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    Apparatuses for and methods of processing cells and related structures
    1.
    发明授权
    Apparatuses for and methods of processing cells and related structures 有权

    公开(公告)号：US10900008B2

    公开(公告)日：2021-01-26

    申请号：US16571552

    申请日：2019-09-16

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Heiko Jan van der Linden ,  Adrianus Theodoras Joore ,  Thomas Hankemeier

    IPC: C12M1/00 ,  B01F13/00 ,  B01L3/00 ,  C12M3/06 ,  C12M1/42

    Abstract: Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume (10) that (a) is internally divided into at least first (14), second (16) and third (17) sub-volumes by at least two phaseguides (12, 13) formed inside the volume and (b) includes parts that are relatively upstream and relatively downstream when judged with reference to the movement of a meniscus or a bulk liquid in the volume (10). The apparatus includes at least first, second and third fluid conduits (19, 21, 22) connected to permit fluid communication between the upstream exterior of the volume (10) and a respective said sub-volume (14, 16, 17); and at least one further conduit (24) connected to permit fluid communication between the downstream exterior of the volume (10) and a said sub-volume. The first sub-volume (14) contains one or more life-based particles supported in or by a gel or gel-like substance; and the second sub-volume (16) communicates with the first sub-volume so as to permit transport of substances between the first and second sub-volumes (14, 16) and contains at least one gel or gel-like substance.

    METHOD AND DEVICE FOR SOLVENT EVAPORATION FROM A LIQUID FEED
    3.
    发明申请
    METHOD AND DEVICE FOR SOLVENT EVAPORATION FROM A LIQUID FEED 有权
    用于从液体进料的溶剂蒸发的方法和装置

    公开(公告)号：US20150075300A1

    公开(公告)日：2015-03-19

    申请号：US14384943

    申请日：2013-03-12

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Thomas Hankemeier ,  Jan-Willem Schoonen ,  Heiko Jan Van Der Linden ,  Paul Vulto

    IPC: G01N30/12 ,  G01N30/62 ,  G01N30/46

    CPC classification number: G01N30/12 ,  B01D1/00 ,  G01N1/2214 ,  G01N1/2273 ,  G01N1/24 ,  G01N1/4022 ,  G01N1/405 ,  G01N30/463 ,  G01N30/62 ,  G01N2001/2223 ,  G01N2001/4027 ,  G01N2030/027 ,  G01N2030/126

    Abstract: The present invention relates to a device and an arrangement for selective solvent evaporation from a liquid feed, the feed comprising one or more components diluted in at least a first solvent or a solvent blend, comprising: a) a first tubular vessel having a distal end or a channel suitable for the formation of a droplet of a first volume, at an inflow rate n, at the tip or in the lumen of the tubular vessel, and b) means for subjecting the droplet to a solvent removal step at an evaporation rate r2 to evaporate at least part of the first solvent or solvent blend, to accumulate the components in the feed in the droplet during the evaporation process at an accumulation rate r3, to obtain a concentrated feed volume in a concentrated droplet, wherein the evaporation and/or inflow rates are continuously adjusted to achieve a desired accumulation rate. The invention further relates to a method for selective solvent removal from an analyte mixture obtained in a chromatographic separation process.

    Abstract translation: 本发明涉及一种用于从液体进料选择性溶剂蒸发的装置和装置，所述进料包含在至少第一溶剂或溶剂共混物中稀释的一种或多种组分，所述组分包括：a）第一管状容器，其具有远端 或适于在管状容器的尖端或内腔中以流入速率n形成第一体积的液滴的通道，以及b）用于使液滴以蒸发速率进行溶剂去除步骤的装置 r2蒸发至少部分第一溶剂或溶剂共混物，以在堆积速率r3的蒸发过程中将液体中的组分积聚在液滴中，以获得浓缩液滴中的浓缩进料体积，其中蒸发和/ 或流入速率连续调整以达到所需的累积率。 本发明还涉及从色谱分离过程中获得的分析物混合物中选择性溶剂去除的方法。

    Two-phase electroextraction from moving phases
    5.
    发明授权
    Two-phase electroextraction from moving phases 有权

    公开(公告)号：US11504645B2

    公开(公告)日：2022-11-22

    申请号：US14898813

    申请日：2014-06-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Jan-Willem Schoonen ,  Peter Lindenburg ,  Vincent Van Duinen ,  Amar Oedit ,  Paul Vulto ,  Thomas Hankemeier

    IPC: B01D11/04 ,  G01N1/40 ,  B01L3/00

    Abstract: The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode; and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode.

