公开(公告)号：US09943077B2

公开(公告)日：2018-04-17

申请号：US15195454

申请日：2016-06-28

申请人： Fenwal, Inc.

发明人： Kyungyoon Min ,  Katherine Radwanski

IPC分类号： A01N1/02 ,  A61M1/36 ,  B01D61/28 ,  B01D61/32 ,  A61M1/02 ,  A61M1/30

CPC分类号： A01N1/0226 ,  A01N1/0273 ,  A61M1/0209 ,  A61M1/0236 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0429 ,  B01D61/28 ,  B01D61/32

摘要： Methods and systems for processing and conditioning red blood cells are disclosed. The methods and systems may be used to make a readily transfusible red blood cell product with reduced plasma. In general, the plasma content of the supernatant of the red blood cell product is no greater than about 15%. The red blood cell products are prepared using the disclosed methods and systems remain transfusible for up to 42 days.

公开(公告)号：US20170348471A1

公开(公告)日：2017-12-07

申请号：US15686289

申请日：2017-08-25

申请人： Nikkiso Company Limited

发明人： Hitoshi Goto ,  Masahiro Toyoda ,  Tomoya Murakami ,  Shigeaki Funamura

IPC分类号： A61M1/30 ,  A61M1/36 ,  A61B5/0408 ,  A61M5/50

摘要： A medical apparatus in which the measurement of an electrocardiogram and the detection of blood leakage that may occur if an accessing unit comes off the patient can be performed accurately without fail, and with which the efficiency in the operation to be performed before the treatment can be improved. A medical apparatus includes a blood purification device including an accessing unit formed of a venous puncture needle stickable into a patient, electrocardiogram-measuring devices closely attached to a skin of the patient and being capable of measuring an electrocardiogram of the patient, and a blood-leakage-detecting device attached to a position near the accessing unit and being capable of detecting blood of the patient that may leak from the accessing unit. The medical apparatus further includes an integrated detecting device provided as a unit including the electrocardiogram-measuring device and the blood-leakage-detecting device.

公开(公告)号：US09821104B2

公开(公告)日：2017-11-21

申请号：US14167117

申请日：2014-01-29

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Christoph Bocklet

IPC分类号： A61M37/00 ,  A61M1/30

CPC分类号： A61M1/306 ,  A61M1/30 ,  A61M1/303 ,  A61M2202/0413

摘要： An extracorporeal blood treatment device for operation with a single patient connection, connected by an arterial and a venous blood line to an extracorporeal blood circuit, and a method for operating a blood treatment device with a single patient connection. The blood treatment device has two apparatuses for conveying blood in the arterial and venous blood lines. The second apparatus for conveying blood comprises means for collecting blood and means for establishing a pressure in the means for collecting blood, so that blood collected in the means for collecting blood flows to the patient connection. Furthermore, the blood treatment device has arterial and venous closure elements for interrupting the flow of liquid in the arterial and venous blood lines, as well as a control unit for actuating the two apparatuses for conveying blood and the arterial and venous closure elements. The blood treatment device and the method for operating are characterized in that the first apparatus for conveying blood is operated both during the arterial and venous phases, so that blood flows continuously through the blood treatment unit.

公开(公告)号：US20170252499A2

公开(公告)日：2017-09-07

申请号：US14167117

申请日：2014-01-29

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Christoph Bocklet

IPC分类号： A61M1/30

CPC分类号： A61M1/306 ,  A61M1/30 ,  A61M1/303 ,  A61M2202/0413

摘要： An extracorporeal blood treatment device for operation with a single patient connection, connected by an arterial and a venous blood line to an extracorporeal blood circuit, and a method for operating a blood treatment device with a single patient connection. The blood treatment device has two apparatuses for conveying blood in the arterial and venous blood lines. The second apparatus for conveying blood comprises means for collecting blood and means for establishing a pressure in the means for collecting blood, so that blood collected in the means for collecting blood flows to the patient connection. Furthermore, the blood treatment device has arterial and venous closure elements for interrupting the flow of liquid in the arterial and venous blood lines, as well as a control unit for actuating the two apparatuses for conveying blood and the arterial and venous closure elements. The blood treatment device and the method for operating are characterized in that the first apparatus for conveying blood is operated both during the arterial and venous phases, so that blood flows continuously through the blood treatment unit.

