公开(公告)号：US11857566B2

公开(公告)日：2024-01-02

申请号：US17298777

申请日：2019-12-03

申请人： UNIWERSYTET JAGIELLONSKI

发明人： Aleksandra Synowiec ,  Magdalena Pachota ,  Krzysztof Pyrc ,  Maria Nowakowska ,  Krzysztof Szczubialka

IPC分类号： A61K31/795 ,  A61P31/22 ,  A61P31/14 ,  A61K45/06

CPC分类号： A61K31/795 ,  A61K45/06 ,  A61P31/14 ,  A61P31/22

摘要： The present invention relates to a sulfonated polystyrene derivative of formula I for use in the treatment and/or prophylaxis of cat flu, especially infection caused by feline calicivirus or feline herpesvirus, alone or in combination therapy.

公开(公告)号：US11723916B2

公开(公告)日：2023-08-15

申请号：US17341912

申请日：2021-06-08

申请人： CytoSorbents Corporation

发明人： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC分类号： A61K31/795 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61K47/20 ,  A61K47/26 ,  A61M1/36 ,  A61M5/14

CPC分类号： A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28069 ,  B01J39/20 ,  A61M1/3679 ,  A61M5/14

摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US20230157988A1

公开(公告)日：2023-05-25

申请号：US17992275

申请日：2022-11-22

申请人： Pykus Therapeutics, Inc.

发明人： Laurence A. ROTH ,  Charles SIDOTI ,  James Anthony STEFATER, III ,  Tomasz Pawel STRYJEWSKI

IPC分类号： A61K31/25 ,  A61K31/795 ,  A61K9/00 ,  A61K9/06 ,  A61K47/54

CPC分类号： A61K31/25 ,  A61K31/795 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/548

摘要： Provided are formulations, methods, and devices for providing a hydrogel. The formulations and resulting hydrogels may be used for treating various disorders, including ocular disorders. In certain embodiments, the hydrogel is formed from formulations comprising (a) a nucleo-functional polymer that is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer; (b) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups; and (c) one or more pharmaceutically active agents. In certain embodiments, the hydrogel is formed at a targeted sited using methods and/or devices for focal administration of the formulations and/or hydrogels described herein.

公开(公告)号：US20190216744A1

公开(公告)日：2019-07-18

申请号：US16327898

申请日：2017-08-25

申请人： Yoshiko Miura ,  Yu Hoshino ,  Yuri Nishimura ,  Naoto Oku ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Kenneth J. Shea ,  Hiroyuki Koide ,  Yoshiko Miura ,  Yu Hoshino ,  Yuri Nishimura ,  Naoto Oku

IPC分类号： A61K9/51 ,  A61K31/795 ,  A61P35/00 ,  A61K31/785 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/0019 ,  A61K31/704 ,  A61K31/785 ,  A61K31/795 ,  A61P35/00

摘要： The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer.

公开(公告)号：US20180362462A1

公开(公告)日：2018-12-20

申请号：US15838751

申请日：2017-12-12

申请人： THE BOEING COMPANY

发明人： Michael MONTEIRO ,  Jason W. ARMSTRONG

IPC分类号： C07D207/416 ,  A61K31/4015 ,  A61K31/4402 ,  A61K31/4188

CPC分类号： C07D207/416 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/4402 ,  A61K31/795 ,  C08F220/54 ,  C08F293/005 ,  C08F299/00 ,  C08F2438/03 ,  A61K2300/00 ,  C08F212/08

摘要： The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

公开(公告)号：US20180214478A1

公开(公告)日：2018-08-02

申请号：US15887561

申请日：2018-02-02

申请人： University of British Columbia

发明人： Jayachandran N. Kizhakkedathu ,  Rajesh A. Shenoi ,  Cedric J. Carter ,  Donald E. Brooks

IPC分类号： A61K31/795 ,  A61K9/06 ,  A61K31/765 ,  A61K31/785 ,  B01D15/36 ,  A61K47/34 ,  C08G73/02 ,  A61K9/00 ,  A61M1/36 ,  C08L71/02

CPC分类号： A61K31/795 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/765 ,  A61K31/785 ,  A61K47/34 ,  A61M1/3675 ,  A61M1/3679 ,  A61M2202/0021 ,  A61M2202/0413 ,  A61M2202/0478 ,  B01D15/36 ,  C08G73/024 ,  C08G2340/00 ,  C08L71/02

摘要： Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

公开(公告)号：US09950103B2

公开(公告)日：2018-04-24

申请号：US15060405

申请日：2016-03-03

申请人： Micromedics Inc.

