公开(公告)号：US20130116685A1

公开(公告)日：2013-05-09

申请号：US13619950

申请日：2012-09-14

Applicant: Mark Deem ,  Hanson Gifford, III ,  Denise Demarais ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

Inventor： Mark Deem ,  Hanson Gifford, III ,  Denise Demarais ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61B18/14

CPC classification number: A61N1/36007 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/0412 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

公开(公告)号：US20120136322A1

公开(公告)日：2012-05-31

申请号：US13151001

申请日：2011-06-01

Applicant: Yair Alster ,  Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

Inventor： Yair Alster ,  Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

IPC: A61F9/00 ,  A61M35/00

CPC classification number: A61F9/0026 ,  A61F9/0017 ,  A61K9/0051 ,  A61K31/19 ,  A61K31/335 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/43 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/002

Abstract: A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

Abstract translation: 治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。 眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。 第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。 该第一结构将治疗系统的附着维持在眼前部至少三十天。 在一些实施例中，第一结构保持恒定的尺寸和形状，例如。 环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上结膜，以将植入物保持在泪液和/或针对眼睛的组织。

公开(公告)号：US20110226238A1

公开(公告)日：2011-09-22

申请号：US12885199

申请日：2010-09-17

Applicant: Michael Barrett ,  Michael Hendricksen ,  Alan R. Rapacki ,  Ronald R. Hundertmark ,  Jeffrey J. Dolin ,  Robert M. George ,  Antony J. Fields ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Ronald French ,  Douglas Sutton

Inventor： Michael Barrett ,  Michael Hendricksen ,  Alan R. Rapacki ,  Ronald R. Hundertmark ,  Jeffrey J. Dolin ,  Robert M. George ,  Antony J. Fields ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Ronald French ,  Douglas Sutton

IPC: A61M16/20

CPC classification number: A61B17/12022 ,  A61B17/12104 ,  A61B17/12172 ,  A61F2/2412 ,  A61F2002/043

Abstract: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.

Abstract translation: 公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序，确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。

公开(公告)号：US20100255061A1

公开(公告)日：2010-10-07

申请号：US12696678

申请日：2010-01-29

Applicant: Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

Inventor： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

IPC: A61F9/00 ,  A61K39/395 ,  A61P27/02 ,  A61K31/5575 ,  A61K31/58 ,  A61F2/14 ,  B23P17/04

CPC classification number: G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

Abstract translation: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

公开(公告)号：US20090275899A1

公开(公告)日：2009-11-05

申请号：US12467240

申请日：2009-05-15

Applicant: Mark E. Deem ,  Hanson S. Gifford, III ,  Douglas Sutton

Inventor： Mark E. Deem ,  Hanson S. Gifford, III ,  Douglas Sutton

IPC: A61M5/32 ,  A61B18/18

CPC classification number: A61N7/00 ,  A61B2017/00747 ,  A61B2017/22008 ,  A61K9/0009 ,  A61K41/0028 ,  A61M37/0092 ,  A61M2037/003 ,  A61N1/0412 ,  A61N1/0492 ,  A61N1/327 ,  A61N2007/0008 ,  A61N2007/0039

Abstract: An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.

Abstract translation: 公开了一种在低声压超声波范围内使用声波处理皮下组织的装置和方法。 该方法包括注射增强剂，其中通过具有在不存在增强剂的情况下不产生组织空泡的能力的超声波产生皮下组织的破坏和皮下空泡生物效应。 该装置和使用方法可用于治疗包括脂肪团，脂肪瘤和肿瘤在内的皮下异常。

公开(公告)号：US07591674B2

公开(公告)日：2009-09-22

申请号：US11948013

申请日：2007-11-30

Applicant: Stephen Douglas Sutton

Inventor： Stephen Douglas Sutton

IPC: H01R11/00

CPC classification number: H01R31/06 ,  B60R16/0207 ,  H01H1/5866 ,  H01H50/14 ,  H01R27/00

Abstract: The invented apparatus is designed for use within a vehicle's electrical system. The apparatus electrically couples a plug having a first electrical contact configuration with a relay having a different electrical contact configuration. The apparatus provides an easy and inexpensive solution for replacing relay's that have different electrical contact configurations.

