公开(公告)号：US11730960B2

公开(公告)日：2023-08-22

申请号：US17332934

申请日：2021-05-27

Applicant: Attune Neurosciences, Inc.

Inventor： Keith R. Murphy ,  Pablo Villoslada ,  Rajiv Mahadevan

IPC: A61N1/36 ,  G06N20/00 ,  A61N1/04 ,  A61N7/00

CPC classification number: A61N1/36031 ,  A61N1/0484 ,  G06N20/00 ,  A61N2007/0021

Abstract: The present specification discloses a neuromodulation system comprising a transcranially mounted neuromodulation device and a stimulation control computing environment. The disclosed neuromodulation device comprising at least one ultrasound transducer and at least one EEG electrode and the disclosed stimulation control computing environment comprises a stimulation control unit and offline computing device, the disclosed stimulation control unit including associated systems and methods for controlling the neuromodulation device functionality using acoustic simulations performed on brain image data as well as methods and uses of such neuromodulation systems in modulating brain activity using focused ultrasound stimulation of the thalamus and thalamic sub regions during certain phases of slow wave brain oscillations in order to treat various neural-based disorders or conditions including sleep disorders.

公开(公告)号：US20230390556A1

公开(公告)日：2023-12-07

申请号：US18219037

申请日：2023-07-06

Applicant: ATTUNE NEUROSCIENCES, INC.

Inventor： Keith R. Murphy ,  Pablo Villoslada ,  Rajiv Mahadevan

IPC: A61N1/36 ,  G06N20/00 ,  A61N1/04

CPC classification number: A61N1/36031 ,  G06N20/00 ,  A61N1/0484 ,  A61N2007/0021

Abstract: The present specification discloses a neuromodulation system comprising a transcranially mounted neuromodulation device and a stimulation control computing environment. The disclosed neuromodulation device comprising at least one ultrasound transducer and at least one EEG electrode and the disclosed stimulation control computing environment comprises a stimulation control unit and offline computing device, the disclosed stimulation control unit including associated systems and methods for controlling the neuromodulation device functionality using acoustic simulations performed on brain image data as well as methods and uses of such neuromodulation systems in modulating brain activity using focused ultrasound stimulation of the thalamus and thalamic sub regions during certain phases of slow wave brain oscillations in order to treat various neural-based disorders or conditions including sleep disorders.

公开(公告)号：US20230166129A1

公开(公告)日：2023-06-01

申请号：US18071472

申请日：2022-11-29

Applicant: Attune Neurosciences, Inc.

Inventor： Keith R. Murphy ,  Cameron Good ,  Tommaso Di Ianni ,  Rajiv Mahadevan ,  Pablo Villoslada ,  Michael W. Metz ,  Laura Ott ,  Corey Brown ,  Julia Hines ,  Ayan Bhandari

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0026 ,  A61N2007/0034

Abstract: A head-wearable device is configured to hold at least one ultrasound transducer such that it is properly positioned for brain stimulation. Such a head-wearable device can help to ensure that the transducer makes sufficient contact with the user's head to allow for efficient ultrasound coupling. Each device may also ensure that the ultrasound transducer maintains the same orientation and position relative to the head across successive donning and doffing of the device.

公开(公告)号：US20210370064A1

公开(公告)日：2021-12-02

申请号：US17332934

申请日：2021-05-27

Applicant: Attune Neurosciences, Inc.

Inventor： Keith R. Murphy ,  Pablo Villoslada ,  Rajiv Mahadevan

IPC: A61N1/36 ,  A61N1/04 ,  G06N20/00

Abstract: The present specification discloses a neuromodulation system comprising a transcranially mounted neuromodulation device and a stimulation control computing environment. The disclosed neuromodulation device comprising at least one ultrasound transducer and at least one EEG electrode and the disclosed stimulation control computing environment comprises a stimulation control unit and offline computing device, the disclosed stimulation control unit including associated systems and methods for controlling the neuromodulation device functionality using acoustic simulations performed on brain image data as well as methods and uses of such neuromodulation systems in modulating brain activity using focused ultrasound stimulation of the thalamus and thalamic sub regions during certain phases of slow wave brain oscillations in order to treat various neural-based disorders or conditions including sleep disorders.