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    CONCEPTS PERTAINING TO INTEGRATED SENSOR AND OPTICAL PHASE/AMPLITUDE MODULATOR
    22.
    发明申请
    CONCEPTS PERTAINING TO INTEGRATED SENSOR AND OPTICAL PHASE/AMPLITUDE MODULATOR 审中-公开

    公开(公告)号：US20180373065A1

    公开(公告)日：2018-12-27

    申请号：US16016193

    申请日：2018-06-22

    Applicant: California Institute of Technology

    Inventor： Changhuei Yang ,  Sylvain Gigan

    IPC: G02F1/01 ,  G02F1/19

    Abstract: An integrated sensor and optical phase/amplitude modulator device including a modulator stacked on or above a detector. A circuit receives a signal outputted from the detector in response to an input field irradiating the detector. The circuit performs binary operations comprising classifying the input phase of the input electromagnetic radiation into one of two ranges and setting the modulator into one of two states depending on which range the input phase is classified into. The modulator transmits output electromagnetic radiation having an output field modulated according to the state of the modulator set by the circuit.

    ARRAY LEVEL FOURIER PTYCHOGRAPHIC IMAGING
    23.
    发明申请
    ARRAY LEVEL FOURIER PTYCHOGRAPHIC IMAGING 有权
    阵列级FOORIER PTYCHOGRAPHIC IMAGING

    公开(公告)号：US20160216503A1

    公开(公告)日：2016-07-28

    申请号：US15007196

    申请日：2016-01-26

    Applicant: California Institute of Technology

    Inventor： Jinho Kim ,  Changhuei Yang

    IPC: G02B21/36 ,  G02B21/00 ,  G02B21/16

    CPC classification number: G02B21/365 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0446 ,  G02B13/0095 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/367 ,  H04N5/22541 ,  H04N5/2256 ,  H04N5/2258

    Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.

    Abstract translation: 在一个方面，成像系统包括：包括光源阵列的照明系统; 包括一个或多个透镜阵列的光学系统，每个透镜阵列包括透镜阵列，所述一个或多个透镜阵列中的每一个中的每个透镜与所述光源阵列的相应组的光源对准; 一种成像系统，包括图像传感器阵列，每个图像传感器与一个或多个透镜阵列的对应透镜或透镜组对准，每个图像传感器被配置为基于从所述一个或多个透镜阵列接收的光获取图像数据 相应的镜头或镜片组; 板接收器系统，其能够接收包括孔阵列的多孔板，所述板接收器系统被配置为使每个所述孔与所述图像传感器中的相应一个对准; 以及控制器，其被配置为控制所述光源的照明和由所述图像传感器获取图像数据，所述控制器还被配置为执行：包括多个扫描的图像获取处理，每个扫描与唯一的照明模式相关联， 每个图像传感器被配置为在每次扫描期间为相应的一个孔产生图像; 以及图像重建过程，在该图像重建过程期间，控制器基于在每个扫描期间针对相应的阱捕获的图像数据执行傅立叶ptychographic操作以生成每个孔的重建图像。

    Time-reversal of variance-encoded light (TROVE)
    25.
    发明授权
    Time-reversal of variance-encoded light (TROVE) 有权
    方差编码光的时间反转（TROVE）

    公开(公告)号：US09354166B2

    公开(公告)日：2016-05-31

    申请号：US14070045

    申请日：2013-11-01

    Applicant: California Institute of Technology

    Inventor： Benjamin Judkewitz ,  Ying Min Wang ,  Roarke Horstmeyer ,  Changhuei Yang

    IPC: G01N21/49 ,  G01N29/24 ,  G01N21/17 ,  G01N21/47 ,  G01N21/64 ,  G01N21/51

    CPC classification number: G01N21/49 ,  G01N21/1702 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N29/2418 ,  G01N2021/1708 ,  G01N2021/1727 ,  G01N2021/516

    Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.

    Abstract translation: 用于以更高分辨率照射散射介质的方法和装置。 该方法包括将EM辐射从电磁（EM）辐射源传输到散射介质内的目标，其中目标编码具有方差结构的EM辐射以形成编码的EM辐射; 在检测器中测量透射的EM辐射，所述EM辐射包括通过和离开所述散射介质的编码的EM辐射的至少一部分; 在计算机中对包括EM场的所发射的EM辐射进行解码，包括选择具有方差结构的一个或多个EM场; 以及从空间光调制器（SLM）向时间反转的EM辐射照射散射介质，时间反转的EM辐射是从具有方差结构的EM场反转的时间产生的，从而形成时间反射的EM辐射在散射介质中的焦点 随着分辨率的提高。

    MULTIPLEXED FOURIER PTYCHOGRAPHY IMAGING SYSTEMS AND METHODS
    26.
    发明申请
    MULTIPLEXED FOURIER PTYCHOGRAPHY IMAGING SYSTEMS AND METHODS 审中-公开
    多重傅立叶成像系统和方法

