公开(公告)号：US20240255505A1

公开(公告)日：2024-08-01

申请号：US18290089

申请日：2022-06-16

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Jiro HIROTA ,  Satoru UNO ,  Yasushi OCHIAI ,  Shizuka ITO ,  Keisuke WATANABE ,  Shinya OKUYAMA ,  Tomohide ASAI

IPC: G01N33/569 ,  C07K14/005 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/1002 ,  C07K2317/565 ,  C12N2770/20022 ,  G01N2333/165

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2 in a biological sample, including using two types of monoclonal antibodies or antibody fragments thereof that bind to a peptide fragment having 30 or less consecutive amino acids in a nucleocapsid protein of SARS-CoV-2, wherein the two types of monoclonal antibodies or antibody fragments thereof recognize different epitopes

公开(公告)号：US20240077504A1

公开(公告)日：2024-03-07

申请号：US18548614

申请日：2022-03-04

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Toshiki KAWABE ,  Yukio ODA

IPC: G01N33/86

CPC classification number: G01N33/86

Abstract: A method for estimating a cause of coagulation time prolongation includes 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen having a prolonged coagulation time; 2) calculating T(X), wherein T(X) represents a measurement point or time at which the coagulation reaction curve reaches X % of Pe, and X is a variable of greater than 0 and equal to or less than 100; and 3) estimating a cause of coagulation time prolongation of the subject blood specimen based on a form of T(X).

公开(公告)号：US11867694B2

公开(公告)日：2024-01-09

申请号：US16616371

申请日：2018-05-24

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Satoru Sugimoto ,  Takeshi Wakiya ,  Shinichiro Kitahara ,  Maasa Yaji ,  Yuya Inaba

IPC: G01N33/546 ,  C08F12/32 ,  C08F12/08 ,  C08F22/20 ,  C08F28/06

CPC classification number: G01N33/546 ,  C08F12/08 ,  C08F12/32 ,  C08F22/20 ,  C08F28/06

Abstract: The present invention relates to latex particles for measurement reagents, said latex particles having a coefficient of variation in particle diameters of 10% or less and an average particle diameter of 250 to 1000 nm. Each of the latex particles contains 20% by weight or more of a compound having a refractive index of 1.60 or more. The depth of a supernatant is 5 mm or less when a liquid dispersion having a solid matter concentration of 1% by weight, which is prepared by dispersing the latex particles in ultrapure water, is placed in a tubular 10-ml measuring cylinder having a body inner diameter of 10.8 mm and is then allowed to leave for 10 days. According to the particles, a measurement of a measurement sample can be performed at a high sensitivity even when the concentration of a substance to be tested in the measurement sample is low.

公开(公告)号：US20230333070A1

公开(公告)日：2023-10-19

申请号：US18026659

申请日：2021-09-14

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Shoutarou KOBARU ,  Takamasa KOUNO ,  Nobuhiko INUI ,  Kazuhiko IMAMURA ,  Sou YAMAGUCHI ,  Katsura UCHIDA ,  Tatsunori TAKAMATSU

IPC: G01N35/08 ,  G01N30/26

CPC classification number: G01N30/26 ,  G01N35/08

Abstract: Provided is an inspection chip with simplified channel switching structure, which is generally complicated. An inspection chip 1 including a chip main body 2 having a specimen introduction channel, an adsorption channel including an adsorption unit, a first waste liquid channel, a recovery liquid introduction channel, and a detection channel including a detection unit; and a rotary valve 3 attached to the chip main body 2 so as to be rotatable about a rotation axis, the rotary valve 3 having a plurality of connection channels, the plurality of connection channels being arranged so that the rotary valve 3 is capable of taking at least a first state and a second state when the rotary valve 3 rotates about the rotation axis, the first state being a state in which the specimen introduction channel, the adsorption channel, and the first waste liquid channel are connected so as to be provided in this order from an upstream side, and the second state being a state in which the recovery liquid introduction channel, the adsorption channel, and the detection channel are connected so as to be provided in this order from the upstream side.

公开(公告)号：US11719689B2

公开(公告)日：2023-08-08

申请号：US16639091

申请日：2018-12-25

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Ryusuke Okamoto ,  Kuniya Komai

IPC: G01N33/49 ,  A61J1/14 ,  B01D21/26 ,  G01N1/28

CPC classification number: G01N33/491 ,  A61J1/1468 ,  B01D21/262 ,  G01N1/28 ,  B01D2221/10

Abstract: There is provided a composition for separating blood serum or blood plasma that can inhibit bubbling during sterilization, and can inhibit the occurrence of phase separation during storage. The composition for separating blood serum or blood plasma according to the present invention comprises a (meth)acrylic acid ester-based polymer, a silica fine powder, and a silicone oil, wherein the (meth)acrylic acid ester-based polymer has fluidity at room temperature, and has a weight average molecular weight of 15000 or more and 100000 or less.

