公开(公告)号：US09827566B2

公开(公告)日：2017-11-28

申请号：US15157428

申请日：2016-05-18

Applicant: IDEA MACHINE DEVELOPMENT DESIGN AND PRODUCTION LTD

Inventor： Shlomo Turgeman ,  Ben Zion Lavi ,  Eitan Sheffer

IPC: B01L3/00 ,  G01N31/16 ,  A61J1/06 ,  G01F22/00 ,  G01G17/04

CPC classification number: B01L3/5085 ,  B01L3/50851 ,  B01L3/50855 ,  B01L2200/025 ,  B01L2200/147 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1811 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01F22/00 ,  G01G17/04

Abstract: There is provided plate equipped with a mechanism to facilitate determination of the amount of a fluid added to or removed from a well in the plate. Other embodiments are also described.

公开(公告)号：US20170333895A1

公开(公告)日：2017-11-23

申请号：US15519981

申请日：2015-10-22

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： James J. Collins ,  Keith Pardee

IPC: B01L3/00 ,  G01N21/64 ,  G01N21/27 ,  G01N21/03 ,  G01N21/25

CPC classification number: B01L3/5085 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/161 ,  B01L2300/168 ,  G01N21/03 ,  G01N21/253 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6452

Abstract: Disclosed herein are multiwell plates suitable for spectrophotometry for low-volume liquid samples. For the multiwell plates, the bottom of at least one well has a layer of porous matrix disposed thereon, or is comprised of a layer of porous matrix. The layer of porous matrix permits a low-volume liquid sample to distribute evenly across the porous matrix. Also disclosed herein are methods of performing a photometric or spectrophotometric measurement on a liquid sample having a small volume, by using a multiwell plate comprising a layer of porous matrix.

公开(公告)号：US20170328862A1

公开(公告)日：2017-11-16

申请号：US15607403

申请日：2017-05-26

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Thomas JACKSON

IPC: G01N27/447 ,  F16B2/18 ,  B01L3/00

CPC classification number: G01N27/44739 ,  B01L3/502 ,  B01L3/563 ,  B01L3/565 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/06 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2400/0421 ,  B33Y80/00 ,  C07H1/06 ,  C07K1/26 ,  F16B2/18 ,  G01N27/44704 ,  Y10T29/49117 ,  Y10T403/7009

Abstract: An expanding cam lock for use with an electrophoresis system is disclosed herein. The cam lock allows the simultaneous use of multiple slab gel cassettes in first and second buffer core assemblies in an electrophoresis system while maintaining the necessary compressive force to create a liquid-tight seal between the anode and cathode buffer solutions. In one example embodiment, the expanding cam lock includes a base plate with a first surface adapted to engage the first buffer core assembly and a follower plate having second surface adapted to engage the second buffer core assembly, buffer dam or buffer displacement dam. The base plate and the follower plate are slidably coupled together and are designed for insertion between the first buffer core assembly and the second buffer core assembly, buffer dam or buffer displacement dam in the electrophoresis container. A cam is positioned between and moveably coupled with the base plate and the follower plate. The cam is movable from a first position to a second position to urge the first and second surfaces to secure the gel cassette to the first and second buffer core assemblies. Also provided herein is a buffer displacement dam. Also provided herein are kits and assemblies which incorporate the expanding cam and buffer displacement dam described herein.

公开(公告)号：US09817011B2

公开(公告)日：2017-11-14

申请号：US15430726

申请日：2017-02-13

Applicant: GEN-PROBE INCORPORATED

Inventor： David Buse ,  Byron J. Knight

IPC: G01N35/10 ,  G01N35/02 ,  G01N35/00 ,  B65D1/36 ,  B65D17/50 ,  B01L3/00

CPC classification number: B01L3/5085 ,  B01L3/502 ,  B01L3/5082 ,  B01L3/50825 ,  B01L3/50853 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/02 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0609 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/12 ,  B01L2400/0406 ,  B65B69/00 ,  B65D1/0207 ,  B65D1/34 ,  B65D1/36 ,  B65D17/50 ,  B65D39/0017 ,  B65D39/0029 ,  B65D2539/003 ,  C12Q1/686 ,  G01N30/6091 ,  G01N35/0099 ,  G01N35/026 ,  G01N35/10 ,  G01N35/1002 ,  G01N35/1079 ,  G01N2035/00287 ,  Y10T436/11

Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.

公开(公告)号：US20170283855A1

公开(公告)日：2017-10-05

申请号：US15363896

申请日：2016-11-29

Applicant: Combinati, Inc.

Inventor： Ju-Sung HUNG ,  Andrew ZAYAC ,  Megan DUECK

IPC: C12Q1/68 ,  B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/12 ,  B01L2400/0487 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: A microfluidic device can have a plurality of microchambers connected to a microchannel via siphon apertures. The microfluidic device may be formed from a thermoplastic and capped by a thermoplastic thin film. The microfluidic device may be used for digital polymerase chain reactions by forcing reagent into the microchambers at low pressure via an inlet, forcing any gas trapped in the microfluidic device to outgas through the thin film by applying high pressure to the microfluidic device via inlets and outlets of the microfluidic device, and applying air at low pressure to the inlets in order to digitize the chambers such that the reagent in each chamber is isolated from the reagent in other chambers by an air gap. After digitization, the device may be used to run a digital polymerase chain reaction process.

