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    MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
    3.
    发明申请
    MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权
    作为IRAK4抑制剂治疗炎性疾病的大环化合物

    公开(公告)号：US20160002265A1

    公开(公告)日：2016-01-07

    申请号：US14770030

    申请日：2014-03-14

    Applicant: BIOGEN MA INC.

    Inventor： Tracy Jenkins ,  Jeffery Vessels

    IPC: C07D513/22 ,  C07D471/22 ,  C07D498/22 ,  C07D498/18 ,  C07D513/18

    CPC classification number: C07D513/22 ,  C07D471/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18

    Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R4 is absent, heteroarylene, arylene, C1-3 alkylene, or R4 and R3 taken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; R5 is absent, C(0)NR51, NR52 or 0; R6 is C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an 0, S, SO, SO2 or NR61, and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; R7 is absent, NR71 or O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases.

    Abstract translation: 提供式（I）的化合物或其药学上可接受的盐，其中i.a. 环A是亚苯基或5-至6-元杂亚芳基; 环B是亚苯基，5-至6-元杂环亚烷基或5-至6-元杂芳基; R4不存在，杂亚芳基，亚芳基，C 1-3亚烷基，或者R 4和R 3与它们所连接的氮一起形成3-至7-元杂环烷基环; R5不存在，C（0）NR51，NR52或0; R 6是C 2-10亚烷基或亚烯基，其中亚烷基链中的一个或两个碳原子任选被0，S，SO，SO 2或NR 61取代，并且其中亚烷基链中的两个碳原子任选连接 通过两个或三个碳原子的亚烷基链形成5-至7-元环; R7不存在，NR71或O.化合物是可用于治疗炎性疾病的IRAK4抑制剂。

    Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
    8.
    发明授权
    Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases 有权

    公开(公告)号：US09617282B2

    公开(公告)日：2017-04-11

    申请号：US14770030

    申请日：2014-03-14

    Applicant: BIOGEN MA INC.

    Inventor： Tracy Jenkins ,  Jeffery Vessels

    IPC: C07D498/18 ,  C07D498/22 ,  C07D513/18 ,  C07D513/22 ,  C07D471/22

    CPC classification number: C07D513/22 ,  C07D471/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18

    Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R4 is absent, heteroarylene, arylene, C1-3 alkylene, or R4 and R3 taken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; R5 is absent, C(O)NR51, NR52 or O; R6 is C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an O, S, SO, SO2 or NR61, and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; R7 is absent, NR71 or O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases.

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