公开(公告)号：US11702688B2

公开(公告)日：2023-07-18

申请号：US16086144

申请日：2017-03-29

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Hiroyuki Ebinuma ,  Katsura Uchida ,  Yuriko Tsukamoto

IPC: C12Q1/68 ,  C12Q1/6858 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6876

CPC classification number: C12Q1/6858 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y207/07007

Abstract: An object of the present invention is to provide a novel method for designing a primer ensuring reactivity and discriminatory power in a method for detecting a single base substitution based on an ASP-PCR method and to provide a method for easily detecting multiple point mutations within overlapping amplicons, particularly, two adjacent single base substitutions. The single base substitutions can easily be detected by using a mutant primer in which the base of the third nucleotide from the 3′ end corresponds to the base of a mutant nucleotide of a single base substitution contained in a nucleic acid sample, in which the base of the second nucleotide from the 3′ end is not complementary to the base of the corresponding nucleotide of the nucleic acid, and in which the bases of the other nucleotides are complementary to the bases of the corresponding nucleotides of the nucleic acid.

公开(公告)号：US20230213497A1

公开(公告)日：2023-07-06

申请号：US17995682

申请日：2021-04-07

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Toshiki KAWABE

IPC: G01N33/49

CPC classification number: G01N33/4905

Abstract: Provided is a method for accurately measuring coagulation time of blood specimens showing various coagulation reactions. The method for measuring blood coagulation time includes acquiring coagulation reaction P(i) of a subject specimen and reaction velocity V(i); calculating a calculation start point Te by using the ratio of the V(i) to maximum reaction velocity as an index; and calculating time Tc giving P(Tc)=P(Te)×N % (0

公开(公告)号：US20230158505A1

公开(公告)日：2023-05-25

申请号：US17912216

申请日：2021-03-23

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD.

Inventor： Takaya UCHIYAMA ,  Kuniya KOMAI ,  Masatoshi NIUNOYA ,  Yuuki GOTOU ,  Hironobu ISOGAWA

IPC: B01L3/00 ,  A61B5/15 ,  G01N1/38

CPC classification number: B01L3/5082 ,  A61B5/15 ,  G01N1/38 ,  A61B10/0096

Abstract: A specimen collection container is provided, the specimen collection container being capable of suppressing a change in a mixing ratio of a specimen collected to a liquid contained even when a long period of time has elapsed after manufacturing. A specimen collection container according to the present invention is a specimen collection container into which a specimen is collected, the specimen collection container including: a container main body having an opening; a plug attached to the opening; a barrier film disposed on an outer surface of the container main body; and a liquid contained in the container main body, the barrier film having a water vapor transmission rate at 40° C. and 90% RH of 0.8 g/(m2·day) or less.

公开(公告)号：US11542287B2

公开(公告)日：2023-01-03

申请号：US17105855

申请日：2020-11-27

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Shinya Yano ,  Kenta Saito ,  Hideki Kubota

IPC: C07F7/18 ,  C07B63/04 ,  C07C43/23 ,  C07C211/27 ,  C07C265/08

Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.
An alkyldiphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group), isocyanate group, an azide group, or a halogen atom, Z represents a C1-4 linear or branched alkyl group, an alkenyl group, or a cycloalkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—R11—X-A  (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom or a C1-4 alkyl group); and A represents, for example, a group represented by formula (3): wherein R12, R13, and R14 may be the same or different and each independently represent a C1-6 linear or branched alkyl group or an optionally substituted aryl group; R15 represents a single bond or a C1-3 linear or branched alkylene group; and R16, R17, and R18 each independently represent a C1-3 linear or branched alkylene group.

公开(公告)号：US20220349911A1

公开(公告)日：2022-11-03

申请号：US17811070

申请日：2022-07-07

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Toshiki KAWABE ,  Tomohisa NISHIO ,  Hirotoshi MATSUSHITA ,  Shota TAKIMORI ,  Toyomi YAMAGUCHI

IPC: G01N35/10 ,  G01N35/02

Abstract: An automatic analysis apparatus is capable of stirring a reagent without reducing the analysis processing capacity. The automatic analysis apparatus includes a reagent table that is rotatable and that holds reagent vessels, and a plurality of magnets are disposed below the reagent table, with orientations of magnetic poles of the magnets fixed, along a movement path of the reagent vessels moving on a circumference when the reagent table is rotationally driven. The plurality of magnets is disposed such that the fixed orientations of the magnetic poles of the magnets vary along the movement path, and act a magnetic force on a stirring bar in each of the reagent vessels. When the reagent table is rotated and the reagent vessels pass above the magnets, the stirring bar in each of the reagent vessels is rotated or oscillated by the magnetic force received from the magnets, to stir the reagent.