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公开(公告)号：US20130130926A1
公开(公告)日：2013-05-23
申请号：US13527072
申请日：2012-06-19
Applicant: Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
Inventor： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
IPC: G01N33/543
CPC classification number: G01N33/543 , B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S436/805 , Y10S436/809
Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
Abstract translation: 本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。
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公开(公告)号：US08417465B2
公开(公告)日：2013-04-09
申请号：US12726140
申请日：2010-03-17
Applicant: Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
Inventor： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
IPC: G01N33/48
CPC classification number: G01N33/5082 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/56972
Abstract: An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
Abstract translation: 用于测定用于药物和药物递送载体筛选的血脑屏障性质的装置和方法，包括具有分隔内腔和组织空间的间隙的微流体装置，从而能够形成类似于使用内皮细胞和脑细胞的体内条件的紧密连接。
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公开(公告)号：US20130045967A1
公开(公告)日：2013-02-21
申请号：US13614046
申请日：2012-09-13
Applicant: Vineet Gupta , M. Amin Arnaout
Inventor： Vineet Gupta , M. Amin Arnaout
IPC: A61K31/427 , A61K31/421 , A61P29/00 , A61K31/4985 , A61K31/437 , A61K31/426 , A61K31/5415
CPC classification number: G01N33/5032 , C07C233/81 , C07C251/20 , C07C311/39 , C07C2601/14 , C07D213/85 , C07D239/48 , C07D249/10 , C07D263/46 , C07D265/34 , C07D277/14 , C07D277/36 , C07D277/42 , C07D277/54 , C07D277/72 , C07D311/16 , C07D333/22 , C07D333/68 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D498/04 , C07D513/18
Abstract: The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.
Abstract translation: 该应用描述了用于鉴定整合素CD11b / CD18的小分子调节剂和能够调节该受体活性的小分子的测定法。 这些化合物可用于某些实施方案中用于治疗选自炎症，免疫相关疾病，癌症，缺血再灌注损伤，中风，与血管损伤相关的新内膜增厚，大疱性类天疱疮，新生儿梗阻性肾病和心血管疾病的疾病或病症， 或在其它实施方案中用于治疗选自免疫缺陷，获得性免疫缺陷综合征（AIDS），髓过氧化物酶缺乏症，威斯科特 - 奥德里奇综合征，慢性肉芽肿病，超IgM综合征，白细胞粘附缺陷，Chediak-Higashi综合征 ，和严重的联合免疫缺陷。
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公开(公告)号：US08372592B2
公开(公告)日：2013-02-12
申请号：US13240406
申请日：2011-09-22
Applicant: Lance G. Laing , Rafael Fernandez , Rick Wagner
Inventor： Lance G. Laing , Rafael Fernandez , Rick Wagner
IPC: G01N33/53
CPC classification number: G01N33/53 , G01N21/4788 , G01N21/7703 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54373
Abstract: The invention provides methods of detecting a change in cell growth patterns.
Abstract translation: 本发明提供了检测细胞生长模式变化的方法。
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公开(公告)号：US20130035257A1
公开(公告)日：2013-02-07
申请号：US13567801
申请日：2012-09-10
Applicant: Linfen YU , Karen C. CHEUNG
Inventor： Linfen YU , Karen C. CHEUNG
CPC classification number: C12N11/04 , B01J2219/00527 , B01J2219/00621 , B01J2219/00659 , B01J2219/00743 , B01L3/502753 , B01L2200/0668 , B01L2300/069 , B01L2300/0816 , B01L2400/086 , C40B60/08 , G01N33/5032
Abstract: Methods of isolating at least one cell of interest, methods of making fixed arrays, arrays comprising a glass substrate bonded to a patterned siloxane structure having inlets, outlets and microchannels, array kits, and methods of making microfluidic apparati are provided in the present application.
Abstract translation: 在本申请中提供了分离至少一个感兴趣的细胞的方法，制备固定阵列的方法，包含结合到具有入口，出口和微通道的图案化硅氧烷结构的玻璃基底的阵列，阵列试剂盒和制备微流体装置的方法。
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Patent Agency Ranking
公开(公告)号：US08268816B2
公开(公告)日：2012-09-18
申请号：US12456692
申请日：2009-06-19
Applicant: Vineet Gupta , M. Amin Arnaout
Inventor： Vineet Gupta , M. Amin Arnaout
IPC: C07D415/00 , C07D277/20 , C07D263/30 , A61K31/535 , A61K31/54
CPC classification number: G01N33/5032 , C07C233/81 , C07C251/20 , C07C311/39 , C07C2601/14 , C07D213/85 , C07D239/48 , C07D249/10 , C07D263/46 , C07D265/34 , C07D277/14 , C07D277/36 , C07D277/42 , C07D277/54 , C07D277/72 , C07D311/16 , C07D333/22 , C07D333/68 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D498/04 , C07D513/18
Abstract: The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. For example, one such compound useful as an agonist of integrin CD11b/CD18 is the compound of Formula (I): Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.
