公开(公告)号：US12076193B2

公开(公告)日：2024-09-03

申请号：US18337270

申请日：2023-06-19

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Anshuman Bhuyan ,  Jung Woo Choe ,  Amin Nikoozadeh ,  Butrus T. Khuri-Yakub

IPC: A61B8/00 ,  A61N7/00 ,  A61N7/02 ,  B06B1/02

CPC classification number: A61B8/54 ,  A61B8/4483 ,  A61N7/00 ,  A61N7/02 ,  B06B1/0215 ,  B06B1/0292 ,  A61N2007/0021 ,  A61N2007/0052 ,  B06B2201/76

Abstract: Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

公开(公告)号：US11918832B2

公开(公告)日：2024-03-05

申请号：US16607509

申请日：2018-05-22

Applicant: INSIGHTEC, LTD.

Inventor： Yoav Levy ,  Eyal Zadicario ,  Javier Grinfeld ,  Rafi De Picciotto

IPC: A61N7/00 ,  A61B90/00

CPC classification number: A61N7/00 ,  A61B90/37 ,  A61B2090/374 ,  A61N2007/0021 ,  A61N2007/0039 ,  A61N2007/0065

Abstract: Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.

公开(公告)号：US20230398380A1

公开(公告)日：2023-12-14

申请号：US18029247

申请日：2021-10-08

Applicant: Vanderbilt University

Inventor： Charles F. Caskey ,  Limin Chen ,  William A. Grissom ,  Peter E. Konrad ,  Benoit M. Dawant ,  Willliam J. Rodriguez

IPC: A61N7/02 ,  A61B90/14 ,  A61B90/11

CPC classification number: A61N7/02 ,  A61B90/14 ,  A61B90/11 ,  A61N2007/0021

Abstract: A workflow has been developed that enables initially mapping of a focused ultrasound (FUS) beam using magnetic resonance (MR) thermometry or MR-acoustic radiation force imaging (MR-ARFI) while working within the MRI device. During this procedure, key measurements will be taken including the precise location of the transducer relative to the skull and the transducer parameters (such as amplitudes and phases) required to place the ultrasound focus at the desired focal size and location in the skull. The anatomical measurements will be used to build a patient-specific, device-specific stereotactic frame to hold the transducer in the position relative to the skull and the aberration corrects will be applied. FUS therapy can then be delivered to the patient outside of the MR environment.

公开(公告)号：US11793490B2

公开(公告)日：2023-10-24

申请号：US17367745

申请日：2021-07-06

Applicant: SUNNYBROOK RESEARCH INSTITUTE

Inventor： Kullervo Hynynen ,  Alec Hughes ,  Lulu Deng ,  Meaghan O'Reilly

IPC: A61N7/00 ,  A61B8/00 ,  A61B34/10 ,  A61B90/50 ,  A61B8/08 ,  A61N7/02

CPC classification number: A61B8/4494 ,  A61B8/0808 ,  A61B8/4477 ,  A61B8/5207 ,  A61B34/10 ,  A61B90/50 ,  A61N7/00 ,  A61B8/54 ,  A61B2034/108 ,  A61B2090/502 ,  A61N2007/0021 ,  A61N2007/0052 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0095 ,  A61N2007/027

Abstract: Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.

公开(公告)号：US11730960B2

公开(公告)日：2023-08-22

申请号：US17332934

申请日：2021-05-27

Applicant: Attune Neurosciences, Inc.

Inventor： Keith R. Murphy ,  Pablo Villoslada ,  Rajiv Mahadevan

IPC: A61N1/36 ,  G06N20/00 ,  A61N1/04 ,  A61N7/00

CPC classification number: A61N1/36031 ,  A61N1/0484 ,  G06N20/00 ,  A61N2007/0021

Abstract: The present specification discloses a neuromodulation system comprising a transcranially mounted neuromodulation device and a stimulation control computing environment. The disclosed neuromodulation device comprising at least one ultrasound transducer and at least one EEG electrode and the disclosed stimulation control computing environment comprises a stimulation control unit and offline computing device, the disclosed stimulation control unit including associated systems and methods for controlling the neuromodulation device functionality using acoustic simulations performed on brain image data as well as methods and uses of such neuromodulation systems in modulating brain activity using focused ultrasound stimulation of the thalamus and thalamic sub regions during certain phases of slow wave brain oscillations in order to treat various neural-based disorders or conditions including sleep disorders.

