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1.发明申请METHODS AND COMPOSITIONS FOR POSITRON EMISSION TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING 有权立体声发射计算机心肌灌注成像的方法和组成公开(公告)号：US20150132222A1
公开(公告)日：2015-05-14
申请号：US14401470
申请日：2013-03-15
Applicant: Peter S. Conti , Shuanglong Liu , Zibo Li
Inventor： Peter S. Conti , Shuanglong Liu , Zibo Li
CPC classification number: A61K51/044 , A61B6/037 , A61B6/503 , A61K49/04 , A61K51/0482 , A61K51/0497 , A61K51/088
Abstract: This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.
Abstract translation: 本发明提供用作正电子发射断层摄影心肌灌注成像（PET MPI）的成像示踪剂的化合物和组合物。 根据本发明实施方案的化合物通常包含三个结构元件：i）三苯基鏻部分; ii）螯合元素; 和iii）疏水性元件。 示踪剂化合物优选用64Cu或18F放射标记。 还提供了合成化合物的方法，衍生化合物的方法及其衍生物。
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公开(公告)号：US09987380B2
公开(公告)日：2018-06-05
申请号：US13549309
申请日：2012-07-13
Applicant: Zibo Li , Francois P. Gabbai , Peter S. Conti , Todd W. Hudnall , Tzu-Pin Lin , Shuanglong Liu , Chiun-Wei Huang
Inventor： Zibo Li , Francois P. Gabbai , Peter S. Conti , Todd W. Hudnall , Tzu-Pin Lin , Shuanglong Liu , Chiun-Wei Huang
CPC classification number: A61K51/0446 , A61K49/0002 , A61K49/0021 , A61K51/00 , A61K51/0423 , A61K51/0455 , C07F5/022
Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.
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公开(公告)号：US09789211B2
公开(公告)日：2017-10-17
申请号：US14401470
申请日：2013-03-15
Applicant: Peter S. Conti , Shuanglong Liu , Zibo Li
Inventor： Peter S. Conti , Shuanglong Liu , Zibo Li
CPC classification number: A61K51/044 , A61B6/037 , A61B6/503 , A61K49/04 , A61K51/0482 , A61K51/0497 , A61K51/088
Abstract: This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.
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公开(公告)号：US20120107240A1
公开(公告)日：2012-05-03
申请号：US13373072
申请日：2011-11-03
Applicant: Shuanglong Liu , Hongguang Liu , Zhen Cheng
Inventor： Shuanglong Liu , Hongguang Liu , Zhen Cheng
IPC: A61K51/00 , C07D211/78 , C12Q1/02
CPC classification number: A61K51/0459 , C07D213/81 , G01N33/5011 , G01N33/5088 , G01N33/5743 , G01N33/60 , G01N2800/52
Abstract: Embodiments of the present disclosure provide for labeled probes such as a 3-18F-fluoropicolinamide probe, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events (e.g., malignant melanoma), using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events, using labeled probes, and the like.
Abstract translation: 本公开的实施方案提供了标记的探针，例如3-18F-氟吡啶酰胺探针，制备标记探针的方法，包括标记探针的药物组合物，使用标记探针的方法，诊断，定位，监测和/或评估黑色素的方法 使用标记的探针，用于诊断，定位，监测和/或评估黑色素相关疾病，癌症，肿瘤，癌前期细胞和相关的试剂盒的相关疾病，癌症，肿瘤，癌前期细胞和相关生物学事件（例如，恶性黑素瘤） 生物学事件，使用标记探针等。
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公开(公告)号：US11065349B2
公开(公告)日：2021-07-20
申请号：US14438863
申请日：2013-03-15
Applicant: Peter S. Conti , Zibo Li , Shuanglong Liu , Dan Li
Inventor： Peter S. Conti , Zibo Li , Shuanglong Liu , Dan Li
Abstract: This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.
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6.发明授权Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same 有权笼状双功能螯合剂，铜64放射性药物和使用其的PET成像
公开(公告)号：US09403875B2
公开(公告)日：2016-08-02
申请号：US12695125
申请日：2010-01-27
Applicant: Peter S. Conti , Hancheng Cai , Zibo Li , Shuanglong Liu
Inventor： Peter S. Conti , Hancheng Cai , Zibo Li , Shuanglong Liu
CPC classification number: A61K51/0474 , A61K51/0482 , A61K51/082 , A61K51/088 , A61K51/1093 , C07D487/04 , C07D487/08 , C07K5/1021 , C07K7/086
Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.
