摘要:
The invention relates to compounds of formula (I), wherein R, R1, R2, X and n are as defined in the description, and their use for the preparation of pharmaceutical compositions for the treatment of inflammatory states.
摘要:
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
摘要:
The invention provides N,N′-disubstituted monothiourea or bis-thiourea-Pd(0) complexes that are useful as catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins, and as catalysts for palladium catalyzed Suzuki reactions of organoboric compounds and aryl halides.
摘要:
The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such compounds for the treatment of disease states in which glycine is involved.
摘要:
The instant invention is new compounds of Formula I ##STR1## their use as cerebrovascular agents in diseases such as stroke, peripheral vascular disease, restenosis, and as agents for regulating plasma cholesterol concentrations, for treating hypercholesterolemia and atherosclerosis, and for lowering the serum or plasma level of Lp(a). A pharmaceutical composition is also claimed.
摘要:
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
摘要:
##STR1## A very mild and efficient approach for the synthesis of ureas is described. Phenyl carbamates were used as intermediates for the preparation of N,N'- substituted ureas. The carbamates were treated with an approximate stoichiometric amount of amine in dimethyl sulfoxide at ambient temperature, generating the ureas in high yield. The reaction was simple, safe, fast, inexpensive, and amenable to large scale production of the product.
摘要:
Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
摘要:
A thermal recording sheet wherein a compound of Formula (I) or (II) is contained in a thermal color developing layer including a basic colorless dye and an organic color developer as main ingredients: ##STR1## (wherein A denotes hydrogen atom, an alkyl group of C.sub.1 to C.sub.4, an alkoxy group of C.sub.1 to C.sub.4, hydroxy group, or nitro group. R.sub.1, R.sub.2, and R.sub.3 are hydrogen atom, an alkyl group of C.sub.1 to C.sub.4, an alkoxy group of C.sub.1 to C.sub.4, hydroxy group, or nitro group. R.sub.1 and R.sub.2 may combine with each other to form an aromatic ring. Y is sulfur or oxygen atom.), ##STR2## (wherein B denotes hydrogen atom, an alkyl group of C.sub.1 to C.sub.4, an alkoxy group of C.sub.1 to C.sub.4, hydroxy group, or nitro group. R.sub.1, R.sub.2, and R.sub.3 are hydrogen atom, an alkyl group of C.sub.1 to C.sub.4, an alkoxy group of C.sub.1 to C.sub.4, hydroxy group, or nitro group. R.sub.1 and R.sub.2 may combine with each other to form an aromatic ring. Y is sulfur or oxygen atom.).The thermal recording sheet has a high sensitivity and high image stability.
摘要:
The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.