公开(公告)号：US11712226B2

公开(公告)日：2023-08-01

申请号：US17410364

申请日：2021-08-24

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Anshuman Bhuyan ,  Jung Woo Choe ,  Amin Nikoozadeh ,  Butrus T. Khuri-Yakub

IPC: A61B8/00 ,  A61N7/00 ,  B06B1/02 ,  A61N7/02

CPC classification number: A61B8/54 ,  A61B8/4483 ,  A61N7/00 ,  A61N7/02 ,  B06B1/0215 ,  B06B1/0292 ,  A61N2007/0021 ,  A61N2007/0052 ,  B06B2201/76

Abstract: Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

公开(公告)号：US20190239957A1

公开(公告)日：2019-08-08

申请号：US16382889

申请日：2019-04-12

Applicant: National University of Ireland, Galway

Inventor： David Townley ,  Brian Shields ,  Ivan Keogh ,  Michele Qi Zhan ,  Conor Farrel

IPC: A61B18/24 ,  A61N1/36 ,  A61B18/14 ,  A61N1/05 ,  A61F7/12 ,  A61B17/00 ,  A61N1/40 ,  A61N1/32 ,  A61N7/00 ,  A61N1/18

CPC classification number: A61B18/24 ,  A61B17/00234 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/003 ,  A61B2018/00029 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00327 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00797 ,  A61B2018/1467 ,  A61B2218/002 ,  A61F7/123 ,  A61F2007/0006 ,  A61F2007/0054 ,  A61N1/0546 ,  A61N1/18 ,  A61N1/32 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/40 ,  A61N5/022 ,  A61N7/00 ,  A61N2007/0021

Abstract: Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

公开(公告)号：US20190216899A1

公开(公告)日：2019-07-18

申请号：US16275120

申请日：2019-02-13

Applicant: Tulavi Therapeutics, Inc.

Inventor： Corinne Bright

IPC: A61K38/21 ,  A61N5/02 ,  A61K9/06 ,  A61B18/18 ,  A61K31/4422 ,  A61K31/475 ,  A61K31/55 ,  A61B17/34 ,  A61K47/10 ,  A61K45/06 ,  A61B18/14 ,  A61L31/14 ,  A61L31/06 ,  A61L27/56 ,  A61L27/52 ,  A61L27/18 ,  A61B8/12 ,  A61N7/02 ,  A61K31/337 ,  A61K31/19 ,  A61K31/045 ,  A61K9/51 ,  A61K47/36 ,  A61B90/30

CPC classification number: A61K38/217 ,  A61B8/0808 ,  A61B8/12 ,  A61B17/3401 ,  A61B17/3403 ,  A61B18/1492 ,  A61B18/1815 ,  A61B90/30 ,  A61B2017/3413 ,  A61B2018/00434 ,  A61B2018/0044 ,  A61B2018/1861 ,  A61B2018/1869 ,  A61K9/06 ,  A61K9/5161 ,  A61K31/045 ,  A61K31/19 ,  A61K31/337 ,  A61K31/4422 ,  A61K31/475 ,  A61K31/55 ,  A61K45/06 ,  A61K47/10 ,  A61K47/36 ,  A61L27/18 ,  A61L27/52 ,  A61L27/56 ,  A61L31/06 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/06 ,  A61N5/022 ,  A61N7/022 ,  A61N2007/0021 ,  C08L71/02

Abstract: Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4/5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.

公开(公告)号：US20190118003A1

公开(公告)日：2019-04-25

申请号：US16161021

申请日：2018-10-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B18/04 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/003 ,  A61N2007/0056 ,  A61N2007/0078

Abstract: An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

公开(公告)号：US20180229033A1

公开(公告)日：2018-08-16

申请号：US15946919

申请日：2018-04-06

Applicant: Medtronic Ardian Luxembourg S.a.r.l.

Inventor： Mark E. Deem ,  Hanson Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61N1/36 ,  A61N1/20 ,  A61N1/18 ,  A61B18/00

CPC classification number: A61N1/36007 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/0412 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/326 ,  A61N1/327 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.