    Fluid triggerable valves
    8.
    发明授权
    Fluid triggerable valves 有权
    流体触发阀

    公开(公告)号：US09429249B2

    公开(公告)日：2016-08-30

    申请号：US14465345

    申请日：2014-08-21

    Applicant: Universiteit Leiden

    Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Ender Yildirim

    IPC: B01L99/00 ,  F16K99/00 ,  B01L3/00

    CPC classification number: F16K99/0026 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2400/0406 ,  B01L2400/0688 ,  F16K2099/0084 ,  Y10T137/7859

    Abstract: The present invention relates to a fluid triggerable passive valve for controlling flow of one or more fluids comprising: a volume comprising at least two capillary pressure barriers for respectively pinning a first and second fluid-fluid meniscus, the two capillary pressure barriers dividing the volume in at least three sub volumes, whereby two sub volumes being positioned upstream and one sub volume being positioned downstream with respect to the advancement direction of each respective fluid-fluid meniscus; wherein the capillary pressure barriers are spaced apart such that upon pinning of a first fluid-fluid meniscus on a first capillary pressure barrier and arrival or pinning of a second fluid-fluid meniscus on or at a second capillary pressure barrier, the two menisci touch and thereby coalesce into one fluid-fluid meniscus.

    Abstract translation: 本发明涉及一种用于控制一种或多种流体流动的流体可触发的被动阀，包括：一个体积，包括至少两个用于分别固定第一和第二流体 - 液体弯液面的毛细管压力屏障，两个毛细管压力屏障将体积分成 至少三个子体积，其中两个子体积位于上游，一个子体积相对于每个相应的流体 - 液体弯液面的前进方向位于下游; 其中所述毛细管压力屏障间隔开，使得当在第一毛细管压力屏障上锁定第一流体 - 液体弯液面并且在第二毛细管压力屏障上或在第二毛细管压力屏障上到达或钉住第二流体 - 液体弯月面时，两个半月板触摸和 从而聚结成一个流体 - 液体弯液面。

    Capillary pressure barriers
    9.
    发明授权
    Capillary pressure barriers 有权

    公开(公告)号：US11344877B2

    公开(公告)日：2022-05-31

    申请号：US14426920

    申请日：2013-09-10

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Ender Yildirim

    IPC: B01L3/00

    Abstract: The present invention relates to an apparatus for controlling the shape and/or position of a moveable fluid-fluid meniscus, and methods of use, in particular a method to control the shape of a moveable fluid-fluid meniscus in an apparatus in which the meniscus is caused to align along a stable capillary barrier or phaseguide.

    APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES
    10.
    发明申请
    APPARATUSES FOR AND METHODS OF PROCESSING CELLS AND RELATED STRUCTURES 审中-公开

    公开(公告)号：US20200071650A1

    公开(公告)日：2020-03-05

    申请号：US16571552

    申请日：2019-09-16

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Paul Vulto ,  Sebastiaan Johannes Trietsch ,  Heiko Jan van der Linden ,  Adrianus Theodorus Joore ,  Thomas Hankemeier

    IPC: C12M1/00 ,  B01L3/00 ,  C12M1/42 ,  C12M3/06 ,  B01F13/00

    Abstract: Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume (10) that (a) is internally divided into at least first (14), second (16) and third (17) sub-volumes by at least two phaseguides (12, 13) formed inside the volume and (b) includes parts that are relatively upstream and relatively downstream when judged with reference to the movement of a meniscus or a bulk liquid in the volume (10). The apparatus includes at least first, second and third fluid conduits (19, 21, 22) connected to permit fluid communication between the upstream exterior of the volume (10) and a respective said sub-volume (14, 16, 17); and at least one further conduit (24) connected to permit fluid communication between the downstream exterior of the volume (10) and a said sub-volume. The first sub-volume (14) contains one or more life-based particles supported in or by a gel or gel-like substance; and the second sub-volume (16) communicates with the first sub-volume so as to permit transport of substances between the first and second sub-volumes (14, 16) and contains at least one gel or gel-like substance.

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