    公开(公告)号：US20160088205A1

    公开(公告)日：2016-03-24

    申请号：US14960252

    申请日：2015-12-04

    Applicant: California Institute of Technology

    Inventor： Roarke W. Horstmeyer ,  Guoan Zheng ,  Changhuei Yang

    IPC: H04N5/225 ,  H04N5/265 ,  H04N5/232

    CPC classification number: H04N5/2256 ,  G02B21/002 ,  G02B21/365 ,  G02B21/367 ,  G02B27/58 ,  G06K9/00134 ,  G21K7/00 ,  H04N5/23229 ,  H04N5/265

    Abstract: Certain embodiments pertain to Multiplexed Fourier Ptychographic imaging systems and methods. In one example, the Multiplexed Fourier Ptychographic imaging system includes an LED array configured to illuminate a sequence of LED patterns for illuminating a sample being imaged. The system includes LED circuitry configured to independently control power to turn on multiple LEDs simultaneously in each LED pattern of the array. The system has a light detector that acquires a first set of lower resolution images of the sample each image acquired during exposure time during illumination by a unique LED pattern. The system uses the first set of lower resolution images to generate a second set of lower resolution images associated with each LED in the LED array and iteratively updates overlapping regions in the Fourier domain with the second set of lower resolution images to generate a higher resolution image.

    Abstract translation: 某些实施例涉及多路复用傅立叶Ptychographic成像系统和方法。 在一个示例中，多路复用傅立叶谱图成像系统包括被配置为照亮一系列LED图案以照亮被成像的样本的LED阵列。 该系统包括配置成独立控制电源以在阵列的每个LED图案中同时打开多个LED的LED电路。 该系统具有光检测器，其通过独特的LED图案在照明期间获取在曝光时间期间获取的每个图像的第一组较低分辨率图像。 该系统使用第一组较低分辨率图像来产生与LED阵列中的每个LED相关联的第二组较低分辨率图像，并且用第二组较低分辨率图像迭代地更新傅立叶域中的重叠区域以产生较高分辨率图像 。

    FREE ORIENTATION FOURIER CAMERA
    27.
    发明申请
    FREE ORIENTATION FOURIER CAMERA 审中-公开
    免费定位FOURIER CAMERA

    公开(公告)号：US20150264250A1

    公开(公告)日：2015-09-17

    申请号：US14658019

    申请日：2015-03-13

    Applicant: California Institute of Technology

    Inventor： Xiaoze Ou ,  Changhuei Yang

    IPC: H04N5/232 ,  G06T7/00 ,  G06T3/40

    CPC classification number: G06T7/0012 ,  A61B5/0059 ,  A61B5/444 ,  G02B27/46

    Abstract: Certain aspects pertain to Fourier camera systems and methods. In one aspect, a Fourier camera comprises a first optical system, a second optical system, a variable aperture filter, and a light detector. The first optical system configured to receive illumination reflected from a curved sample surface. The variable aperture filter configured to move an aperture to a plurality of aperture locations in a Fourier plane, wherein the aperture filters light from the first optical system to the second optical system. The light detector configured to receive light from the second optical system, and configured to acquire a plurality of raw intensity images of the curved sample surface corresponding to the plurality of aperture locations, wherein the raw images are iteratively updated in overlapping regions in Fourier space to generate a focused, substantially uniform resolution image of the curved sample surface, and wherein the overlapping regions correspond to the plurality of aperture locations.

    Abstract translation: 某些方面涉及傅里叶相机系统和方法。 一方面，傅里叶相机包括第一光学系统，第二光学系统，可变孔径滤光器和光检测器。 第一光学系统被配置为接收从弯曲的样品表面反射的照明。 可变孔径滤波器被配置为将光圈移动到傅立叶平面中的多个孔径位置，其中，孔径将来自第一光学系统的光滤波到第二光学系统。 所述光检测器被配置为从所述第二光学系统接收光，并且被配置为获取与所述多个孔位置相对应的所述弯曲样品表面的多个原始强度图像，其中，所述原始图像在傅立叶空间中的重叠区域中被迭代地更新为 产生弯曲样品表面的聚焦的，基本均匀的分辨率图像，并且其中重叠区域对应于多个孔位置。

    Fourier Ptychographic Imaging Systems, Devices, and Methods
    29.
    发明申请
    Fourier Ptychographic Imaging Systems, Devices, and Methods 审中-公开
    傅立叶Ptychographic成像系统，设备和方法

    公开(公告)号：US20140118529A1

    公开(公告)日：2014-05-01

    申请号：US14065280

    申请日：2013-10-28

    Applicant: California Institute of Technology

    Inventor： Guoan Zheng ,  Changhuei Yang ,  Roarke Horstmeyer

    IPC: G06K9/00

    Abstract: Systems, devices, and methods of Fourier ptychographic imaging by computationally reconstructing a high-resolution image by iteratively updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space.

    Abstract translation: 通过迭代更新傅立叶空间中可变照明的低分辨率强度图像的重叠区域，通过计算重建高分辨率图像来进行傅里叶图像成像的系统，设备和方法。

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