WATER-SOLUBLE TRITERPENEPHENOL COMPOUNDS HAVING ANTITUMOR ACTIVITY AND THE PREPARATION THEREOF
    20.
    发明申请
    WATER-SOLUBLE TRITERPENEPHENOL COMPOUNDS HAVING ANTITUMOR ACTIVITY AND THE PREPARATION THEREOF 有权
    具有抗肿瘤活性的水溶性三羟甲基苯酚化合物及其制备方法

    公开(公告)号:US20100267983A1

    公开(公告)日:2010-10-21

    申请号:US12743101

    申请日:2008-11-05

    IPC分类号: C07C309/60 C07C69/753

    CPC分类号: C07J63/00 C07J63/008

    摘要: The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.

    摘要翻译: 本发明公开了具有由式(I)表示的抗肿瘤活性的水溶性三硝基苯酚化合物,其中取代基R 1〜R 4和M如说明书中所定义。 本发明还公开了使用醌甲基化三萜化合物作为原料制备式(I)化合物的方法。 本发明公开的水溶性三萜烯化合物可以制成各种剂型,包括注射剂,片剂,胶囊剂,颗粒剂和搽剂,特别适用于注射。