公开(公告)号：US3746730A

公开(公告)日：1973-07-17

申请号：US3746730D

申请日：1970-12-17

Applicant: HOFFMANN LA ROCHE

Inventor： MARBET R

IPC: A61K31/59 ,  C07C51/16 ,  C07C69/00 ,  C07C403/00 ,  C08H17/36

CPC classification number: C07C403/20 ,  A61K31/59 ,  C07C51/16 ,  C07C2601/16 ,  C07C57/03 ,  C07C57/26

Abstract: A PROCESS FOR PREPARING POLYENE ACIDS FROM POLYENE ALCOHOLS OR ESTERS THEREOF BY A SINGLE OXIDATION REACTION BY SILVER(1)OXIDE IN THE PRESENCE OF AN ALKALI.

公开(公告)号：US3317590A

公开(公告)日：1967-05-02

申请号：US32305363

申请日：1963-11-12

Applicant: UNIVERSAL OIL PROD CO

Inventor： LOUIS SCHMERLING

IPC: C07C51/353

CPC classification number: C07C51/353 ,  C07C57/03 ,  C07C57/26 ,  C07C57/04 ,  C07C57/13

公开(公告)号：US3251869A

公开(公告)日：1966-05-17

申请号：US24825262

申请日：1962-12-31

Applicant: HERCULES POWDER CO LTD

Inventor： PUTNAM STEARNS T ,  SPECK RHOADS M ,  WEISGERBER CYRUS A

IPC: C07C57/02 ,  C07C57/26 ,  C08F20/64 ,  C11D13/00

CPC classification number: C07C57/02 ,  C07C57/26 ,  C08F20/64 ,  C11D13/00 ,  Y10S526/911

公开(公告)号：US3075010A

公开(公告)日：1963-01-22

申请号：US8337361

申请日：1961-01-18

Applicant: UNIVERSAL OIL PROD CO

Inventor： LOUIS SCHMERLING ,  TOEKELT WALTER G

IPC: C07C51/353 ,  C07C51/41 ,  C07C53/126 ,  C07C57/03 ,  C07C57/26 ,  C07C57/30

CPC classification number: C07C57/30 ,  C07C51/353 ,  C07C51/41 ,  C07C53/126 ,  C07C57/03 ,  C07C57/26 ,  Y02P20/582

公开(公告)号：US2352606A

公开(公告)日：1944-07-04

申请号：US28740839

申请日：1939-07-29

Applicant: KURT ALDER ,  ERWIN WINDEMUTH

Inventor： KURT ALDER ,  ERWIN WINDEMUTH

IPC: C07C2/50 ,  C07C35/22 ,  C07C35/28

CPC classification number: C07C35/22 ,  C07C17/30 ,  C07C29/44 ,  C07C29/46 ,  C07C35/28 ,  C07C41/30 ,  C07C51/353 ,  C07C209/60 ,  C07C253/30 ,  C07C331/22 ,  C07C2601/16 ,  C07C2602/42 ,  C07C2603/88 ,  C07C22/02 ,  C07C211/25 ,  C07C255/31 ,  C07C33/14 ,  C07C33/34 ,  C07C43/23 ,  C07C57/26

公开(公告)号：US20180327343A1

公开(公告)日：2018-11-15

申请号：US15977638

申请日：2018-05-11

Applicant: Samantha E. Shockley ,  John C. Hethcox ,  Brian M. Stoltz

Inventor： Samantha E. Shockley ,  John C. Hethcox ,  Brian M. Stoltz

IPC: C07C51/08 ,  C07C57/03 ,  C07C67/22 ,  C07C69/52 ,  C07C231/18 ,  C07C233/09 ,  B01J31/12 ,  B01J31/18

CPC classification number: C07C51/08 ,  B01J31/12 ,  B01J31/122 ,  B01J31/186 ,  B01J2231/44 ,  B01J2531/827 ,  C07B2200/07 ,  C07C57/03 ,  C07C67/00 ,  C07C67/22 ,  C07C69/52 ,  C07C201/12 ,  C07C231/18 ,  C07C233/09 ,  C07C253/30 ,  C07C2601/14 ,  C07C2601/16 ,  C07C255/38 ,  C07C205/57 ,  C07C57/42 ,  C07C57/60 ,  C07C59/48 ,  C07C57/26 ,  C07C69/65

Abstract: The present disclosure provides methods for enantioselective synthesis of acyclic α-quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.

公开(公告)号：US09732056B2

公开(公告)日：2017-08-15

申请号：US14854705

申请日：2015-09-15

Applicant: Givaudan, S.A.

