公开(公告)号：US10053504B2

公开(公告)日：2018-08-21

申请号：US15132647

申请日：2016-04-19

Applicant: Abraxis BioScience, LLC

Inventor： Vuong Trieu

IPC: A61K39/00 ,  C07K16/18 ,  C07K14/51 ,  A61K39/44 ,  A61K49/00 ,  C12N9/96 ,  G01N33/53 ,  C07K14/78 ,  C07K14/705 ,  A61K47/68 ,  A61K39/395 ,  A61K38/00

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K39/44 ,  A61K47/50 ,  A61K47/62 ,  A61K47/64 ,  A61K47/6835 ,  A61K47/6851 ,  A61K49/0002 ,  A61K49/0056 ,  A61K2039/505 ,  C07K14/51 ,  C07K14/70521 ,  C07K14/78 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/96 ,  G01N33/53

Abstract: The invention provides compositions comprising SPARC binding ScFv and its use.

公开(公告)号：US20180221515A1

公开(公告)日：2018-08-09

申请号：US15880481

申请日：2018-01-25

Applicant: The University of North Carolina at Chapel Hill ,  The Arizona Board of Regents on behalf of The University of Arizona ,  The Regents of the University of Colorado, a body corporate

Inventor： Paul Alexander Dayton ,  Paul Steven Sheeran ,  Terry Onichi Matsunaga ,  Mark A. Borden

IPC: A61K49/22 ,  B01J13/02 ,  A61K49/00 ,  A61K9/51 ,  A61K47/06 ,  A61K41/00 ,  A61K48/00

CPC classification number: A61K9/51 ,  A61K9/5123 ,  A61K9/5192 ,  A61K41/0028 ,  A61K47/06 ,  A61K48/00 ,  A61K49/0002 ,  A61K49/221 ,  A61K49/223 ,  A61K49/226 ,  B01J13/02

Abstract: Acoustically activatable particles having low vaporization energy and methods for making and using same are disclosed. A particle of material includes a first substance that includes at least one component that is a gas 25° C. and atmospheric pressure. A second substance, different from the first substance, encapsulates the first substance to create a droplet or emulsion that is stable at room temperature and atmospheric pressure. At least some of the first substance exists in a gaseous phase at the time of encapsulation of the first substance within the second substance to form a bubble. After formation of the bubble, the bubble is condensed into a liquid phase, which causes the bubble to transform into the droplet or emulsion having a core consisting of a liquid. The droplet or emulsion is an activatable phase change agent that remains a droplet having a core consisting of a liquid at 25° C. and atmospheric pressure. The first substance has a boiling point below 25° C. at atmospheric pressure.

公开(公告)号：US20180207096A1

公开(公告)日：2018-07-26

申请号：US15746357

申请日：2016-07-22

Applicant: Luxembourg Institute Of Science And Technology (LIST)

Inventor： Gaelle Corne ,  Damien Lenoble ,  Jean-Sebastien Thomann

IPC: A61K9/127 ,  A61K8/14 ,  A61Q19/00 ,  A61K49/00 ,  A61K9/51

CPC classification number: A61K9/1271 ,  A61K8/14 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/5115 ,  A61K49/0002 ,  A61Q19/00

Abstract: A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

公开(公告)号：US20180164217A1

公开(公告)日：2018-06-14

申请号：US15835582

申请日：2017-12-08

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Cristina Zavaleta ,  Michael J. Mandella ,  Zhen Qiu

IPC: G01N21/65 ,  A61B5/00 ,  A61B5/15 ,  A61K49/00

CPC classification number: G01N21/65 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1072 ,  A61B5/150832 ,  A61B2562/0257 ,  A61K49/0002 ,  G01N21/6456 ,  G01N21/658 ,  G01N2021/6439 ,  G01N2021/656

Abstract: The present disclosure describes a Raman topography system, which includes a container with at least one Raman probe positioned within. Also described are methods of imaging which include the Raman topography system.

公开(公告)号：US20180161461A1

公开(公告)日：2018-06-14

申请号：US15877042

申请日：2018-01-22

Applicant: Ecole Polytechnique

Inventor： Markus Schoeffel ,  Antigoni Alexandrou ,  Cedric Bouzigues ,  Thierry Gacoin ,  Jean-Pierre Boilot

IPC: A61K49/18 ,  A61K49/00

CPC classification number: A61K49/1824 ,  A61K49/0002 ,  B82Y5/00 ,  B82Y15/00 ,  C09K11/7794

Abstract: The present application concerns multimodal composite products for imaging, in particular for diagnostic imaging, and optionally for therapy, in particular composite products which are capable of being used as contrast agents, in particular in magnetic resonance imaging (MRI), and/or in imaging techniques such as, for example, in optical imaging, in the optical detection of oxidants, in positron emission tomography (PET), in tomodensitometry (TDM) and/or in ultrasound imaging, and optionally simultaneously for use in therapy. These products are based on a particle comprising or consisting of a portion provided with a contrast agent activity and/or a paramagnetic activity, and a portion provided with a luminescent activity and optionally an oxidant detection activity.