公开(公告)号：US20170173251A1

公开(公告)日：2017-06-22

申请号：US15387053

申请日：2016-12-21

申请人： Fresenius Medical Care Holdings, Inc.

发明人： Matthew Doyle ,  Lee Tanenbaum ,  Donovan Halliburton ,  Eric Hoffstetter

IPC分类号： A61M1/36 ,  A61M1/30 ,  G06F19/00 ,  A61M1/26 ,  A61M39/10 ,  A61M1/34 ,  A61M1/16

摘要： A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient.

公开(公告)号：US20170143886A1

公开(公告)日：2017-05-25

申请号：US15423717

申请日：2017-02-03

申请人： DEKA Products Limited Partnership

发明人： MICHAEL J. WILT ,  DIRK A. VAN DER MERWE ,  TODD A. BALLANTYNE ,  KEVIN L. GRANT ,  JONATHAN P. ROSSE ,  CATHARINE N. FLYNN ,  BRIAN K. YEE

IPC分类号： A61M1/16 ,  A61K33/00 ,  A61M1/36 ,  A61M1/30 ,  A61M1/34 ,  A61M1/26

CPC分类号： A61M1/1601 ,  A61K33/00 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1062 ,  A61M1/1087 ,  A61M1/1096 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/1619 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1692 ,  A61M1/267 ,  A61M1/301 ,  A61M1/34 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/3627 ,  A61M1/3638 ,  A61M1/3672 ,  A61M5/172 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65 ,  G06F19/3481 ,  Y02A50/395 ,  Y02A90/26

摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

公开(公告)号：US09610394B2

公开(公告)日：2017-04-04

申请号：US14368867

申请日：2012-12-27

申请人： GAMBRO LUNDIA AB

发明人： Rocco Cappella ,  Mirco Lancellotti

IPC分类号： A61M1/36 ,  A61M1/30 ,  A61M1/14

CPC分类号： A61M1/3653 ,  A61M1/14 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/3621 ,  A61M1/3624 ,  A61M1/3639 ,  A61M1/3656 ,  A61M2205/50

摘要： An apparatus is described for extracorporeal blood treatment comprising an extracorporeal circuit (2), a first pump (13) operating at the removal line (3) of the blood, a second pump (14) operating at the return line (7) of the blood to the patient, a first blood reservoir (21) operating on the blood return line (7) upstream of the second blood pump (14) and a sensor (22) predisposed to detect at least a parameter, for example the pressure in the first reservoir; a control unit (100) connected to the first pump (13), to the second pump (14) and to the sensor (22) is configured such as to control the first pump (13) to promote removal of the blood along the removal line and the movement of the second pump (14) to promote the return of the blood to the patient along the return line, the control of the second pump being carried out on the basis of the signal emitted by the sensor acting on the first reservoir.

公开(公告)号：US09572920B2

公开(公告)日：2017-02-21

申请号：US14129097

申请日：2012-06-18

申请人： Olof Jansson ,  Mattias Holmer ,  Eddie Nilsson ,  Lennart Jonsson

发明人： Olof Jansson ,  Mattias Holmer ,  Eddie Nilsson ,  Lennart Jonsson

IPC分类号： A61M1/36 ,  A61M1/30

CPC分类号： A61M1/367 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3621 ,  A61M2205/125 ,  A61M2205/128 ,  Y10T137/0318 ,  Y10T137/85986 ,  Y10T137/86035

摘要： A disposable for use in blood treatment including a blood treatment unit and two membrane pumps connected in parallel on one side of the blood treatment unit. The disposable is operable in a single-needle mode, in which the pumps generate a pulsatile flow of blood through the blood treatment unit, and in a double-needle mode, in which the pumps generate an essentially continuous flow of blood through the blood treatment unit. The pumps connect to a supply of treatment fluid such that alternating flows of treatment fluid causes the pumps to generate the desired flows of blood in the single-needle and double-needle modes. The treatment fluid may be used as motive fluid for displacing the blood in the membrane pumps and/or as control fluid for controlling opening and/or closing of upstream and downstream commutation valves in the membrane pumps.