Inventor： Fridtjof Schröder ,  Urs Mueller ,  Jurg Daniel Oetiker

IPC: C07C403/20 ,  C07C69/608 ,  C07C51/38 ,  C07C57/26 ,  C07C67/475 ,  C07C67/32 ,  C07D307/92

CPC classification number: C07D307/92 ,  C07C51/38 ,  C07C57/26 ,  C07C67/32 ,  C07C67/475 ,  C07C69/608 ,  C07C403/20 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/48

Abstract: Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2

公开(公告)号：US20170112792A1

公开(公告)日：2017-04-27

申请号：US15126714

申请日：2015-03-19

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Kun Ping LU ,  Xiao Zhen ZHOU ,  Shuo WEI

IPC: A61K31/203 ,  A61K45/06 ,  C12Q1/533 ,  C07C57/26

CPC classification number: A61K31/203 ,  A61K38/21 ,  A61K45/06 ,  C07C57/26 ,  C12Q1/533 ,  G01N2333/99 ,  G01N2500/04 ,  G01N2800/24 ,  G01N2800/307 ,  G01N2800/7028 ,  G16B35/00 ,  G16C20/60 ,  Y02A50/414 ,  A61K2300/00

Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of identifying the same. The invention also provides methods of treating a condition selected from the group consisting of a proliferative disorder, an autoimmune disease, and an addiction condition characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another therapeutic compound. The invention also features a co-crystal including Pin1 and a retinoic acid compound. Finally, the invention also provides methods of developing and identifying enhanced Pin1-targeted ATRA-related compounds based on the newly defined unique binding pockets in the Pin1 active site revealed from the co-crystal structure, structure-activity relationship, and structural modeling.

公开(公告)号：US20160151322A1

公开(公告)日：2016-06-02

申请号：US14982476

申请日：2015-12-29

Applicant: MEIJI SEIKA KAISHA, LTD.

Inventor： Ken Chikauchi ,  Mizuyo Ida ,  Takao Abe ,  Yukiko Hiraiwa ,  Akihiro Morinaka ,  Toshiaki Kudo

IPC: A61K31/225 ,  C07C69/618 ,  A61K31/235 ,  C07C69/608 ,  A61K31/215 ,  C07D213/55 ,  A61K31/4406 ,  C07D295/15 ,  A61K31/4453 ,  C07D211/46 ,  A61K31/445 ,  C07C69/732 ,  C07C69/734 ,  C07C323/54 ,  C07D295/16 ,  A61K31/5375 ,  A61K31/495 ,  C07C235/84 ,  A61K31/166 ,  C07D233/60 ,  A61K31/4164 ,  C07D207/12 ,  A61K31/40 ,  C07C279/14 ,  A61K31/24 ,  C07D309/06 ,  A61K31/351 ,  C07C69/60

CPC classification number: A61K31/225 ,  A61K31/166 ,  A61K31/194 ,  A61K31/215 ,  A61K31/235 ,  A61K31/24 ,  A61K31/351 ,  A61K31/40 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4406 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/546 ,  A61K45/06 ,  C07C51/00 ,  C07C57/13 ,  C07C57/145 ,  C07C57/26 ,  C07C57/42 ,  C07C57/50 ,  C07C59/52 ,  C07C59/64 ,  C07C59/70 ,  C07C69/593 ,  C07C69/60 ,  C07C69/608 ,  C07C69/618 ,  C07C69/732 ,  C07C69/734 ,  C07C217/22 ,  C07C233/65 ,  C07C235/20 ,  C07C235/84 ,  C07C237/22 ,  C07C279/08 ,  C07C279/14 ,  C07C323/54 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/12 ,  C07D211/46 ,  C07D211/60 ,  C07D213/55 ,  C07D213/80 ,  C07D233/60 ,  C07D295/15 ,  C07D295/16 ,  C07D295/192 ,  C07D309/06 ,  Y02A50/473 ,  Y02A50/475 ,  A61K2300/00

Abstract: A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

Abstract translation: 公开了一种新的金属 - β-内酰胺酶抑制剂，其用作抑制β-内酰胺抗生素灭活和回收抗细菌活性的药物。 具有通式（I）的马来酸衍生物具有金属 - β-内酰胺酶抑制活性。 通过将通式（I）的化合物与β-内酰胺抗生素结合，可以回收抗β-生物反相抗生素对产生金属 - β-内酰胺酶的细菌的抗菌活性。

公开(公告)号：US20160096817A1

公开(公告)日：2016-04-07

申请号：US14846016

申请日：2015-09-04

Applicant: Allergan, Inc.

Inventor： Yariv Donde ,  Jeremiah H. Nguyen ,  Karen M. Kedzie ,  Daniel W. Gil ,  John E. Donello ,  Wha-Bin Im

IPC: C07D333/56 ,  C07C57/26 ,  C07C57/48 ,  C07C69/738

CPC classification number: C07D333/56 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07C57/26 ,  C07C57/48 ,  C07C59/90 ,  C07C69/732 ,  C07C69/738 ,  C07D333/62 ,  C07D409/08

Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.