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公开(公告)号：US09569664B2
公开(公告)日：2017-02-14
申请号：US14072652
申请日：2013-11-05
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Guoan Zheng , Samuel Yang , Seung Ah Lee , Shuo Pang , Changhuei Yang , Ying Min Wang
CPC classification number: G06K9/00624 , B01L3/502792 , B01L3/508 , B01L2300/0654 , C12M41/36 , G01N21/03 , G01N21/25 , G01N21/272 , G01N2201/10
Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.
Abstract translation: 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。
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公开(公告)号：US09354166B2
公开(公告)日：2016-05-31
申请号：US14070045
申请日：2013-11-01
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Ying Min Wang , Roarke Horstmeyer , Changhuei Yang
CPC classification number: G01N21/49 , G01N21/1702 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N29/2418 , G01N2021/1708 , G01N2021/1727 , G01N2021/516
Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.
Abstract translation: 用于以更高分辨率照射散射介质的方法和装置。 该方法包括将EM辐射从电磁（EM）辐射源传输到散射介质内的目标，其中目标编码具有方差结构的EM辐射以形成编码的EM辐射; 在检测器中测量透射的EM辐射，所述EM辐射包括通过和离开所述散射介质的编码的EM辐射的至少一部分; 在计算机中对包括EM场的所发射的EM辐射进行解码，包括选择具有方差结构的一个或多个EM场; 以及从空间光调制器（SLM）向时间反转的EM辐射照射散射介质，时间反转的EM辐射是从具有方差结构的EM场反转的时间产生的，从而形成时间反射的EM辐射在散射介质中的焦点 随着分辨率的提高。
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3.发明授权Deep tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light 有权深层组织聚焦荧光成像与数字时间反转超声编码光公开(公告)号：US09313423B2
公开(公告)日：2016-04-12
申请号：US13851901
申请日：2013-03-27
Inventor： Ying Min Wang , Benjamin Judkewitz , Charles A. DiMarzio , Changhuei Yang
IPC: G02F1/11 , H04N5/30 , A61N5/00 , G01N27/447
CPC classification number: H04N5/30 , A61N5/00 , G01N27/44721 , G02F1/11
Abstract: A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.
Abstract translation: 使用超声波源，相干光源，包括照相机和空间光调制器（SLM）的数字光学相位共轭（DOPC）装置，用数字时间反转的超声波编码光进行荧光成像的装置和方法， 荧光检测器和一个或多个计算机，以获得至少近似于所有编码光场的完整时间反转场与散射介质之间的相互作用的输出。
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公开(公告)号：US09279972B2
公开(公告)日：2016-03-08
申请号：US14068818
申请日：2013-10-31
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Changhuei Yang
CPC classification number: G02B21/0056 , G02B5/1828 , G02B21/0076 , G02B21/367 , G02B27/58
Abstract: Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency.
Abstract translation: 空间频率扫描干涉（SFSI）照明和成像方法和装置，其干扰两个准直相干光以产生具有扫描空间频率的多个照明片的干涉图案。
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Patent Agency Ranking
公开(公告)号：US20140139840A1
公开(公告)日：2014-05-22
申请号：US14068818
申请日：2013-10-31
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Changhuei Yang
IPC: G02B21/06
CPC classification number: G02B21/0056 , G02B5/1828 , G02B21/0076 , G02B21/367 , G02B27/58
Abstract: Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency.
Abstract translation: 空间频率扫描干涉（SFSI）照明和成像方法和装置，其干扰两个准直相干光束以产生具有扫描空间频率的多个照明片的干涉图案。
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公开(公告)号：US20150241342A1
公开(公告)日：2015-08-27
申请号：US14631684
申请日：2015-02-25
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Haojiang Zhou , Benjamin Judkewitz , Changhuei Yang
CPC classification number: G01N15/1425 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N21/4788 , G01N21/53 , G01N2015/0046 , G01N2015/0053 , G01N2015/1006 , G01N2015/145 , G01N2015/1452 , G01N2015/1454 , G01N2021/479 , G01N2201/0675
Abstract: A method for irradiating a scattering medium, including irradiating a scattering medium with radiation from a laser, to form scattered radiation having a scattered field; measuring a difference in the scattered field caused by motion of a moving target in or behind the scattering medium; forming a phase conjugate of the difference to form a phase conjugate field; and irradiating the scattering medium with the phase conjugate field formed using one or more radiation modulating elements. Thus we present that movement of objects can be used as a novel guide star in Digital Optical Phase Conjugation (DOPC). By time reversal of difference of scattering fields of a moving target, light can be focused through scattering media.