Abstract translation: 该应用描述了用于鉴定整合素CD11b / CD18的小分子调节剂和能够调节该受体活性的小分子的测定法。 例如，可用作整联蛋白CD11b / CD18的激动剂的一种这样的化合物是式（I）的化合物：这些化合物可用于某些实施方案中用于治疗选自炎症，免疫相关疾病，癌症，局部缺血的疾病或病症 - 再灌注损伤，中风，与血管损伤相关的新内膜增厚，大疱性类天疱疮，新生儿梗阻性肾病和心血管疾病，或在其它实施方案中用于治疗选自免疫缺陷，获得性免疫缺陷综合征（AIDS），髓过氧化物酶 Wiskott-Aldrich综合征，慢性肉芽肿病，超IgM综合征，白细胞粘连缺陷，Chediak-Higashi综合征和严重联合免疫缺陷。
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公开(公告)号：US20120195880A1
公开(公告)日：2012-08-02
申请号：US13326180
申请日：2011-12-14
Applicant: Ben A. Barres , Beth A. Stevens
Inventor： Ben A. Barres , Beth A. Stevens
IPC: A61K39/395 , A61P25/28 , G01N33/567 , A61P25/00 , G01N33/566 , C12Q1/68
CPC classification number: G01N33/5058 , A61K31/00 , A61K31/727 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K16/18 , C07K2317/76 , G01N33/5032 , G01N33/564 , G01N33/6872 , G01N33/6896 , G01N2333/4716 , G01N2500/04 , G01N2800/28 , G01N2800/2821 , A61K2300/00
Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
Abstract translation: C1q显示在神经元中表达，其中它作为突触消除的信号。 提供了用于保护或治疗患有突触损失不良反应的个体的方法。 这些发现对各种临床状况（包括阿尔茨海默氏病）具有广泛的影响。
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38.发明授权Methods and kits for distinguishing between specific and non-specific protein associations 有权用于区分特异性和非特异性蛋白质关联的方法和试剂盒公开(公告)号：US08227198B2
公开(公告)日：2012-07-24
申请号：US13106490
申请日：2011-05-12
Applicant: Brian T. Chait , Alan J. Tackett , Jeffrey A. DeGrasse , Marlene Oeffinger , Michael P. Rout , Matthew D. Sekedat
Inventor： Brian T. Chait , Alan J. Tackett , Jeffrey A. DeGrasse , Marlene Oeffinger , Michael P. Rout , Matthew D. Sekedat
IPC: G01N33/53
CPC classification number: G01N33/5023 , G01N33/5032 , G01N33/60 , G01N33/6845 , G01N33/6848
Abstract: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific. The method comprises (a) providing a first sample of the cells in which the given protein contains a tag, (b) providing a second sample of the same cells, wherein the given protein and the other proteins are metabolically labeled, and wherein neither the given protein nor the other proteins are tagged, (c) mixing and lysing the first cell sample and the second cell sample to provide a mixture of proteins, (d) binding the tag of the given protein to a substrate, (e) isolating proteins associated with the tagged given protein bound to the substrate, whereby the associated proteins comprise: (i) proteins specifically associated with the tagged given protein, (ii) proteins non-specifically associated with the tagged given protein, or (iii) a combination thereof, (f) determining whether each associated protein is unlabeled or a mixture of labeled and unlabeled proteins, wherein if the associated protein is not labeled, then that protein was specifically associated in the cell with the tagged given protein.
Abstract translation: 本发明是确定细胞中给定蛋白质和其它蛋白质之间的缔合是否是特异性的方法。 该方法包括（a）提供其中给定蛋白质含有标签的细胞的第一样品，（b）提供相同细胞的第二样品，其中所述给定蛋白质和其它蛋白质代谢标记，并且其中 （c）混合和裂解第一细胞样品和第二细胞样品以提供蛋白质的混合物，（d）将给定蛋白质的标签与底物结合，（e）分离蛋白质 与标记的给定蛋白质结合至底物，其中相关蛋白质包含：（i）与标记的给定蛋白质特异性相关的蛋白质，（ii）与标记的给定蛋白质非特异性相关的蛋白质，或（iii）其组合 ，（f）确定每个相关蛋白是否未标记，或标记蛋白和未标记蛋白质的混合物，其中如果相关蛋白未被标记，那么该蛋白质与标记特异性结合在细胞中 给定蛋白质。
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39.发明申请HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN 有权用于确定合同功能的高通量测量及其使用的装置公开(公告)号：US20120142556A1
公开(公告)日：2012-06-07
申请号：US13318227
申请日：2010-04-30
Applicant: Kevin Kit Parker , Adam Walter Feinberg , Patrick W. Alford , Anna Grosberg , Mark D. Brigham , Josue Adrian Goss
Inventor： Kevin Kit Parker , Adam Walter Feinberg , Patrick W. Alford , Anna Grosberg , Mark D. Brigham , Josue Adrian Goss
CPC classification number: G01N33/5061 , C12Q1/025 , C40B30/06 , G01N33/5032 , G01N33/5088 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
Abstract translation: 本发明提供用于鉴定调节收缩功能的化合物的高通量测定，以及适用于这些测定的装置。
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公开(公告)号：US20120040866A1
公开(公告)日：2012-02-16
申请号：US13240406
申请日：2011-09-22
Applicant: Lance G. Laing , Rafael Fernandez , Rick Wagner
Inventor： Lance G. Laing , Rafael Fernandez , Rick Wagner
CPC classification number: G01N33/53 , G01N21/4788 , G01N21/7703 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54373
Abstract: The invention provides methods of detecting a change in cell growth patterns.
Abstract translation: 本发明提供了检测细胞生长模式变化的方法。
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