摘要翻译： 一次性用于血液处理，包括血液处理单元和两个血液处理单元一侧并联连接的膜泵。 一次性可以单针模式操作，其中泵通过血液处理单元产生脉动血液流，并且在双针模式中，其中泵通过血液处理产生基本上连续的血液流 单元。 泵连接到供应的处理流体，使得处理流体的交替流使得泵以单针和双针模式产生期望的血液流。 处理流体可以用作用于移动膜泵中的血液的运动流体和/或用作控制膜泵中的上游和下游换向阀的打开和/或关闭的控制流体。

公开(公告)号：US09562529B2

公开(公告)日：2017-02-07

申请号：US13933532

申请日：2013-07-02

申请人： B. Braun Avitum AG

发明人： Oliver Schaefer

IPC分类号： F04B43/12 ,  F04B45/06 ,  F04B43/08 ,  F04D29/20 ,  F04D29/26 ,  A61M1/30

CPC分类号： F04B43/12 ,  A61M1/30 ,  A61M5/14232 ,  F04B43/08 ,  F04B43/1253 ,  F04B45/06 ,  F04D29/20 ,  F04D29/266

摘要： Tube roller pumps for blood treatment devices are disclosed. The pumps include a curved surface with a rotor rotatable therein. The rotor attaches via a shaft reception to a drive shaft of the pump. The rotor has a first locking element for axially locking the rotor on the shaft and a second locking element for rotationally coupling the shaft and the rotor. The shaft reception and the drive shaft guide the rotor to a position on the shaft, when pushed onto the shaft, and, at this position, the first element may be moved by the shaft from locked to released. The rotor, when pushed further onto the shaft, is moved to another position at which the first element is automatically moved back to locked and the second element may be brought into manual engagement with the shaft to transmit torque from the shaft to the rotor.

摘要翻译： 公开了用于血液处理装置的管式滚子泵。 泵包括具有可转动的转子的曲面。 转子通过轴接收附接到泵的驱动轴。 转子具有用于将转子轴向地锁定在轴上的第一锁定元件和用于旋转地联接轴和转子的第二锁定元件。 轴接收和驱动轴将转子引导到轴上的位置，当被推到轴上时，并且在该位置处，第一元件可以被轴移动以锁定到释放。 当转子进一步推动到轴上时，该转子被移动到另一个位置，在该位置处第一元件被自动地移回到锁定位置，并且第二元件可以与轴进行手动接合，以将转矩从轴传递到转子。

公开(公告)号：US09498567B2

公开(公告)日：2016-11-22

申请号：US14500166

申请日：2014-09-29

申请人： FENWAL, INC.

发明人： Amit J. Patel ,  Samantha M. Planas

IPC分类号： A61M1/38 ,  A61M1/02 ,  A61M1/36 ,  A61M1/30 ,  A61M1/34 ,  A61M1/26

CPC分类号： A61M1/382 ,  A61M1/0231 ,  A61M1/029 ,  A61M1/262 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/305 ,  A61M1/308 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3496 ,  A61M1/3626 ,  A61M1/3646 ,  A61M1/3693 ,  A61M1/38 ,  A61M2205/18 ,  A61M2205/3375 ,  A61M2205/3393

摘要： A method is provided for controlling the return phase of a blood separation procedure having a draw phase in which blood is drawn through an access or donor line, is separated, and a fluid, such as a cellular concentrate, is flowed into a reservoir, and a return phase in which fluid is flowed from the reservoir through the donor line. The method comprises flowing fluid from the reservoir through the donor line in a steady state return; monitoring the donor line for the presence of air; and, upon detecting air in the donor line, determining the amount of fluid remaining in the reservoir. Then, either i) the donor line is purged, if the amount of fluid remaining in the reservoir exceeds a predetermined amount, and the steady state return of fluid from the reservoir through the donor line is resumed; or ii) if the amount of fluid remaining in the reservoir does not exceed the predetermined amount, the return phase is ended by terminating the flow of fluid from the reservoir through the donor line.

摘要翻译： 提供了一种方法，用于控制血液分离程序的返回阶段，该血液分离程序具有抽吸阶段，在该阶段，血液通过进入或供体管线被抽取，被分离，并且诸如细胞浓缩物的流体流入储存器，以及 流体从储存器通过供体管线流动的返回阶段。 该方法包括使流体从稳定状态返回中流过供体管; 监测供体线是否存在空气; 并且在检测供体管线中的空气时，确定储存器中剩余的流体的量。 然后，i）如果储存器中残留的流体的量超过预定量，并恢复流体从储存器通过供体管线的稳定状态，则排出供体管线; 或ii）如果储存器中剩余的流体量不超过预定量，则通过终止来自储存器的流体通过供体管线的流动来终止返回阶段。