Abstract translation: 一种用于照射散射介质的方法，包括用来自激光器的辐射照射散射介质，以形成具有散射场的散射辐射; 测量由散射介质中或其后面的移动目标的运动引起的散射场的差异; 形成所述差的相位共轭以形成相位共轭场; 以及使用一个或多个辐射调制元件形成的相位共轭场辐射散射介质。 因此，我们提出物体的移动可以用作数字光相位共轭（DOPC）中的新型导星。 通过时间反转移动目标的散射场的差异，可以通过散射介质聚焦光。
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公开(公告)号：US09054871B2
公开(公告)日：2015-06-09
申请号：US13773490
申请日：2013-02-21
Applicant: California Institute of Technology
Inventor： Roarke Horstmeyer , Benjamin Judkewitz , Changhuei Yang , Ivo M. Vellekoop
CPC classification number: H04L9/28 , G09C1/00 , G09C5/00 , H04L9/0656 , H04L9/0841 , H04L9/0866 , H04L9/0897 , H04L27/2278 , H04L27/3818
Abstract: A device, including one or more Communication Physical Unclonable Function (CPUF) and key storage devices, the CPUF devices each including: a coherent Electromagnetic (EM) radiation source; a spatial light modulator (SLM) connected to the coherent EM radiation source; a volumetric scattering medium connected to the SLM; a detector connected to the volumetric scattering medium; and one or more processors or circuits connected to the detector and one or more processors or circuits connected to the SLM. A communication protocol is also provided.
Abstract translation: 一种包括一个或多个通信物理不可克隆功能（CPUF）和密钥存储设备的设备，每个CPUF设备包括：相干电磁（EM）辐射源; 连接到相干EM辐射源的空间光调制器（SLM） 连接到SLM的体积散射介质; 连接到体积散射介质的检测器; 以及连接到检测器的一个或多个处理器或电路以及连接到SLM的一个或多个处理器或电路。 还提供通信协议。
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公开(公告)号：US20140133702A1
公开(公告)日：2014-05-15
申请号：US14072652
申请日：2013-11-05
Applicant: California Institute of Technology
Inventor： Guoan Zheng , Samuel Yang , Seung Ah Lee , Shuo Pang , Changhuei Yang , Benjamin Judkewitz , Ying Min Wang
IPC: G06K9/00
CPC classification number: G06K9/00624 , B01L3/502792 , B01L3/508 , B01L2300/0654 , C12M41/36 , G01N21/03 , G01N21/25 , G01N21/272 , G01N2201/10
Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.
Abstract translation: 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。
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公开(公告)号：US20140118739A1
公开(公告)日：2014-05-01
申请号：US14070045
申请日：2013-11-01
Applicant: California Institute of Technology
Inventor： Benjamin Judkewitz , Ying Min Wang , Roarke Horstmeyer , Changhuei Yang
IPC: G01N21/49
CPC classification number: G01N21/49 , G01N21/1702 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N29/2418 , G01N2021/1708 , G01N2021/1727 , G01N2021/516
Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.
Abstract translation: 用于以更高分辨率照射散射介质的方法和装置。 该方法包括将EM辐射从电磁（EM）辐射源传输到散射介质内的目标，其中目标编码具有方差结构的EM辐射以形成编码的EM辐射; 在检测器中测量透射的EM辐射，所述EM辐射包括通过和离开所述散射介质的编码的EM辐射的至少一部分; 在计算机中对包括EM场的所发射的EM辐射进行解码，包括选择具有方差结构的一个或多个EM场; 以及从空间光调制器（SLM）向时间反转的EM辐射照射散射介质，时间反转的EM辐射是从具有方差结构的EM场反转的时间产生的，由此形成时间反射的EM辐射在散射介质中的焦点 随着分辨率的提高。
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