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    Methods of manufacturing superconductor and phononic elements
    21.
    发明授权
    Methods of manufacturing superconductor and phononic elements 有权

    公开(公告)号：US10439125B2

    公开(公告)日：2019-10-08

    申请号：US16069508

    申请日：2017-01-12

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Milan Allan

    IPC: H01L39/12 ,  H01L39/24

    Abstract: There is provided methods of manufacturing a superconductor element and a method of manufacturing a phononic element. The method of manufacturing a superconductor element comprises the step of forming a periodic patterned structure in a material to alter an electronic structure in a primary layer (M) of the material to couple with the or each phonon of the primary layer (M) so as to induce superconductivity in the primary layer (M) or modify the superconductivity of the primary layer, and/or create or alter one or more phonons in a primary layer (M) of the material to couple with the electrons of the primary layer (M) so as to induce superconductivity in the primary layer (M) or modify the superconductivity of the primary layer. The method of manufacturing a phononic element comprises the steps of: providing one of a primary layer (M) and a secondary layer (M2) of a material on the other of the primary layer (M) and secondary layer (M2) of the material; and forming a periodic patterned structure in the secondary layer (M2) to create or alter one or more phonons in the primary layer (M).

    GLYCOSYLATED METABOLITES
    22.
    发明申请
    GLYCOSYLATED METABOLITES 审中-公开

    公开(公告)号：US20190195897A1

    公开(公告)日：2019-06-27

    申请号：US15739043

    申请日：2016-06-24

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Johannes Maria Franciscus Gerardus AERTS ,  Hermen Steven OVERKLEEFT

    IPC: G01N33/82 ,  A61K31/445 ,  G01N33/68 ,  G01N33/92

    CPC classification number: G01N33/82 ,  A61K31/445 ,  C12Q1/48 ,  G01N33/6893 ,  G01N33/92 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2560/00

    Abstract: The invention provides means and methods for detecting a glycosylated metabolite in a sample comprising adding to the sample a compound comprising a labelled glycosyl group coupled via an O-glycosidic bond to an aglycon with a specific structural formula wherein the glycosyl group comprises at least one isotope and/or a side chain being a label for detection, and wherein the sample is screened for the presence of a glycosylated metabolite with the glycosyl group other than a glucosylceramide. The invention further provides a method of treating a disorder caused by accumulation of a glycosylated metabolite other than glucosylceramide in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a glucosylceramide synthase (GCS) inhibitor.

    Fluid triggerable valves
    28.
    发明授权
    Fluid triggerable valves 有权
    流体触发阀

    公开(公告)号：US09429249B2

    公开(公告)日：2016-08-30

    申请号：US14465345

    申请日：2014-08-21

    Applicant: Universiteit Leiden

    Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Ender Yildirim

    IPC: B01L99/00 ,  F16K99/00 ,  B01L3/00

    CPC classification number: F16K99/0026 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2400/0406 ,  B01L2400/0688 ,  F16K2099/0084 ,  Y10T137/7859

    Abstract: The present invention relates to a fluid triggerable passive valve for controlling flow of one or more fluids comprising: a volume comprising at least two capillary pressure barriers for respectively pinning a first and second fluid-fluid meniscus, the two capillary pressure barriers dividing the volume in at least three sub volumes, whereby two sub volumes being positioned upstream and one sub volume being positioned downstream with respect to the advancement direction of each respective fluid-fluid meniscus; wherein the capillary pressure barriers are spaced apart such that upon pinning of a first fluid-fluid meniscus on a first capillary pressure barrier and arrival or pinning of a second fluid-fluid meniscus on or at a second capillary pressure barrier, the two menisci touch and thereby coalesce into one fluid-fluid meniscus.

