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    MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
    6.
    发明申请
    MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权
    作为IRAK4抑制剂治疗炎性疾病的大环化合物

    公开(公告)号：US20160002265A1

    公开(公告)日：2016-01-07

    申请号：US14770030

    申请日：2014-03-14

    申请人： BIOGEN MA INC.

    发明人： Tracy Jenkins ,  Jeffery Vessels

    IPC分类号： C07D513/22 ,  C07D471/22 ,  C07D498/22 ,  C07D498/18 ,  C07D513/18

    CPC分类号： C07D513/22 ,  C07D471/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18

    摘要： Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R4 is absent, heteroarylene, arylene, C1-3 alkylene, or R4 and R3 taken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; R5 is absent, C(0)NR51, NR52 or 0; R6 is C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an 0, S, SO, SO2 or NR61, and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; R7 is absent, NR71 or O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases.

    摘要翻译： 提供式（I）的化合物或其药学上可接受的盐，其中i.a. 环A是亚苯基或5-至6-元杂亚芳基; 环B是亚苯基，5-至6-元杂环亚烷基或5-至6-元杂芳基; R4不存在，杂亚芳基，亚芳基，C 1-3亚烷基，或者R 4和R 3与它们所连接的氮一起形成3-至7-元杂环烷基环; R5不存在，C（0）NR51，NR52或0; R 6是C 2-10亚烷基或亚烯基，其中亚烷基链中的一个或两个碳原子任选被0，S，SO，SO 2或NR 61取代，并且其中亚烷基链中的两个碳原子任选连接 通过两个或三个碳原子的亚烷基链形成5-至7-元环; R7不存在，NR71或O.化合物是可用于治疗炎性疾病的IRAK4抑制剂。

    HETEROCYCLIC COMPOUND AND USE THEREOF
    10.
    发明申请
    HETEROCYCLIC COMPOUND AND USE THEREOF 有权
    杂环化合物及其用途

    公开(公告)号：US20150051197A1

    公开(公告)日：2015-02-19

    申请号：US14377106

    申请日：2013-02-07

    申请人： Takeda Pharmaceutical Company Limited

    发明人： Masashi Toyofuki ,  Shinji Nakamura ,  Eiji Honda

    IPC分类号： C07D513/08 ,  C07D513/04

    CPC分类号： C07D513/08 ,  C07D513/04 ,  C07D513/18

    摘要： Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease, attention deficit hyperactivity disorder (ADHD) and the like. The compound represented by formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has an AMPA receptor function enhancing action, and is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and the like.

    摘要翻译： 本发明提供具有AMPA受体功能增强作用的化合物，可用作抑郁，精神分裂症，阿尔茨海默病，注意力缺陷多动障碍（ADHD）等的预防或治疗药物。 由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐具有AMPA受体功能增强作用，并且可用作抑郁症，精神分裂症，阿尔茨海默病或注意力缺陷的预防或治疗药物 多动症（ADHD）等。