公开(公告)号：US09569664B2

公开(公告)日：2017-02-14

申请号：US14072652

申请日：2013-11-05

Applicant: California Institute of Technology

Inventor： Benjamin Judkewitz ,  Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang ,  Ying Min Wang

IPC: G06K9/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  C12M1/34 ,  B01L3/00

CPC classification number: G06K9/00624 ,  B01L3/502792 ,  B01L3/508 ,  B01L2300/0654 ,  C12M41/36 ,  G01N21/03 ,  G01N21/25 ,  G01N21/272 ,  G01N2201/10

Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.

Abstract translation: 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。

公开(公告)号：US09313423B2

公开(公告)日：2016-04-12

申请号：US13851901

申请日：2013-03-27

Applicant: California Institute of Technology ,  Northeastern University

Inventor： Ying Min Wang ,  Benjamin Judkewitz ,  Charles A. DiMarzio ,  Changhuei Yang

IPC: G02F1/11 ,  H04N5/30 ,  A61N5/00 ,  G01N27/447

CPC classification number: H04N5/30 ,  A61N5/00 ,  G01N27/44721 ,  G02F1/11

Abstract: A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.

Abstract translation: 使用超声波源，相干光源，包括照相机和空间光调制器（SLM）的数字光学相位共轭（DOPC）装置，用数字时间反转的超声波编码光进行荧光成像的装置和方法， 荧光检测器和一个或多个计算机，以获得至少近似于所有编码光场的完整时间反转场与散射介质之间的相互作用的输出。

公开(公告)号：US20140133702A1

公开(公告)日：2014-05-15

申请号：US14072652

申请日：2013-11-05

Applicant: California Institute of Technology

Inventor： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang ,  Benjamin Judkewitz ,  Ying Min Wang

IPC: G06K9/00

CPC classification number: G06K9/00624 ,  B01L3/502792 ,  B01L3/508 ,  B01L2300/0654 ,  C12M41/36 ,  G01N21/03 ,  G01N21/25 ,  G01N21/272 ,  G01N2201/10

Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.

Abstract translation: 快速区分生长细胞和碎片的方法，其确定标本图像的延时电影，跟踪每个实体的特征，并将每个实体分类为生长细胞或碎片。

公开(公告)号：US20140118739A1

公开(公告)日：2014-05-01

申请号：US14070045

申请日：2013-11-01

Applicant: California Institute of Technology

Inventor： Benjamin Judkewitz ,  Ying Min Wang ,  Roarke Horstmeyer ,  Changhuei Yang

IPC: G01N21/49

CPC classification number: G01N21/49 ,  G01N21/1702 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N29/2418 ,  G01N2021/1708 ,  G01N2021/1727 ,  G01N2021/516

Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.

Abstract translation: 用于以更高分辨率照射散射介质的方法和装置。 该方法包括将EM辐射从电磁（EM）辐射源传输到散射介质内的目标，其中目标编码具有方差结构的EM辐射以形成编码的EM辐射; 在检测器中测量透射的EM辐射，所述EM辐射包括通过和离开所述散射介质的编码的EM辐射的至少一部分; 在计算机中对包括EM场的所发射的EM辐射进行解码，包括选择具有方差结构的一个或多个EM场; 以及从空间光调制器（SLM）向时间反转的EM辐射照射散射介质，时间反转的EM辐射是从具有方差结构的EM场反转的时间产生的，由此形成时间反射的EM辐射在散射介质中的焦点 随着分辨率的提高。

公开(公告)号：US09354166B2

公开(公告)日：2016-05-31

申请号：US14070045

申请日：2013-11-01

Applicant: California Institute of Technology

Inventor： Benjamin Judkewitz ,  Ying Min Wang ,  Roarke Horstmeyer ,  Changhuei Yang

IPC: G01N21/49 ,  G01N29/24 ,  G01N21/17 ,  G01N21/47 ,  G01N21/64 ,  G01N21/51

CPC classification number: G01N21/49 ,  G01N21/1702 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N29/2418 ,  G01N2021/1708 ,  G01N2021/1727 ,  G01N2021/516

Abstract: A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.

Abstract translation: 用于以更高分辨率照射散射介质的方法和装置。 该方法包括将EM辐射从电磁（EM）辐射源传输到散射介质内的目标，其中目标编码具有方差结构的EM辐射以形成编码的EM辐射; 在检测器中测量透射的EM辐射，所述EM辐射包括通过和离开所述散射介质的编码的EM辐射的至少一部分; 在计算机中对包括EM场的所发射的EM辐射进行解码，包括选择具有方差结构的一个或多个EM场; 以及从空间光调制器（SLM）向时间反转的EM辐射照射散射介质，时间反转的EM辐射是从具有方差结构的EM场反转的时间产生的，从而形成时间反射的EM辐射在散射介质中的焦点 随着分辨率的提高。