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公开(公告)号：US11156960B2
公开(公告)日：2021-10-26
申请号：US16058498
申请日：2018-08-08
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Jacob Berlin , Tom Haber , Changhuei Yang
IPC: G01N21/47 , G03H1/04 , G01N33/483 , G03H1/22 , G03H1/00
Abstract: A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.
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2.发明申请公开(公告)号：US20190064736A1
公开(公告)日：2019-02-28
申请号：US16058498
申请日：2018-08-08
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Jacob Berlin , Tom Haber , Changhuei Yang
IPC: G03H1/04 , G01N21/47 , G01N33/483
Abstract: A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.
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公开(公告)号：US11835733B2
公开(公告)日：2023-12-05
申请号：US17023070
申请日：2020-09-16
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Changhuei Yang , Jian Xu
CPC classification number: G02B27/48 , G02B26/0833 , G02B26/105 , H04B10/504 , H04B10/61
Abstract: Optical wavefront shaping has been the standard technique to control light through scattering media. Implicit in this dominance is the assumption that knowledge of the optical phase is a necessity for optical control through scattering media. In this paper, we challenge this assumption by reporting on an intensity-only approach for light control through (or reflected from) a disordered scattering medium—optical-channel-based intensity streaming (OCIS). Instead of actively tuning the interference between the optical paths via wavefront shaping, OCIS can control light and transmit information through or from scattering media with linear intensity operation, which not only simplifies and speeds up the system but also enables new applications. We experimentally created focus patterns through scattering media in a sub-millisecond timescale with a phase-manipulation-free setup. We also demonstrate that, unlike wavefront shaping, OCIS can readily generate distinct energy null points through scattering media. Finally, we demonstrate that OCIS enables a scattering medium mediated secure optical communication application.
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Patent Agency Ranking
公开(公告)号：US11471326B2
公开(公告)日：2022-10-18
申请号：US16178190
申请日：2018-11-01
Applicant: California Institute of Technology
Inventor： Lihong Wang , Frank L. Brodie , Yuecheng Shen , Yan Liu , Haowen Ruan
Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
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5.发明申请OPTICAL FOCUSING INSIDE SCATTERING MEDIA WITH TIME-REVERSED ULTRASOUND MICROBUBBLE ENCODED (TRUME) LIGHT 审中-公开光学聚焦内置散射介质与时间反射超声波编码（TRUME）灯公开(公告)号：US20160363527A1
公开(公告)日：2016-12-15
申请号：US15181160
申请日：2016-06-13
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Mooseok Jang , Changhuei Yang , Daifa Wang
CPC classification number: G01N15/14 , A61B5/00 , A61B5/0097 , A61B8/0891 , A61B8/481 , G01N21/453 , G01N21/4788 , G01N21/4795 , G01N2021/473
Abstract: A method for irradiating scattering medium, including modifying a particle's response to electromagnetic radiation irradiating the particle in a scattering medium, wherein the electromagnetic radiation is scattered by the scattering medium, and modulated by the modifying, into scattered electromagnetic radiation comprising a scattered field; forming a phase conjugate field, wherein the phase conjugate field is a phase conjugate of the scattered field; and irradiating the scattering medium with the phase conjugate field, wherein the phase conjugate field forms a focus at a target defined by the particle.
Abstract translation: 一种用于照射散射介质的方法，包括改变颗粒对散射介质中照射颗粒的电磁辐射的响应，其中电磁辐射被散射介质散射并通过修改调制成包括散射场的散射电磁辐射; 形成相位共轭场，其中所述相位共轭场是所述散射场的相位共轭; 以及用所述相位共轭场辐射所述散射介质，其中所述相位共轭场在由所述粒子限定的目标处形成焦点。
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公开(公告)号：US20210080742A1
公开(公告)日：2021-03-18
申请号：US17023070
申请日：2020-09-16
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Changhuei Yang , Jian Xu
Abstract: Optical wavefront shaping has been the standard technique to control light through scattering media. Implicit in this dominance is the assumption that knowledge of the optical phase is a necessity for optical control through scattering media. In this paper, we challenge this assumption by reporting on an intensity-only approach for light control through (or reflected from) a disordered scattering medium—optical-channel-based intensity streaming (OCIS). Instead of actively tuning the interference between the optical paths via wavefront shaping, OCIS can control light and transmit information through or from scattering media with linear intensity operation, which not only simplifies and speeds up the system but also enables new applications. We experimentally created focus patterns through scattering media in a sub-millisecond timescale with a phase-manipulation-free setup. We also demonstrate that, unlike wavefront shaping, OCIS can readily generate distinct energy null points through scattering media. Finally, we demonstrate that OCIS enables a scattering medium mediated secure optical communication application.
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公开(公告)号：US20190125583A1
公开(公告)日：2019-05-02
申请号：US16178190
申请日：2018-11-01
Applicant: California Institute of Technology
Inventor： Lihong Wang , Frank L. Brodie , Yuecheng Shen , Yan Liu , Haowen Ruan
IPC: A61F9/008
Abstract: A device for irradiating ocular tissue, including a source of electromagnetic radiation; a beacon scattering the electromagnetic radiation transmitted through an opacity in ocular tissue so as to form scattered electromagnetic radiation; a modulator transmitting output electromagnetic radiation having a field determined from a recording of the scattered electromagnetic radiation transmitted through the opacity, so that the output electromagnetic radiation is transmitted through the opacity to the beacon. The device can be used to treat amblyopia or correct optical aberrations in corneal or lens tissue.
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公开(公告)号：US10203274B2
公开(公告)日：2019-02-12
申请号：US15181160
申请日：2016-06-13
Applicant: California Institute of Technology
Inventor： Haowen Ruan , Mooseok Jang , Changhuei Yang , Daifa Wang
Abstract: A method for irradiating scattering medium, including modifying a particle's response to electromagnetic radiation irradiating the particle in a scattering medium, wherein the electromagnetic radiation is scattered by the scattering medium, and modulated by the modifying, into scattered electromagnetic radiation comprising a scattered field; forming a phase conjugate field, wherein the phase conjugate field is a phase conjugate of the scattered field; and irradiating the scattering medium with the phase conjugate field, wherein the phase conjugate field forms a focus at a target defined by the particle.
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