公开(公告)号：US20170274374A1

公开(公告)日：2017-09-28

申请号：US15471730

申请日：2017-03-28

Applicant: Ilumina, Inc.

Inventor： M. Shane Bowen ,  Michael Graige ,  Stanley S. Hong ,  John A. Moon ,  Merek Siu

IPC: B01L3/00 ,  C12Q1/68

CPC classification number: B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00509 ,  B01J2219/00621 ,  B01J2219/00662 ,  B01J2219/00668 ,  B01J2219/00722 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0848 ,  B01L2300/0851 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6874 ,  C12Q2565/537

Abstract: An array including a solid support having a plurality of contours along its exterior surface. A first subset of contours is positioned along the exterior surface of the solid support to form a first pattern of features and a second subset of contours is positioned along the exterior surface to form a second pattern of features. The contours of the first subset are juxtaposed with the second subset along the exterior surface, whereby the first and second patterns form an interleaved pattern. The features of the first pattern occur at a first elevation z1 and the features of the second pattern occur at a second elevation z2. The features of the first pattern are configured to attach analytes at a different elevation relative to analytes attached to the features of the second pattern.

公开(公告)号：US09764079B2

公开(公告)日：2017-09-19

申请号：US14391914

申请日：2013-04-12

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Amin I. Kassis

IPC: B04B5/04 ,  A61M1/36 ,  B01L3/00 ,  A61J1/20

CPC classification number: A61M1/3693 ,  A61J1/2037 ,  A61J1/2051 ,  A61J1/2096 ,  B01L3/5021 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2400/0644 ,  B04B5/0414

Abstract: Kits and methods provide for the isolation of white blood cells from bodily fluids. In one exemplary aspect, a method for isolating white blood cells from blood includes the act of adding a blood sample to a separation tube having a distal end, a proximal end, and a valve located proximate said proximal end, said valve being configured to transition between at least first, second, and third positions. The method also includes the act of removably attaching a cap to the distal end, centrifuging the separation tube with the valve in the first position, removing the cap at the distal end of the separation tube and removably attaching a first syringe to the proximal end, switching the valve to the second position and withdrawing, via the first syringe, a red blood cell sediment. The method also includes the act of switching the valve to the first position and removing the first syringe, adding a small volume of buffer to the separation tube, removably attaching a cap to the distal end and centrifuging the separation tube and removing the cap at the distal end of the separation tube and removably attaching a second syringe to the proximal end. Additional acts include switching the valve to the second position, withdrawing the remaining red blood cell sediment via the second syringe and switching the valve to the first position and removing the second syringe.

公开(公告)号：US09759663B2

公开(公告)日：2017-09-12

申请号：US14877411

申请日：2015-10-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, Jr. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/64 ,  G01N21/75 ,  B01L3/00 ,  B29C59/04 ,  G01N21/03 ,  G01N21/25 ,  G01N21/31 ,  G01N21/55 ,  B29C35/08 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C59/02

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

公开(公告)号：US20170160230A1

公开(公告)日：2017-06-08

申请号：US15430312

申请日：2017-02-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Thomas JACKSON

IPC: G01N27/447 ,  F16B2/18 ,  B01L3/00 ,  C07K1/26 ,  C07H1/06

CPC classification number: G01N27/44739 ,  B01L3/502 ,  B01L3/563 ,  B01L3/565 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/06 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2400/0421 ,  B33Y80/00 ,  C07H1/06 ,  C07K1/26 ,  F16B2/18 ,  G01N27/44704 ,  Y10T29/49117 ,  Y10T403/7009

Abstract: An expanding cam lock for use with an electrophoresis system is disclosed herein. The cam lock allows the simultaneous use of multiple slab gel cassettes in first and second buffer core assemblies in an electrophoresis system while maintaining the necessary compressive force to create a liquid-tight seal between the anode and cathode buffer solutions. In one example embodiment, the expanding earn lock includes a base plate with a first surface adapted to engage the first buffer core assembly and a follower plate having second surface adapted to engage the second buffer core assembly, buffer dam or buffer displacement dam. The base plate and the follower plate are slidably coupled together and are designed for insertion between the first buffer core assembly and the second buffer core assembly, buffer dam or buffer displacement dam in the electrophoresis container. A cam is positioned between and moveably coupled with the base plate and the follower plate. The cam is movable from a first position to a second position to urge the first and second surfaces to secure the gel cassette to the first and second buffer core assemblies. Also provided herein is a buffer displacement dam. Also provided herein are kits and assemblies which incorporate the expanding cam and buffer displacement dam described herein.

公开(公告)号：US09637733B2

公开(公告)日：2017-05-02

申请号：US13917462

申请日：2013-06-13

Applicant: Samsung Electronics Co., Ltd.

Inventor： Chin-sung Park ,  Kak Namkoong ,  Joon-sub Shim ,  Won-seok Chung ,  Kyung-ho Kim ,  Joon-ho Kim ,  Won-jong Jung

IPC: C12N15/10 ,  B01L3/00

CPC classification number: C12N15/1017 ,  B01L3/527 ,  B01L2300/0851 ,  B01L2300/0861

Abstract: A reagent supply device includes a plurality of chambers which are separated from each other such that different reagents may be injected, the plurality of chambers having bottom surfaces made of a membrane, the membrane comprising a destruction pattern which is formed at a position corresponding to each of the plurality of chambers and breachable by an external impact to discharge the injected reagent from the chamber.