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108 条记录 (耗时 0.02 秒)

    Process for the preparation of 4-amino-diphenylamines
    31.
    发明授权
    Process for the preparation of 4-amino-diphenylamines 失效
    制备4-氨基 - 二苯胺的方法

    公开(公告)号：US4326080A

    公开(公告)日：1982-04-20

    申请号：US158540

    申请日：1980-06-11

    申请人： Karlfried Wedemeyer ,  Siegfried Bohm

    发明人： Karlfried Wedemeyer ,  Siegfried Bohm

    IPC分类号： C07B61/00 ,  B01J21/00 ,  B01J29/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/18 ,  C07C209/22 ,  C07C211/53 ,  C07C85/02 ,  C07C85/06

    CPC分类号： C07C209/18

    摘要： A process for the preparation of a 4-aminodiphenyl amino derivative which comprises:(a) contacting a hydroxybenzene of the formula ##STR1## wherein R is hydroxyl or amino with an aniline compound of the formula ##STR2## wherein R.sub.1 represents hydrogen or an alkyl radical in the presence of a .gamma.-aluminum oxide containing catalyst; and(b) contacting the product from step (a) with ammonia in the presence of the same .gamma.-aluminum oxide containing catalyst used in step (a).

    摘要翻译： 一种制备4-氨基二苯基氨基衍生物的方法，其包括：（a）使式IMA图的羟基苯与式Ia的苯胺化合物接触，其中R是羟基或氨基，其中R1代表氢或烷基 在含有γ-氧化铝的催化剂的存在下自由基; 和（b）在步骤（a）中使用的相同的含γ-氧化铝的催化剂的存在下，使来自步骤（a）的产物与氨接触。

    Process for preparing methylene dianilines
    32.
    发明授权
    Process for preparing methylene dianilines 失效
    制备亚甲基二苯胺的方法

    公开(公告)号：US4294987A

    公开(公告)日：1981-10-13

    申请号：US108522

    申请日：1979-12-31

    申请人： Richard A. Prather ,  Nirad N. Shah

    发明人： Richard A. Prather ,  Nirad N. Shah

    IPC分类号： C07C211/53 ,  C07C67/00 ,  C07C209/00 ,  C07C209/54 ,  C07C209/60 ,  C07C209/78 ,  C07C211/50 ,  C08G20060101 ,  C07C85/145

    CPC分类号： C07C209/78 ,  Y02P20/582

    摘要： An improvement is described in the process of preparing polymethylene polyphenyl polyamines by condensing aniline and formaldehyde in the presence of an acid catalyst in the initial condensation. The improvement enables the amount of acid which has to be neutralized at the end of the reaction to be substantially reduced or eliminated entirely. This is accomplished without sacrifice of the high level of 4,4'-isomer of di(aminophenyl)methane normally present in the diamine content of the polyamines when a mineral acid catalyst is employed in the condensation. The improvement comprises conducting the initial condensation of aniline and formaldehyde in the presence of a strong acid at a level normally employed to obtain high 4,4'-isomer content in the diamine component of the polyamine product, subjecting the reaction mixture, at the stage at which benzylamine formation is substantially complete, to solvent extraction after adjusting the aniline and water content of the reaction mixture to specified levels, recovering the mixture of benzylamine and excess aniline from the solvent extract and subjecting this mixture (optionally after removal of aniline) to rearrangement to the desired polyamine product in the presence of a catalyst which can be a strong acid (at a level substantially below that used in the initial condensation), or a solid catalyst (diatomaceous earth, clay, zeolite). The aqueous layer remaining after the solvent extraction contains aniline hydrochloride and a minor amount of benzylamine hydrochloride and is recovered and used as part of the reactants employed in a subsequent condensation.

    摘要翻译： 在酸性催化剂的存在下，通过在最初的冷凝中使苯胺和甲醛缩合制备聚亚甲基多苯基多胺的过程，描述了改进。 该改进使得在反应结束时必须被中和的酸的量基本上减少或完全消除。 当无机酸催化剂用于冷凝时，这不会牺牲通常存在于多胺的二胺含量中的二（氨基苯基）甲烷的高含量的4,4'-异构体。 该改进包括在强酸存在下进行苯胺和甲醛的初始缩合，通常用于在多胺产物的二胺组分中获得高的4,4'-异构体含量，在反应混合物的阶段 其中苄胺形成基本上完成，在将反应混合物的苯胺和水含量调节到指定水平之后进行溶剂萃取，从溶剂萃取物中回收苄胺和过量苯胺的混合物，并将该混合物（任选地除去苯胺） 在可以是强酸（基本上低于初始缩合时使用的水平）的催化剂存在下，或者固体催化剂（硅藻土，粘土，沸石）的情况下，重排为所需的多胺产物。 溶剂萃取后残留的水层含有盐酸苯胺和少量的盐酸苄胺，并被回收并用作后续冷凝中所用反应物的一部分。

    Aminobenzyl-amides and salts thereof
    34.
    发明授权
    Aminobenzyl-amides and salts thereof 失效
    氨基苄基酰胺及其盐

    公开(公告)号：US3950393A

    公开(公告)日：1976-04-13

    申请号：US458099

    申请日：1974-04-05

    申请人： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

    发明人： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

    IPC分类号： C07C211/52 ,  A61K31/135 ,  A61K31/19 ,  C07C209/10 ,  C07C209/50 ,  C07C209/62 ,  C07C209/74 ,  C07C211/29 ,  C07C211/49 ,  C07C211/53 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C233/43 ,  C07C255/58 ,  C07D221/24 ,  C07D295/135 ,  C07C101/48 ,  C07C101/68

    CPC分类号： C07D295/135 ,  A61K31/135 ,  A61K31/19 ,  C07D221/24 ,  Y10S514/849

    摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##EQU1## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-ulcergenics, secretolytics, antitussive, and stimulants of the production of the surfactant or antiatelectasis factor of the alveoli.

    摘要翻译： 式WHEREIN R 1的化合物是氢或脂族或芳族羧酸酰基，R 2是氢，氯或溴，R 3是氟，1至4个碳原子的烷基，三氟甲基，氰基，氨基甲酰基，羧基，烷氧基，烷氧基，乙酰基， 羟乙基或R6 -CH2-N ANGLE R7，其中R6和R7各自为烷基，环烷基，羟基 - 环烷基或彼此连接的氮原子，吡咯烷基，哌啶子基或吗啉代，R4和R5各自为 氢，1至5个碳原子的烷基，一或二羟基（1至5个碳原子的烷基），2至4个碳原子的烯基，5至7个碳原子的环烷基，一或二羟基（环烷基 5至7个碳原子），苄基，吗啉代羰基甲基或彼此连接的氮原子，吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-甲基哌嗪基或卡宾多，以及非毒性，药理学上可接受的 其添加量： 化合物作为其生物利用作为抗生素，秘密，抗生素和生物活性成分或抗生素因子的有效途径。