发明人： Saeid Mordechai Nosrati

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61K38/38 ,  A61K33/44 ,  A61K31/795

CPC分类号： A61M1/1633 ,  A61K31/795 ,  A61K33/44 ,  A61K38/38 ,  A61M1/1654 ,  A61M1/1676 ,  A61M1/1698 ,  A61M1/3413 ,  A61M1/3417 ,  A61M1/3431 ,  A61M1/3479 ,  A61M1/3482 ,  A61M1/3496 ,  A61M2202/07 ,  A61M2202/08

摘要： A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.

公开(公告)号：US09925270B2

公开(公告)日：2018-03-27

申请号：US14361167

申请日：2012-11-28

申请人： The Regents of the University of California

发明人： Heather D. Maynard ,  Thi Nguyen

IPC分类号： A61K47/48 ,  A61K38/18 ,  A61K31/795

CPC分类号： A61K38/1825 ,  A61K31/78 ,  A61K31/795 ,  A61K47/32 ,  A61K47/58 ,  C07K14/503 ,  C08F212/14 ,  C08F220/28 ,  C08F2220/286 ,  Y02A50/385 ,  Y02A50/411

摘要： A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.

公开(公告)号：US20180079865A1

公开(公告)日：2018-03-22

申请号：US15829248

申请日：2017-12-01

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Dong-Chul Pyun ,  Nicholas George Pavlopoulos

IPC分类号： C08G75/16 ,  C08J3/28 ,  A01N59/02 ,  A61K31/795 ,  C01B3/04 ,  C01B17/96 ,  H01M4/60 ,  C08L81/04 ,  A01N41/12 ,  C08G75/14 ,  H01M4/38 ,  H01M10/052

CPC分类号： C08G75/16 ,  A01N41/12 ,  A01N59/02 ,  A61K31/795 ,  C01B3/042 ,  C01B17/96 ,  C08G75/14 ,  C08J3/28 ,  C08J2381/04 ,  C08L81/04 ,  C08L2201/52 ,  H01M4/364 ,  H01M4/38 ,  H01M4/382 ,  H01M4/5815 ,  H01M4/606 ,  H01M4/62 ,  H01M10/052 ,  Y02T10/7011

摘要： Compositions and methods of producing composite materials for use as a cathode in electrochemical cells. Elemental sulfur is mixed with tungsten sulfide (WS2) to form a composite mixture. Organic comonomers may be added to the composite mixture. The composite mixture is reacted to form the composite material. Electrochemical cells with cathodes containing the composite material demonstrated improved battery performance.

公开(公告)号：US09801845B2

公开(公告)日：2017-10-31

申请号：US15196420

申请日：2016-06-29

申请人： Novus International Inc.

发明人： Graciela B. Arhancet ,  Matthew Mahoney ,  Scott Long ,  Mariya Grega ,  Drew L. Lichtenstein ,  Vivek Kuttappan ,  Jeffery Escobar Monestel ,  Mercedes Vazquez-Anon

IPC分类号： A61K31/795 ,  A61K31/23 ,  A61K31/225 ,  A23K20/105 ,  A01N41/00 ,  A01N55/00 ,  A23K10/18 ,  A23K20/174 ,  A23K20/111 ,  A23K20/142 ,  A23K20/158 ,  A23K20/163 ,  A23K20/10 ,  A23K20/189 ,  A23K20/195 ,  A23K20/28 ,  A23K20/20 ,  A23K50/10 ,  A23K50/75 ,  A23K50/30 ,  A23K50/40 ,  A23K50/80 ,  A23K30/00 ,  A61K45/06 ,  A61K31/80

CPC分类号： A61K31/23 ,  A01N41/00 ,  A01N55/00 ,  A23K10/18 ,  A23K20/10 ,  A23K20/105 ,  A23K20/111 ,  A23K20/142 ,  A23K20/158 ,  A23K20/163 ,  A23K20/174 ,  A23K20/189 ,  A23K20/195 ,  A23K20/28 ,  A23K20/30 ,  A23K30/00 ,  A23K50/10 ,  A23K50/30 ,  A23K50/40 ,  A23K50/75 ,  A23K50/80 ,  A61K31/225 ,  A61K31/795 ,  A61K31/80 ,  A61K45/06 ,  A01N2300/00 ,  A61K2300/00

摘要： Antimicrobial compositions comprising sulfur- or selenium-containing, fatty-acylated alpha-hydroxy acid compounds and methods of using said compounds or compositions to inhibit microbial growth.