公开(公告)号：US20180154024A1

公开(公告)日：2018-06-07

申请号：US15872763

申请日：2018-01-16

Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada,

Inventor： Xiaoshan Zhu ,  Violeta Demillo

IPC: A61K49/00 ,  A61K49/18 ,  G01N33/58 ,  A61K9/48

CPC classification number: A61K49/0067 ,  A61K9/48 ,  A61K49/0002 ,  A61K49/0056 ,  A61K49/1866 ,  A61K49/1887 ,  B82Y5/00 ,  G01N33/587 ,  G01N33/588

Abstract: Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro. The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation. The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof. Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites.

公开(公告)号：US09987380B2

公开(公告)日：2018-06-05

申请号：US13549309

申请日：2012-07-13

Applicant: Zibo Li ,  Francois P. Gabbai ,  Peter S. Conti ,  Todd W. Hudnall ,  Tzu-Pin Lin ,  Shuanglong Liu ,  Chiun-Wei Huang

Inventor： Zibo Li ,  Francois P. Gabbai ,  Peter S. Conti ,  Todd W. Hudnall ,  Tzu-Pin Lin ,  Shuanglong Liu ,  Chiun-Wei Huang

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  A61K49/00 ,  C07F5/02

CPC classification number: A61K51/0446 ,  A61K49/0002 ,  A61K49/0021 ,  A61K51/00 ,  A61K51/0423 ,  A61K51/0455 ,  C07F5/022

Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.

公开(公告)号：US09981047B2

公开(公告)日：2018-05-29

申请号：US14912997

申请日：2014-08-19

Applicant: Seyed Moien Moghimi ,  Linping Wu ,  Davoud Ahmadvand ,  Ladan Parhamifarr ,  Thomas Lars Andresen

Inventor： Seyed Moien Moghimi ,  Linping Wu ,  Davoud Ahmadvand ,  Ladan Parhamifarr

IPC: A61K47/69 ,  A61K47/66 ,  A61K49/00 ,  A61K47/64

CPC classification number: A61K47/66 ,  A61K47/64 ,  A61K47/69 ,  A61K47/6901 ,  A61K47/6911 ,  A61K47/6929 ,  A61K47/6953 ,  A61K49/0002 ,  A61K49/0056

Abstract: A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (TFRC) and/or receptor for advanced glycation end products (RAGE). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system.

公开(公告)号：US20180133363A1

公开(公告)日：2018-05-17

申请号：US15653966

申请日：2017-07-19

Applicant: Endomedix, Inc.

Inventor： Weiliam Chen ,  John M. Abrahams

IPC: A61L26/00 ,  C08L89/00 ,  C08L5/08 ,  A61K31/721 ,  A61K31/722 ,  A61L24/10 ,  A61L24/08 ,  A61L24/04 ,  A61L24/00 ,  A61K51/12 ,  A61K49/04 ,  A61K49/00 ,  A61K48/00 ,  A61K38/18 ,  A61K9/00 ,  A61K9/06

CPC classification number: A61L26/0052 ,  A61K9/0085 ,  A61K9/06 ,  A61K31/721 ,  A61K31/722 ,  A61K38/1875 ,  A61K47/60 ,  A61K47/6903 ,  A61K48/00 ,  A61K49/0002 ,  A61K49/0457 ,  A61K51/1213 ,  A61L24/0031 ,  A61L24/043 ,  A61L24/08 ,  A61L24/104 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L2300/232 ,  A61L2300/236 ,  C08L89/00 ,  C08L5/08

Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

公开(公告)号：US09950002B2

公开(公告)日：2018-04-24

申请号：US14487928

申请日：2014-09-16

Applicant: Regents of the University of Minnesota

Inventor： Karunya K. Kandimalla

IPC: A61K51/12 ,  A61K31/726 ,  A61K49/18 ,  A61K49/00 ,  A61K9/51 ,  A61K9/00

CPC classification number: A61K31/726 ,  A61K9/0019 ,  A61K9/5161 ,  A61K49/0002 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/1863 ,  A61K51/1244

Abstract: A nanotheranostic probe and its use to facilitate diagnoses, treatment and targeting of amyloid deposits are disclosed herein.