Abstract translation: 公开了一类通用的基于Sarcophagine的双功能螯合剂（BFC），其包含用于用具有成像，治疗或对比应用放射性标记的金属进行标记的六氮杂笼，以及一种或多种接头（A）和（B）。 所述化合物具有通式，其中A是选自胺，羧酸，酯，羰基，硫醇，叠氮化物和烯烃的官能团，B是选自以下的官能团： 的氢，胺，羧酸和酯，羰基，硫醇，叠氮化物和烯烃。 还公开了BFC和靶向部分的缀合物，其可以是肽或抗体。 还公开了可用作放射性药物，成像剂或造影剂的BFC /靶向部分缀合物的金属络合物。
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7.发明授权Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis 有权双恶唑烷的合成，结构和用途，用于不对称催化和合成
公开(公告)号：US07763734B2
公开(公告)日：2010-07-27
申请号：US11737371
申请日：2007-04-19
Applicant: Christian Wolf , Shuanglong Liu
Inventor： Christian Wolf , Shuanglong Liu
IPC: C07D263/52 , C07D498/20
CPC classification number: C07D498/10 , C07B2200/07 , C07C29/42 , C07C41/30 , C07C2601/02 , C07C2601/16 , C07C33/30 , C07C33/38 , C07C33/28 , C07C33/486 , C07C43/23
Abstract: One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.
Abstract translation: 本发明的一个方面涉及手性双恶唑烷及其在不对称催化中的用途。 手性双恶唑烷是一类新的化合物，预期可以发现多种应用，例如不对称合成。 例如，双恶唑烷配体能够进行一系列芳族和脂族醛的催化对映选择性炔基化和烷基化，以高产率和对映体过量产生手性炔丙醇和仲醇。
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8.发明申请SYNTHESIS, STRUCTURE AND USE OF BISOXAZOLIDINES FOR ASYMMETRIC CATALYSIS AND SYNTHESIS 有权二异氰酸酯的合成，结构和用途用于不对称催化和合成
公开(公告)号：US20070265255A1
公开(公告)日：2007-11-15
申请号：US11737371
申请日：2007-04-19
Applicant: Christian Wolf , Shuanglong Liu
Inventor： Christian Wolf , Shuanglong Liu
IPC: A61K31/5383 , C07D263/52
CPC classification number: C07D498/10 , C07B2200/07 , C07C29/42 , C07C41/30 , C07C2601/02 , C07C2601/16 , C07C33/30 , C07C33/38 , C07C33/28 , C07C33/486 , C07C43/23
Abstract: One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.
Abstract translation: 本发明的一个方面涉及手性双恶唑烷及其在不对称催化中的用途。 手性双恶唑烷是一类新的化合物，预期可以发现多种应用，例如不对称合成。 例如，双恶唑烷配体能够进行一系列芳族和脂族醛的催化对映选择性炔基化和烷基化，以高产率和对映体过量产生手性炔丙醇和仲醇。
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9.发明申请18F LABELED BODIPY DYE AND ITS DERIVATIVES FOR PET IMAGING OF HEART PERFUSION AND OTHERS 审中-公开18F标签身体染料及其用于PET成像心脏及其他物质的衍生物
公开(公告)号：US20150297760A1
公开(公告)日：2015-10-22
申请号：US14438863
申请日：2013-03-15
Applicant: Peter S. CONTI , Zibo LI , Shuanglong LIU , Dan LI
Inventor： Peter S. CONTI , Zibo LI , Shuanglong LIU , Dan LI
CPC classification number: A61K51/0446 , A61B5/0035 , A61B5/0071 , A61B6/032 , A61B6/037 , A61K49/0002 , A61K49/0021
Abstract: This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.
Abstract translation: 本发明提供了一种能够同时作为荧光成像示踪剂和正电子发射断层成像示踪剂的双模式成像示踪剂。 根据本发明的示踪剂通常具有嵌入其中的氟化硼元件的荧光核心。 示踪剂的示例性实施方案包括18F标记的BODIPY化合物及其衍生物。 还提供了含有放射性标记或预标记状态的BODIPY染料的无菌制剂的示踪试剂盒，以及使用18F标记的双重模式示踪剂对心脏灌注成像的方法。
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10.发明申请Boron-Based Dual Imaging Probes, Compositions and Methods for Rapid Aqueous F-18 Labeling, and Imaging Methods Using Same 有权基于硼的双成像探针，快速水性F-18标记的组合物和方法，以及使用相同的成像方法
公开(公告)号：US20130189185A1
公开(公告)日：2013-07-25
申请号：US13549309
申请日：2012-07-13
Applicant: Zibo LI , Francois P. GABBAI , Peter S. CONTI , Todd W. HUDNALL , Tzu-Pin LIN , Shuanglong LIU , Chiun-Wei HUANG
Inventor： Zibo LI , Francois P. GABBAI , Peter S. CONTI , Todd W. HUDNALL , Tzu-Pin LIN , Shuanglong LIU , Chiun-Wei HUANG
CPC classification number: A61K51/0446 , A61K49/0002 , A61K49/0021 , A61K51/00 , A61K51/0423 , A61K51/0455 , C07F5/022
Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.
Abstract translation: 用作PET和/或荧光成像探针的组合物，式I化合物，包括其盐，水合物和溶剂合物：其中R 1 -R 7可以独立地选自氢，卤素，羟基，烷氧基，硝基，取代和未取代的 氨基，环烷基，羧基，羧酸及其酯，氰基，卤代烷基，芳基，X选自C和N; 并且A选自氢，卤素，羟基，烷氧基，硝基，取代和未取代的氨基，烷基，环烷基，羧基，羧酸及其酯，氰基，卤代烷基，芳基，包括苯基和氨基苯基，以及杂芳基。
