公开(公告)号：US10166142B2

公开(公告)日：2019-01-01

申请号：US14236863

申请日：2012-08-03

申请人： Eugene De Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

发明人： Eugene De Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K31/382 ,  A61K31/407 ,  A61K31/519

摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

公开(公告)号：US20140358125A1

公开(公告)日：2014-12-04

申请号：US14236863

申请日：2012-08-03

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

IPC分类号： A61F9/00 ,  A61K31/382

CPC分类号： A61F9/0017 ,  A61F2250/0031 ,  A61F2250/0068 ,  A61K9/0051 ,  A61K31/382 ,  A61K31/407 ,  A61K31/519 ,  F04C2270/041

摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

摘要翻译： 一种能够释放治疗剂的治疗装置，所述治疗剂包括与包含储存器的容器相连的多孔结构。 贮存器可以包含一定量的体积，当耦合到多孔结构并且植入患者体内时，释放处理量的治疗剂延长时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。

公开(公告)号：US20140031769A1

公开(公告)日：2014-01-30

申请号：US13988298

申请日：2011-11-18

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson ,  Blaine Bueche

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson ,  Blaine Bueche

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/1652 ,  A61K31/573

摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.

摘要翻译： 治疗剂的可注射制剂可以包含治疗剂和稳定剂，使得当治疗剂从治疗装置释放时，大部分稳定剂保留在治疗装置中以稳定治疗剂。 可注射制剂可以包含一种或多种粘合剂颗粒或可侵蚀材料颗粒，使得可以将制剂注射到治疗装置中。 结合剂颗粒可以可逆地结合治疗剂以调节治疗剂的释放，并且可侵蚀的材料颗粒可以产生酸的质子，以增加治疗剂的稳定性并且可以调节治疗剂的释放。 治疗剂可以与稳定剂，结合剂颗粒或可侵蚀颗粒中的一种或多种组合以增加治疗剂的稳定性并且可以调节释放。

公开(公告)号：US20130324942A1

公开(公告)日：2013-12-05

申请号：US13814464

申请日：2011-08-05

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61K9/0051

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the 188 second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第188侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。

公开(公告)号：US20130165860A1

公开(公告)日：2013-06-27

申请号：US13615229

申请日：2012-09-13

申请人： Darren Doud ,  Randolph E. Campbell ,  Signe Erickson ,  K. Angela MacFarlane ,  Mike Barrett ,  Christina Skieller ,  David Batten ,  Greg Stine ,  Eugene de Juan, JR. ,  Douglas Sutton ,  Kathleen Cogan Farinas

发明人： Darren Doud ,  Randolph E. Campbell ,  Signe Erickson ,  K. Angela MacFarlane ,  Mike Barrett ,  Christina Skieller ,  David Batten ,  Greg Stine ,  Eugene de Juan, JR. ,  Douglas Sutton ,  Kathleen Cogan Farinas

IPC分类号： A61M5/46 ,  A61F9/00

CPC分类号： A61F9/0008 ,  A61F9/0017 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/3202 ,  A61M5/3291 ,  A61M5/46 ,  A61M25/007 ,  A61M39/0247 ,  A61M2025/0031 ,  A61M2025/0039 ,  A61M2039/0081 ,  A61M2039/009 ,  A61M2039/027 ,  A61M2039/0276 ,  A61M2039/0294 ,  A61M2205/6045 ,  A61M2205/6054 ,  A61M2209/045 ,  A61M2210/0612

摘要： An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

摘要翻译： 注射器装置包括具有一个或多个开口的细长结构，其可定位在可植入装置的可穿透屏障附近，以便容纳可植入装置的流体。 该装置包括在针的至少一部分上延伸的针和护套。 细长结构可以包括穿透组织和可穿透屏障的远端尖端，以及靠近尖端的远端开口以将治疗流体释放到可植入腔室中。 在许多实施例中，远端尖端，远侧开口和多个开口与接合患者组织的止挡分开并限制穿透深度，使得远端开口和多个开口沿着可植入的轴线 设备提高交换效率。

公开(公告)号：US20140033800A1

公开(公告)日：2014-02-06

申请号：US13884343

申请日：2011-11-10

申请人： Kathleen Cogan Farinas ,  Cary Reich ,  Randolph E. Campbell ,  Signe Erikson ,  Michael S. Barrett

