公开(公告)号：US20230406933A1

公开(公告)日：2023-12-21

申请号：US18035070

申请日：2021-11-02

Applicant: Randox Laboratories Ltd.

Inventor： Marshall Dunlop ,  Shirley Schon ,  John Lamont ,  Peter Fitzgerald

IPC: C07K16/28

CPC classification number: C07K16/2827 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/33 ,  C07K2317/22 ,  C07K2317/94 ,  C07K2317/76

Abstract: The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.

公开(公告)号：US11623214B2

公开(公告)日：2023-04-11

申请号：US16772593

申请日：2018-12-07

Applicant: Randox Laboratories Ltd

Inventor： Stuart Jackson

IPC: B01L3/00

Abstract: A fluidic card assembly (1) comprises an inlet (20) for introducing a fluid to the fluidic card assembly (1), a turbulent flow portion (30) downstream of the inlet (20), the turbulent flow portion (30) comprising a widening fluid channel (31) whereby a fluid introduced via the inlet (20) channel undergoes turbulence, and a laminar flow portion (40) downstream of the turbulent flow portion (30). The laminar flow portion (40) is configured to allow fluid passing from the turbulent flow portion (30) into the laminar flow portion (40) to establish a laminar flow pattern, and is configured to house a biochip (44) such that a fluid in the laminar flow portion (40) may be in contact with the biochip (44).

公开(公告)号：US20220412994A1

公开(公告)日：2022-12-29

申请号：US17775217

申请日：2020-11-06

Applicant: Randox Laboratories Ltd

Inventor： Paul Innocenzi ,  Mark Ruddock ,  John Lamont ,  Peter Fitzgerald

IPC: G01N33/68

Abstract: Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.

公开(公告)号：US20220193685A1

公开(公告)日：2022-06-23

申请号：US17602897

申请日：2020-04-08

Applicant: RANDOX LABORATORIES LTD

Inventor： Proinnsias McGleenan ,  P Evans ,  Stuart Jackson ,  Martin Reid ,  Peter Fitzgerald

IPC: B01L9/00

Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.

公开(公告)号：US10751720B2

公开(公告)日：2020-08-25

申请号：US15360038

申请日：2016-11-23

Applicant: Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

Inventor： Gareth Wilson ,  Michael Hooks ,  Peter Fitzgerald ,  John Lamont ,  Ivan McConnell

IPC: B01L9/00 ,  B01L3/00 ,  B65B69/00 ,  G01N1/28 ,  G01N33/50 ,  B65D71/50

Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

公开(公告)号：US10545157B2

公开(公告)日：2020-01-28

申请号：US15026577

申请日：2014-10-06

Applicant: Randox Teoranta

Inventor： Ivan McConnell ,  Ciaran Richardson ,  John Lamont ,  Stephen Peter Fitzgerald

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/68

Abstract: The disclosure provides methods and solid states devices for detecting and staging chronic kidney disease in a patient, where the levels of biomarkers in a sample obtained from a patient are elevated or reduced compared to the levels in a sample obtained from healthy subject. In addition, the disclosure provides the use of methods and solid state devices for measurement of specific biological markers for determining the efficacy of a treatment for chronic kidney disease and for determining a drug treatment protocol for a subject suffering from chronic kidney disease.

公开(公告)号：US10209167B2

公开(公告)日：2019-02-19

申请号：US15036811

申请日：2014-11-13

Applicant: Randox Laboratories Ltd.

Inventor： Michael Veitinger ,  Maria Zellner

IPC: G01N1/40 ,  C12Q1/48 ,  G01N33/68 ,  G01N33/86

Abstract: The present invention provides a novel method of in vitro sample preparation for the analysis of proteins. In a first aspect, the present invention is a method comprising the separation and individual treatment of blood platelets and platelet-poor plasma obtained from a platelet-rich plasma sample. This allows for optimal treatment of both fractions and overcomes many of the problems associated with current methods. In a second aspect of the present invention the platelet sample preparation method can be implemented before a biochip based immunoassay for the detection of platelet proteins in combination with plasma proteins.

公开(公告)号：USD815752S1

公开(公告)日：2018-04-17

申请号：US29510481

申请日：2014-11-28

Applicant: Randox Laboratories Ltd.

Designer： Stuart Jackson ,  Ivan McConnell ,  John Lamont ,  Peter Fitzgerald

公开(公告)号：USD676571S1

公开(公告)日：2013-02-19

申请号：US29398120

申请日：2011-07-26

Applicant: Gareth Wilson

Designer： Gareth Wilson

公开(公告)号：US20100047770A1

公开(公告)日：2010-02-25

申请号：US11576521

申请日：2005-10-06

Applicant: Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

Inventor： Martin Andrew Crockard ,  John Victor Lamont ,  Stephen Peter Fitzgerald

IPC: C12Q1/68 ,  C07K7/08 ,  C07K14/435 ,  C07K16/00 ,  C07H21/04

CPC classification number: G01N33/57415

Abstract: A method for the detection of the presence or risk of cancer in a patient, comprises the steps of: (i) isolating a sample of the patient's genome; and (ii) detecting the presence or expression of the gene characterized by any of the nucleotide sequences identified as SEQ ID No 1, SEQ ID No. 10 and SEQ ID No. 13 wherein the presence or expression of the gene indicates the presence of or the risk of cancer.

Abstract translation: 一种用于检测患者癌症存在或风险的方法，包括以下步骤：（i）分离患者基因组的样品; 和（ii）检测以SEQ ID No 1，SEQ ID No.10和SEQ ID NO 13鉴定的任何核苷酸序列为特征的基因的存在或表达，其中基因的存在或表达表示存在或表达 癌症的风险。