Abstract translation: 本发明的设备被设计用于在车辆的电气系统内使用。 该装置将具有第一电接触构造的插头与具有不同电接触构造的继电器电耦合。 该设备为替代具有不同电接触配置的继电器提供了一种简单而便宜的解决方案。

公开(公告)号：US20070213740A1

公开(公告)日：2007-09-13

申请号：US11801474

申请日：2007-05-10

Applicant: Mark Deem ,  Douglas Sutton ,  Hanson Gifford ,  Benard Andreas ,  Ronald French

Inventor： Mark Deem ,  Douglas Sutton ,  Hanson Gifford ,  Benard Andreas ,  Ronald French

IPC: A61B17/122

CPC classification number: A61B17/1114 ,  A61B17/00234 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/122 ,  A61B2017/00557 ,  A61B2017/306 ,  A61B2090/395 ,  A61F5/0083 ,  A61F5/0086

Abstract: Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods

公开(公告)号：US20070118158A1

公开(公告)日：2007-05-24

申请号：US11654709

申请日：2007-01-18

Applicant: Mark Deem ,  Douglas Sutton ,  Hanson Gifford ,  Bernard Andreas ,  Ronald French

Inventor： Mark Deem ,  Douglas Sutton ,  Hanson Gifford ,  Bernard Andreas ,  Ronald French

IPC: A61B17/08

CPC classification number: A61B17/1114 ,  A61B17/00234 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/122 ,  A61B2017/00557 ,  A61B2017/306 ,  A61B2090/395 ,  A61F5/0083 ,  A61F5/0086

Abstract: Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

Abstract translation: 本文描述了各种肥胖治疗工具和方法，以及用于其它胃相关疾病例如GERD的治疗。 治疗包括减小胃袋的尺寸以限制热量摄入以及提供较早的饱腹感。 这可以通过在胃内部直接从胃内部产生较小的胃袋来完成。 较小的袋可以通过使用单独的锚定装置，旋转探针或体积减小装置来制造。 还可以进行幽门成形术以使幽门括约肌无能力。 另外可以使用无创伤的磁性吻合装置进行胃旁路手术，使得糖和脂肪在绕过胃时直接通过肠。 这些程序中的许多可以以各种组合进行。 治疗可能会通过阻止摄入高热量食物而产生强制行为改变。

公开(公告)号：US20070112364A1

公开(公告)日：2007-05-17

申请号：US11529201

申请日：2006-09-28

Applicant: Craig Gerbi ,  Gary Weller ,  Jamy Gannoe ,  Douglas Sutton ,  Andrew Hancock ,  Gilbert Mata

Inventor： Craig Gerbi ,  Gary Weller ,  Jamy Gannoe ,  Douglas Sutton ,  Andrew Hancock ,  Gilbert Mata

IPC: A61B17/08

CPC classification number: A61B17/29 ,  A61B17/07207 ,  A61B2017/07214 ,  A61B2017/081 ,  A61B2017/2905 ,  A61B2017/306

Abstract: A single fold system for tissue approximation and fixation is described herein. The devices are advanced in a minimally invasive manner within a patient's body to create at least one fold within a hollow body organ. The system comprises a tissue acquisition and folding device and a tissue stapling or fixation device, each of which is used together as a system. The acquisition device is used to approximate a single fold of tissue from within the hollow body organ and the stapling device is advanced through a main lumen defined through the acquisition device and is used to affix the tissue. The stapling device is keyed to maintain its rotational orientation relative to the acquisition device and to provide the user positional information of the stapling device. The acquisition device is also configured to provide lateral stability to the stapling device prior to the stapling device being clamped onto tissue.

公开(公告)号：US20060276852A1

公开(公告)日：2006-12-07

申请号：US11368577

申请日：2006-03-06

Applicant: Denise Demarais ,  Hanson Gifford ,  Mark Deem ,  Douglas Sutton ,  Howard Levin ,  Mark Gelfand

Inventor： Denise Demarais ,  Hanson Gifford ,  Mark Deem ,  Douglas Sutton ,  Howard Levin ,  Mark Gelfand

IPC: A61N1/18

CPC classification number: A61N1/05 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/1082 ,  A61N1/0551 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/40

Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Abstract translation: 提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗高血压的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和 /或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。 在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中，这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。