公开(公告)号：US20230158505A1

公开(公告)日：2023-05-25

申请号：US17912216

申请日：2021-03-23

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD.

Inventor： Takaya UCHIYAMA ,  Kuniya KOMAI ,  Masatoshi NIUNOYA ,  Yuuki GOTOU ,  Hironobu ISOGAWA

IPC: B01L3/00 ,  A61B5/15 ,  G01N1/38

CPC classification number: B01L3/5082 ,  A61B5/15 ,  G01N1/38 ,  A61B10/0096

Abstract: A specimen collection container is provided, the specimen collection container being capable of suppressing a change in a mixing ratio of a specimen collected to a liquid contained even when a long period of time has elapsed after manufacturing. A specimen collection container according to the present invention is a specimen collection container into which a specimen is collected, the specimen collection container including: a container main body having an opening; a plug attached to the opening; a barrier film disposed on an outer surface of the container main body; and a liquid contained in the container main body, the barrier film having a water vapor transmission rate at 40° C. and 90% RH of 0.8 g/(m2·day) or less.

公开(公告)号：US20230090675A1

公开(公告)日：2023-03-23

申请号：US17908407

申请日：2021-03-11

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD.

Inventor： Kuniya KOMAI ,  Hironobu ISOGAWA

IPC: B01L3/00 ,  G01N33/487

Abstract: Provided is a blood collection container with which a specimen with a high leukocyte recovery rate and a small amount of contaminating erythrocytes can be obtained. A blood collection container according to the present invention is a blood collection container by which a predetermined amount of blood is collected, the blood collection container including: a blood collection container main body; and a hemocyte separation material contained in the blood collection container main body, the hemocyte separation material having a specific gravity at 25° C. of 1.075 or more and 1.093 or less, and the blood collection container including: a configuration of including a hemagglutinating agent contained in the blood collection container main body (configuration A2); or a configuration of including an osmotic pressure regulator contained in the blood collection container main body, and when a water-soluble component contained in the blood collection container main body is dissolved with physiological saline in an amount equal to a predetermined amount of blood to be collected in the blood collection container to obtain a solution for osmotic pressure measurement, the solution for osmotic pressure measurement having an osmotic pressure of 300 mOsm/L or more and 500 mOsm/L or less (configuration B2).

公开(公告)号：US20230133626A1

公开(公告)日：2023-05-04

申请号：US17907866

申请日：2021-03-03

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD.

Inventor： Yuuki GOTOU ,  Hironobu ISOGAWA ,  Takaya UCHIYAMA ,  Tomonori INOUE

IPC: A01N1/02

Abstract: Provided is a storage container for cell-containing solutions, which makes it possible to enhance the storage stability of cfDNA contained in a cell-containing solution even when the cell-containing solution is stored under a room temperature environment. The storage container for cell-containing solutions according to the present invention is intended to be used for storing a predetermined amount of a cell-containing solution, the storage container being provided with a container main body and a preservative solution contained in the container main body, in which the storage container has a first configuration such that the preservative solution contains a cell-membrane-permeable compound that has a molecular weight of 100 or less and cannot be frozen at 0° C. and, when a mixed solution X is prepared by collecting the predetermined amount of the cell-containing solution in the storage container for cell-containing solutions and mixing the cell-containing solution with the preservative solution, the content of the cell-membrane-permeable compound in the mixed solution X is 1 vol % to 5vol % inclusive, or the storage container has a second configuration such that the preservative solution contains a cell-membrane-impermeable compound having a molecular weight of 300 or more and, when a mixed solution X is prepared by collecting the predetermined amount of the cell-containing solution in the storage container for cell-containing solutions and mixing the cell-containing solution with the preservative solution, the content of the cell-membrane-impermeable compound in the mixed solution X is 0.5 μmol/L to 5 μmol/L inclusive.

公开(公告)号：US20230050815A1

公开(公告)日：2023-02-16

申请号：US17783156

申请日：2020-11-30

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD.

Inventor： Yuji SETOGUCHI ,  Hironobu ISOGAWA

IPC: A61B5/15 ,  A61J1/05 ,  A61M1/36

Abstract: Provide is a blood collection container capable of suppressing the occurrence of blood clots involving bubbles when blood containing heparin is coagulated, and capable of suppressing the production of fibrin in serum after separation when blood containing heparin is separated into serum and blood clots. A blood collection container according to the present invention includes: a blood collection container main body having an opening at one end thereof and a closed bottom at the other end thereof; a serine protease disposed in the blood collection container main body; and a heparin neutralizing agent disposed in the blood collection container main body, wherein when a region in which the serine protease is disposed is defined as a first region, and a region in which the heparin neutralizing agent is disposed is defined as a second region, the second region includes a region present on an other end side with respect to an end on the other end side of the first region.

公开(公告)号：US20220226752A1

公开(公告)日：2022-07-21

申请号：US17608281

申请日：2020-05-19

Applicant: SEKISUI MEDICAL CO., LTD. ,  TOKUYAMA SEKISUI CO., LTD

Inventor： Kuniya KOMAI ,  Hironobu ISOGAWA ,  Hideo ANRAKU

IPC: B01D17/02 ,  G01N33/49 ,  G01N33/50 ,  A61J1/05 ,  B01D21/26 ,  B01L3/00

Abstract: Provided is a composition for mononuclear cell-containing plasma separation capable of suppressing a flow of the composition for mononuclear cell-containing plasma separation during storage, capable of satisfactorily forming a partition during centrifugation, and capable of yielding mononuclear cell-containing plasma with little admixture of blood cell components other than mononuclear cells. The composition for mononuclear cell-containing plasma separation according to the present invention contains an organic component having fluidity at 25° C. and two or more kinds of inorganic fine powders, and has a specific gravity of 1.060 or more and 1.080 or less at 25° C.