发明人： Kathleen Cogan Farinas ,  Cary Reich ,  Randolph E. Campbell ,  Signe Erikson ,  Michael S. Barrett

IPC分类号： G01N15/08

CPC分类号： G01N15/082 ,  A61F9/0017 ,  A61F2250/0068 ,  A61K9/0051 ,  A61M31/002 ,  G01N13/00 ,  G01N15/08 ,  G01N15/0826 ,  G01N2013/003

摘要： Disclosed herein are improved therapeutic devices and methods and improved porous structures and measurement apparatus for use with therapeutic devices. In many embodiments, a porous structure is measured based on diffusion of the gas through the porous structure. The gas measurement may comprise an amount of gas measured to determine a resistance of the porous structure to diffusion. The diffusion of the gas through the porous structure can be used to determine release of a therapeutic agent through the porous structure, such that targeted amounts of therapeutic agent can be released for extended times and such that therapeutic device reservoir volume and porous frit structure can be tuned to release the therapeutic agent for an extended time above a target amount for the extended time.

摘要翻译： 本文公开了改进的治疗装置和方法以及用于治疗装置的改进的多孔结构和测量装置。 在许多实施例中，基于气体通过多孔结构的扩散来测量多孔结构。 气体测量可以包括测量的气体量以确定多孔结构对扩散的阻力。 气体通过多孔结构的扩散可以用于确定治疗剂通过多孔结构的释放，使得目标量的治疗剂可以释放延长的时间，并且使得治疗剂储存体积和多孔玻璃料结构可以是 调整为在长时间内将治疗剂释放超过目标量的延长时间。

公开(公告)号：US20130274692A1

公开(公告)日：2013-10-17

申请号：US13814470

申请日：2011-08-04

申请人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

发明人： Yair Alster ,  Eugene De Juan, JR. ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Signe Erickson

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K31/00 ,  A61K31/573 ,  A61K31/58

摘要： A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side.

摘要翻译： 治疗装置可以被配置为将储存器基本上放置在结膜和巩膜之间，使得储存器的尺寸可以增加并且巩膜穿透的尺寸减小以降低侵入性。 该装置可以包括基本上恒定的储存器体积和药物释放机构，其中储存器和机构的体积被调谐以接收一定量的具有注射制剂体积的治疗剂，并释放治疗剂延长的时间 费率简介。 多孔结构可以包括联接到储存器的第一侧和耦合到患者以释放治疗剂的第二侧，并且多个互连通道可以从第一侧延伸到第二侧。

公开(公告)号：US08277830B2

公开(公告)日：2012-10-02

申请号：US13252998

申请日：2011-10-04

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Douglas Sutton

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Douglas Sutton

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

公开(公告)号：US08623395B2

公开(公告)日：2014-01-07

申请号：US13204638

申请日：2011-08-05

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： A61F9/0017 ,  A61K9/0051 ,  A61K38/179 ,  A61K39/395 ,  A61K45/06 ,  A61M37/00 ,  C07K16/22 ,  C07K2317/94 ,  A61K2300/00

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。

公开(公告)号：US20130324918A1

公开(公告)日：2013-12-05

申请号：US13814461

申请日：2011-08-05

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Darren Doud ,  Signe Erickson ,  Mike Barrett ,  David Batten ,  Christina Skieller ,  Greg Stine

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  K. Angela MacFarlane ,  Cary J. Reich ,  Randolph E. Campbell ,  Darren Doud ,  Signe Erickson ,  Mike Barrett ,  David Batten ,  Christina Skieller ,  Greg Stine

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61F9/0008 ,  A61M5/14276 ,  A61M5/178 ,  A61M5/31 ,  A61M5/32 ,  A61M5/46 ,  A61M39/0208 ,  A61M39/0247 ,  A61M2039/027 ,  A61M2039/0276

摘要： Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

摘要翻译： 方法和装置为植入体内的装置提供治疗性液体，例如植入患者眼中的装置的容器。 所述方法和装置可包括注射器以增加注入植入眼中的装置中的治疗剂的量，或用于接收植入眼睛内的装置中的治疗流体的结构或其组合。 植入眼睛中的装置可以包括具有密度不同于治疗流体的流体的储存室，并且该装置可以适于至少部分地将植入的装置流体与储存室内的治疗流体分开以增加和量 治疗液放置在储存室中。