    Abstract translation: 本发明涉及一种用于控制一种或多种流体流动的流体可触发的被动阀，包括：一个体积，包括至少两个用于分别固定第一和第二流体 - 液体弯液面的毛细管压力屏障，两个毛细管压力屏障将体积分成 至少三个子体积，其中两个子体积位于上游，一个子体积相对于每个相应的流体 - 液体弯液面的前进方向位于下游; 其中所述毛细管压力屏障间隔开，使得当在第一毛细管压力屏障上锁定第一流体 - 液体弯液面并且在第二毛细管压力屏障上或在第二毛细管压力屏障上到达或钉住第二流体 - 液体弯月面时，两个半月板触摸和 从而聚结成一个流体 - 液体弯液面。

    AN APPARATUS FOR ENABLING WIDE-FIELD POLARIMETRY
    29.
    发明申请
    AN APPARATUS FOR ENABLING WIDE-FIELD POLARIMETRY 有权
    用于实现广域极性测量的装置

    公开(公告)号：US20150355022A1

    公开(公告)日：2015-12-10

    申请号：US14761328

    申请日：2014-01-16

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Christoph Ulrich Keller ,  Frans Snik

    IPC: G01J3/02 ,  G01J4/04 ,  G01J1/42 ,  G02F1/01 ,  G01J1/04

    CPC classification number: G01J3/0224 ,  G01J1/0425 ,  G01J1/4228 ,  G01J3/0218 ,  G01J3/14 ,  G01J4/00 ,  G01J4/04 ,  G02F1/0136

    Abstract: A polarimetry apparatus comprising a plurality of flexible light conduits each having first and second ends, and a respective polarization modulator associated with each light conduit, wherein each light conduit is configured to receive incident light from a different predetermined region in space via the first end, and deliver said light to a detector unit via the second end, and wherein the polarization modulator is configured to modulate the polarization of the light to enable a partial or complete polarization state of the incident light to be determined by the detector unit for each light conduit.

    Abstract translation: 一种包括多个具有第一和第二端的柔性光导管以及与每个光导管相关联的相应的偏振调制器的偏振仪，其中每个光导管经配置以经由第一端接收来自不同预定区域的入射光， 并且经由所述第二端将所述光传送到检测器单元，并且其中所述偏振调制器被配置为调制所述光的偏振，以使所述入射光的部分或完全偏振状态由所述检测器单元确定用于每个光导管 。

    ELECTROEXTRACTION
    30.
    发明申请
    ELECTROEXTRACTION 有权
    电解

    公开(公告)号：US20150129427A1

    公开(公告)日：2015-05-14

    申请号：US14394895

    申请日：2013-04-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Robert-Jan Raterink ,  Peter Lindenburg ,  Thomas Hankemeier

    IPC: B03C5/02

    CPC classification number: B03C5/02 ,  B01D11/0419 ,  B01D57/02 ,  B01D61/246 ,  B01D61/38 ,  B01D61/42 ,  G01N1/4005 ,  G01N27/44756 ,  G01N2001/4011 ,  G01N2001/4038 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2035/1053

    Abstract: The present invention relates to a process for the extraction of analyte compounds from a sample comprising one or more analytes in a donor phase into an acceptor phase, comprising the steps of: a) providing an electrically conductive donor phase comprising the compounds in a first electrically conductive solvent or solvent blend, and an electrode arranged in electrically conductive contact with the donor phase, b) providing an electrically conductive acceptor phase in electrically conductive contact with a second electrode; and c) providing an insulator phase in fluid communication with at least one of the donor phase and the acceptor phase, wherein the insulator phase is immiscible with the donor phase and/or the acceptor phase, and d) (d) applying an electrical field between the first and the second electrode.

    Abstract translation: 本发明涉及一种从包含供体相中的一种或多种分析物的样品中提取分析物质到受体相中的方法，所述方法包括以下步骤：a）提供包含所述化合物的导电供体相， 导电溶剂或溶剂共混物，以及布置成与供体相导电接触的电极，b）提供与第二电极导电接触的导电受体相; 以及c）提供与供体相和受体相中的至少一个流体连通的绝缘体相，其中绝缘体相与施主相和/或受体相不混溶，以及d）（d）施加电场 在第一和第二电极之间。

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