公开(公告)号：US20170204093A1

公开(公告)日：2017-07-20

申请号：US15326740

申请日：2015-07-17

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07B59/00 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D471/04 ,  A61K31/416 ,  A61P13/12 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US11427561B2

公开(公告)日：2022-08-30

申请号：US16071200

申请日：2017-01-18

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin M. Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffrey Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph P. Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield ,  Nathan Genung

IPC: C07D401/14 ,  A61K45/06

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

公开(公告)号：US20210188809A1

公开(公告)日：2021-06-24

申请号：US16071200

申请日：2017-01-18

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffrey Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph P. Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield ,  Nathan Genung

IPC: C07D401/14 ,  A61K45/06

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.

公开(公告)号：US10577367B2

公开(公告)日：2020-03-03

申请号：US16271497

申请日：2019-02-08

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D401/14 ,  C07D487/04 ,  A61K31/416 ,  A61K31/437 ,  A61K31/44 ,  A61P13/12 ,  A61P19/02 ,  C07D471/04 ,  C07D405/14 ,  C07D413/14 ,  C07B59/00 ,  C07D401/12 ,  C07D417/14

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20190248787A1

公开(公告)日：2019-08-15

申请号：US16271497

申请日：2019-02-08

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  A61K31/416 ,  C07D401/12 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14

Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10246456B2

公开(公告)日：2019-04-02

申请号：US15326740

申请日：2015-07-17

Applicant: BIOGEN MA INC.

Inventor： Timothy Chan ,  Kevin Guckian ,  Tracy Jenkins ,  Jermaine Thomas ,  Jeffery Vessels ,  Gnanasambandam Kumaravel ,  Robert Meissner ,  Joseph Lyssikatos ,  Brian Lucas ,  Irina Leaf ,  Jeremy Duffield

IPC: C07D471/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  A61K31/416 ,  A61P13/12 ,  C07B59/00 ,  C07D401/12 ,  C07D417/14

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.