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公开(公告)号：US20220351347A1
公开(公告)日：2022-11-03
申请号：US17652667
申请日：2022-02-25
Applicant: California Institute of Technology , Washington University
Inventor： Changhuei Yang , Cheng Shen , Richard J. Cote , Siddarth Rawal
Abstract: Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.
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公开(公告)号：US20220103348A1
公开(公告)日：2022-03-31
申请号：US17487924
申请日：2021-09-28
Applicant: California Institute of Technology
Inventor： Jian Xu , Changhuei Yang
IPC: H04L9/06 , G02B27/48 , H04B10/54 , H04B10/66 , H04B10/2537
Abstract: A communication system including a first detector; a first scattering medium; a second detector; an intensity modulator; a second scattering medium; wherein electromagnetic radiation transmitted from a first spot at the first scattering medium, and scattered by and through the first scattering medium and then the second scattering medium, forms a first speckle pattern detected by the second detector. The intensity modulator outputs a second spot of electromagnetic radiation representing the “ones” in a data stream at locations of the bright speckles (or at locations of the dark speckles to represent the “zeros” in the data stream) so that the electromagnetic radiation, transmitted from the second spot and scattered by and through the second scattering medium and then the first scattering medium, forms one or more second bright or dark speckles on the first detector. The data stream can be constructed from the second bright or dark speckles.
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公开(公告)号：US10754140B2
公开(公告)日：2020-08-25
申请号：US16179688
申请日：2018-11-02
Applicant: California Institute of Technology
Inventor： Chi Shing Chan , Changhuei Yang
Abstract: Certain embodiments pertain to parallel digital imaging acquisition and restoration methods and systems.
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公开(公告)号：US10679763B2
公开(公告)日：2020-06-09
申请号：US14065280
申请日：2013-10-28
Applicant: California Institute of Technology
Inventor： Guoan Zheng , Changhuei Yang , Roarke Horstmeyer
Abstract: Systems, devices, and methods of Fourier ptychographic imaging configured for illuminating a specimen being imaged from a plurality of incidence angles, for acquiring variably-illuminated, low-resolution intensity images of the specimen, and for reconstructing a high-resolution image of the specimen by iteratively determining the high resolution image that is self-consistent with the variably-illuminated, low-resolution intensity images, for example, by updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space.
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公开(公告)号：US10228550B2
公开(公告)日：2019-03-12
申请号：US15160941
申请日：2016-05-20
Applicant: California Institute of Technology
Inventor： Xiaoze Ou , Jaebum Chung , Changhuei Yang
Abstract: Certain embodiments pertain to laser-based Fourier ptychographic (LFP) imaging systems, angle direction devices used in the LFP imaging systems, optical switches used in the LFP imaging systems, and LFP imaging methods. The LFP systems include an angle direction device for directing laser light to a sample plane at a plurality of illumination angles at different sample times. The LFP systems also include an optical system and a light detector. The optical system receives light issuing from the sample being imaged and propagates and focuses the light to the light detector acquiring raw intensity images.
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Patent Agency Ranking
公开(公告)号：US10203274B2
公开(公告)日：2019-02-12
申请号：US15181160
申请日：2016-06-13
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Mooseok Jang , Changhuei Yang , Daifa Wang
Abstract: A method for irradiating scattering medium, including modifying a particle's response to electromagnetic radiation irradiating the particle in a scattering medium, wherein the electromagnetic radiation is scattered by the scattering medium, and modulated by the modifying, into scattered electromagnetic radiation comprising a scattered field; forming a phase conjugate field, wherein the phase conjugate field is a phase conjugate of the scattered field; and irradiating the scattering medium with the phase conjugate field, wherein the phase conjugate field forms a focus at a target defined by the particle.
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公开(公告)号：US10194100B2
公开(公告)日：2019-01-29
申请号：US15332959
申请日：2016-10-24
Applicant: California Institute of Technology
Inventor： Edward H. Zhou , Joshua Brake , Changhuei Yang
Abstract: A method of imaging an object on one or more sensor pixels and with reduced glare. The method includes irradiating a scattering medium and the object behind the scattering medium, creating backscattered radiation and imaging radiation that are received on the one or more pixels. The method includes digitally adjusting a phase, an amplitude, or a phase and amplitude, of reference radiation transmitted onto the one or more sensor pixels, wherein the reference radiation destructively interferes with the backscattered radiation (glare) on the one or more sensor pixels while the object is imaged on the one or more sensor pixels using the imaging radiation.
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8.发明申请公开(公告)号：US20170118423A1
公开(公告)日：2017-04-27
申请号：US15332959
申请日：2016-10-24
Applicant: California Institute of Technology
Inventor： Edward H. Zhou , Joshua Brake , Changhuei Yang
CPC classification number: H04N5/357 , G02B26/06 , G02B27/0068 , G02B27/1066 , H04N5/2254 , H04N5/2354
Abstract: A method of imaging an object on one or more sensor pixels and with reduced glare. The method includes irradiating a scattering medium and the object behind the scattering medium, creating backscattered radiation and imaging radiation that are received on the one or more pixels. The method includes digitally adjusting a phase, an amplitude, or a phase and amplitude, of reference radiation transmitted onto the one or more sensor pixels, wherein the reference radiation destructively interferes with the backscattered radiation (glare) on the one or more sensor pixels while the object is imaged on the one or more sensor pixels using the imaging radiation.
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公开(公告)号：US09569664B2
公开(公告)日：2017-02-14
申请号：US14072652
申请日：2013-11-05
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Guoan Zheng , Samuel Yang , Seung Ah Lee , Shuo Pang , Changhuei Yang , Ying Min Wang
CPC classification number: G06K9/00624 , B01L3/502792 , B01L3/508 , B01L2300/0654 , C12M41/36 , G01N21/03 , G01N21/25 , G01N21/272 , G01N2201/10
Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.
Abstract translation: 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。
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公开(公告)号：US20160320595A1
公开(公告)日：2016-11-03
申请号：US15206859
申请日：2016-07-11
Applicant: California Institute of Technology
Inventor： Roarke W. Horstmeyer , Guoan Zheng , Xiaoze Ou , Changhuei Yang
IPC: G02B21/00
CPC classification number: G02B21/008 , G01N23/205 , G01T1/185 , G01T3/008 , G02B21/0032 , G02B21/0048 , G02B21/0056 , G02B21/006 , G02B21/16 , G02B21/367 , G02B27/46 , G02B27/58
Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.
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