-02-14

申请号：US11662362

申请日：2005-09-09

Applicant: Jean-Louis Viovy ,  Max Chabert ,  Kevin Dorfman

Inventor： Jean-Louis Viovy ,  Max Chabert ,  Kevin Dorfman

IPC: C12M1/00 ,  C12Q1/68 ,  C02F1/40 ,  G01N15/06 ,  G01N33/48 ,  G01N27/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  F04B19/00 ,  G01N35/08 ,  B01L7/00 ,  G01N15/00 ,  G01N35/10

CPC classification number: B01L3/502784 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0097 ,  B01L3/5027 ,  B01L3/502723 ,  B01L7/525 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/1816 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0493 ,  C12Q1/686 ,  F04B19/006 ,  G01N35/08 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2035/1037

Abstract: The present invention concerns a microfluidic device (1) for performing physical, chemical or biological treatment to at least one packet without contamination.

Abstract translation: 本发明涉及用于对至少一个包进行物理，化学或生物处理而不被污染的微流体装置（1）。

公开(公告)号：US09545631B2

公开(公告)日：2017-01-17

申请号：US14483833

申请日：2014-09-11

Applicant: TECAN TRADING AG

Inventor： Marc N. Feiglin

IPC: G01N27/453 ,  B01L3/00 ,  B01L3/02 ,  G01N27/447 ,  B01F13/00 ,  B01L7/00 ,  C12Q1/68

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: Cartridge has a container with at least one well having a channel from a well opening to a container base side, protrusions on the container base side, and a flat polymer film with a hydrophobic upper surface kept at a distance from the base side by the protrusions. The container and film are reversibly attachable to a liquid droplet manipulation instrument so the lower surface of the film abuts at least one electrode array of the instrument. The container enables displacement of a liquid droplet from a well through the channel onto the hydrophobic upper surface and above the electrode array. The instrument has a control unit with a voltage control and an electrode selector for individually selecting each electrode of the electrode array and for providing the selected electrode with a voltage to controlling guided movement of a liquid droplet by electrowetting. A kit and method are also disclosed.

Abstract translation: 墨盒具有容器，该容器具有至少一个孔，该孔具有从孔口到容器基底侧的通道，容器基底侧上的突起，以及具有疏水性上表面的平坦聚合物膜，该疏水性上表面通过突起 。 容器和膜可逆地附接到液滴操作仪器，使得膜的下表面邻接仪器的至少一个电极阵列。 容器使得液体液滴从阱通过通道移动到疏水性上表面和电极阵列上方。 仪器具有带电压控制的控制单元和电极选择器，用于单独选择电极阵列的每个电极，并为所选择的电极提供电压，以通过电润湿来控制液滴的引导运动。 还公开了试剂盒和方法。

公开(公告)号：US20160362677A1

公开(公告)日：2016-12-15

申请号：US15249771

申请日：2016-08-29

Applicant: NeuMoDx Molecular, Inc.

Inventor： Jeffrey Williams ,  Sundaresh Bramasandra ,  Michael T. Kusner

IPC: C12N15/10 ,  B01L9/00 ,  B01L3/00 ,  C12Q1/68 ,  B01L7/00

CPC classification number: C12N15/1013 ,  B01L3/502 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/508 ,  B01L3/527 ,  B01L3/567 ,  B01L7/52 ,  B01L7/525 ,  B01L9/00 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0615 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/065 ,  B01L2400/0655 ,  B01L2400/0694 ,  B01L2400/086 ,  B29C65/08 ,  B29C65/484 ,  B29C65/606 ,  B29C66/71 ,  B29C66/81423 ,  B29C66/8322 ,  B29L2031/756 ,  C12M23/42 ,  C12N13/00 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6813 ,  C12Q1/686 ,  B29K2021/00

Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

公开(公告)号：US20160349090A1

公开(公告)日：2016-12-01

申请号：US15159221

申请日：2016-05-19

Applicant: Stichting IMEC Nederland

Inventor： Marcel Arie Günther Zevenbergen ,  Rajesh Mandamparambil ,  Chuan Nie ,  Arnoldus Joannes Hubertus Frijns ,  Jacob Marinus Jan Den Toonder

IPC: G01F1/56 ,  G01F1/34

CPC classification number: G01F1/00 ,  B01L3/5027 ,  B01L3/502723 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0678 ,  B01L2300/048 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0487 ,  G01F1/68

Abstract: The present disclosure relates to an arrangement for providing information about a flow rate of a fluid, comprising: a fluid inlet opening, at least one flow channel, and at least one porous zone located above the at least one flow channel, wherein the surface size and position of the at least one porous zone relative to the fluid inlet opening defines the evaporation rate of a fluid, arranged such that when a fluid is injected through the fluid inlet opening the fluid flows via hydraulic pressure through the at least one flow channel and then through the respective at least one porous zone.

Abstract translation: 本发明涉及一种用于提供关于流体流速的信息的装置100，包括：流体入口开口111，至少一个流动通道112和位于流动通道上方的至少一个多孔区域114，其中表面 至少一个多孔区域114相对于流体入口开口111的尺寸和位置限定了流体的蒸发速率，其布置成使得当流体通过流体入口开口111注入时，流体经由液压通过至少一个 流动通道112，然后通过相应的至少一个多孔区域114

公开(公告)号：US09493826B2

公开(公告)日：2016-11-15

申请号：US14177190

申请日：2014-02-10

Applicant: California Institute of Technology ,  University of Chicago

Inventor： Rustem F. Ismagilov ,  Feng Shen ,  Jason E. Kreutz ,  Wenbin Du ,  Bing Sun

IPC: C12Q1/68 ,  B01F13/00 ,  B01L3/00

CPC classification number: C12Q1/6851 ,  B01F5/0085 ,  B01F13/0094 ,  B01F15/0218 ,  B01L3/5025 ,  B01L3/502738 ,  B01L3/50851 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0644 ,  B01L2400/065 ,  C12Q2531/119 ,  C12Q2537/149 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.

Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。

公开(公告)号：US20160318019A1

公开(公告)日：2016-11-03

申请号：US15206669

申请日：2016-07-11

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David J. Ledden ,  Dafeng Chen ,  James E. Rasmussen

IPC: B01L3/00 ,  G01N1/30

CPC classification number: B01L3/502753 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/14 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0688 ,  B01L2400/084 ,  G01N1/30

Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.

公开(公告)号：US20160303564A1

公开(公告)日：2016-10-20

申请号：US14689508

申请日：2015-04-17

Applicant: CYTONOME/ST, LLC

Inventor： John R. Gilbert ,  Sebastian Böhm ,  Manish Deshpande

IPC: B01L3/00 ,  F16K99/00

CPC classification number: B01L3/502746 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2400/06 ,  B01L2400/082 ,  F16K99/0019 ,  F16K99/0061 ,  F16K2099/0084

Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

Abstract translation: 微流体系统包括用于调节通过微通道的流体流动的气泡阀。 气泡阀包括与微通道内部接合的流体弯液面和用于将膜偏转到微通道内部以调节流体流动的致动器。 当在膜上产生足够的压力时，致动器在微通道中的液体中产生气泡。