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公开(公告)号：US20150075300A1
公开(公告)日：2015-03-19
申请号：US14384943
申请日：2013-03-12
Applicant: UNIVERSITEIT LEIDEN
Inventor： Thomas Hankemeier , Jan-Willem Schoonen , Heiko Jan Van Der Linden , Paul Vulto
CPC classification number: G01N30/12 , B01D1/00 , G01N1/2214 , G01N1/2273 , G01N1/24 , G01N1/4022 , G01N1/405 , G01N30/463 , G01N30/62 , G01N2001/2223 , G01N2001/4027 , G01N2030/027 , G01N2030/126
Abstract: The present invention relates to a device and an arrangement for selective solvent evaporation from a liquid feed, the feed comprising one or more components diluted in at least a first solvent or a solvent blend, comprising: a) a first tubular vessel having a distal end or a channel suitable for the formation of a droplet of a first volume, at an inflow rate n, at the tip or in the lumen of the tubular vessel, and b) means for subjecting the droplet to a solvent removal step at an evaporation rate r2 to evaporate at least part of the first solvent or solvent blend, to accumulate the components in the feed in the droplet during the evaporation process at an accumulation rate r3, to obtain a concentrated feed volume in a concentrated droplet, wherein the evaporation and/or inflow rates are continuously adjusted to achieve a desired accumulation rate. The invention further relates to a method for selective solvent removal from an analyte mixture obtained in a chromatographic separation process.
Abstract translation: 本发明涉及一种用于从液体进料选择性溶剂蒸发的装置和装置，所述进料包含在至少第一溶剂或溶剂共混物中稀释的一种或多种组分，所述组分包括：a）第一管状容器，其具有远端 或适于在管状容器的尖端或内腔中以流入速率n形成第一体积的液滴的通道，以及b）用于使液滴以蒸发速率进行溶剂去除步骤的装置 r2蒸发至少部分第一溶剂或溶剂共混物，以在堆积速率r3的蒸发过程中将液体中的组分积聚在液滴中，以获得浓缩液滴中的浓缩进料体积，其中蒸发和/ 或流入速率连续调整以达到所需的累积率。 本发明还涉及从色谱分离过程中获得的分析物混合物中选择性溶剂去除的方法。
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公开(公告)号：US09625427B2
公开(公告)日：2017-04-18
申请号：US14384943
申请日：2013-03-12
Applicant: UNIVERSITEIT LEIDEN
Inventor： Thomas Hankemeier , Jan-Willem Schoonen , Heiko Jan Van Der Linden , Paul Vulto
CPC classification number: G01N30/12 , B01D1/00 , G01N1/2214 , G01N1/2273 , G01N1/24 , G01N1/4022 , G01N1/405 , G01N30/463 , G01N30/62 , G01N2001/2223 , G01N2001/4027 , G01N2030/027 , G01N2030/126
Abstract: The present invention relates to a device and an arrangement for selective solvent evaporation from a liquid feed, the feed comprising one or more components diluted in at least a first solvent or a solvent blend, comprising: a) a first tubular vessel having a distal end or a channel suitable for the formation of a droplet of a first volume, at an inflow rate n, at the tip or in the lumen of the tubular vessel, and b) means for subjecting the droplet to a solvent removal step at an evaporation rate r2 to evaporate at least part of the first solvent or solvent blend, to accumulate the components in the feed in the droplet during the evaporation process at an accumulation rate r3, to obtain a concentrated feed volume in a concentrated droplet, wherein the evaporation and/or inflow rates are continuously adjusted to achieve a desired accumulation rate. The invention further relates to a method for selective solvent removal from an analyte mixture obtained in a chromatographic separation process.
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