公开(公告)号：US20230293576A1

公开(公告)日：2023-09-21

申请号：US17926847

申请日：2021-05-21

申请人： The University of Manchester

发明人： Samuel Thomas Jones

IPC分类号： A61K31/795 ,  A01N31/08 ,  A01P1/00 ,  A61P31/12 ,  C08F120/38 ,  C08F112/14

CPC分类号： A61K31/795 ,  A01N31/08 ,  A01P1/00 ,  A61P31/12 ,  C08F112/30 ,  C08F120/38 ,  C08F2438/01

摘要： The present invention relates to polymer compounds that have antiviral activity. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to compositions comprising them, and to their use in the prevention or treatment of viral infections.

公开(公告)号：US11685715B2

公开(公告)日：2023-06-27

申请号：US17526596

申请日：2021-11-15

申请人： THE BOEING COMPANY

发明人： Michael Monteiro ,  Jason W. Armstrong

IPC分类号： C07D207/416 ,  A61K31/4188 ,  A61K31/4402 ,  A61K31/4015 ,  C08F293/00 ,  C08F299/00 ,  A61K31/795 ,  C08F220/54

CPC分类号： C07D207/416 ,  A61K31/4015 ,  A61K31/4188 ,  A61K31/4402 ,  A61K31/795 ,  C08F293/005 ,  C08F299/00 ,  C08F220/54 ,  C08F2438/03 ,  A61K31/795 ,  A61K2300/00 ,  C08F220/54 ,  C08F212/08

摘要： The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I):




or a pharmaceutically acceptable salt thereof, wherein:
Q is fluoro, chloro, bromo, or iodo;
each of s, b, and n is independently an integer from about 10 to about 100; and
each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

公开(公告)号：US20230124390A1

公开(公告)日：2023-04-20

申请号：US18079891

申请日：2022-12-13

申请人： SOUTH CHINA UNIVERSITY OF TECHNOLOGY ,  SUN YAT-SEN MEMORIAL HOSPITAL, SUN YAT-SEN UNIVERSITY

发明人： Menghua XIONG ,  Yan BAO ,  Liangqi HUANG ,  Xiaochuan WANG ,  Mingdong LIU ,  Yangbin LIANG ,  Jun WANG

IPC分类号： C08L41/00 ,  A61K31/795 ,  A61K9/51 ,  A61P31/04 ,  A61P35/00

摘要： The present disclosure provides a pH-sensitive membranolytic polymer material and a preparation method and application thereof. The pH-sensitive membranolytic polymer material has the structure shown in Formula (I). At normal physiological pH, the polymer material is hydrophobic neutral, and can be self-assembled into PEG coated nanoparticles with weak interaction with cell membrane; when the pH decreases, the polymer material can be protonated to form an amphiphilic structure consisting of hydrophobic domain and cationic domain, which has strong interaction with the cell membrane and strong membranolytic activity, so the polymer material can kill tumor cells or bacteria efficiently and selectively.

公开(公告)号：US20230122378A1

公开(公告)日：2023-04-20

申请号：US17494708

申请日：2021-10-05

申请人： International Business Machines Corporation ,  Agency for Science, Technology and Research

发明人： James L. Hedrick ,  Yi Yan Yang ,  Agnes Mari Kuroki ,  Jiayu Eunice Leong ,  Wei Ping Eddy Tan

IPC分类号： A61K31/795 ,  C08G64/02 ,  A61P31/14

摘要： A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

公开(公告)号：US11458107B2

公开(公告)日：2022-10-04

申请号：US16327898

申请日：2017-08-25

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Yoshiko Miura ,  Yu Hoshino ,  Yuri Nishimura ,  Naoto Oku

发明人： Kenneth J. Shea ,  Hiroyuki Koide ,  Yoshiko Miura ,  Yu Hoshino ,  Yuri Nishimura ,  Naoto Oku

IPC分类号： A61K9/51 ,  A61K31/795 ,  A61P35/00 ,  A61K31/785 ,  A61K31/704 ,  A61K9/00

摘要： The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer.

公开(公告)号：US20220175824A1

公开(公告)日：2022-06-09

申请号：US17298777

申请日：2019-12-03

申请人： UNIWERSYTET JAGIELLONSKI

发明人： Aleksandra SYNOWIEC ,  Magdalena PACHOTA ,  Krzysztof PYRC ,  Maria NOWAKOWSKA ,  Krzysztof SZCZUBIALKA

IPC分类号： A61K31/795 ,  A61K45/06 ,  A61P31/14 ,  A61P31/22

摘要： The present invention relates to a sulfonated polystyrene derivative of formula I for use in the treatment and/or prophylaxis of cat flu, especially infection caused by feline calicivirus or feline herpesvirus, alone or in combination therapy.

公开(公告)号：US20220073462A1

公开(公告)日：2022-03-10

申请号：US17526596

申请日：2021-11-15

申请人： THE BOEING COMPANY

发明人： Michael MONTEIRO ,  Jason W. Armstrong

IPC分类号： C07D207/416 ,  A61K31/4188 ,  A61K31/4402 ,  A61K31/4015 ,  C08F293/00 ,  C08F299/00 ,  A61K31/795

摘要： The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

公开(公告)号：US20210268016A1

公开(公告)日：2021-09-02

申请号：US17258357

申请日：2019-07-03

申请人： YALE UNIVERSITY

发明人： STEPHEN M. STRITTMATTER ,  Erik Christian GUNTHER ,  Levi M. SMITH

IPC分类号： A61K31/795 ,  A61K31/78 ,  A61K36/16 ,  A61K31/198 ,  A61K31/80 ,  A61K31/785 ,  A61K31/787 ,  A61K38/28 ,  A61K38/26 ,  A61K31/64 ,  A61K31/195 ,  A61K31/155 ,  A61K45/06 ,  A61P25/28

摘要： The disclosure provides polymeric compounds that inhibit binding of an amyloid-β-oligomer to cellular prion protein, methods for identifying such compounds, and their therapeutic use. In particular, the present disclosure provides a collection of anionic polymers and methods of using these compounds to treat amyloid-related disorders, e.g., Alzheimer's disease.

公开(公告)号：US20210236539A1

公开(公告)日：2021-08-05

申请号：US17229590

申请日：2021-04-13

申请人： Starpharma Pty Ltd

发明人： Jeremy Robert Arthur Paull ,  Jessica Huberman

IPC分类号： A61K31/795 ,  A61K9/00

摘要： Provided herein are methods for preventing transmission of Zika virus, and of preventing diseases, disorders and symptoms associated with Zika virus infections, in particular for preventing transmission during sexual intercourse. The methods comprise topical administration of a macromolecule comprising a dendrimer of 1 to 8 generations with one or more sulfonic acid- or sulfonate-containing moieties attached to one or more surface groups of the dendrimer. Also provided herein are related uses, compositions, devices and systems.

公开(公告)号：US11065272B2

公开(公告)日：2021-07-20

申请号：US15766314

申请日：2016-10-06

申请人： University of Washington

发明人： Patrick S. Stayton ,  Menko P. Ypma ,  Peter A. Chiarelli ,  Joshua Sang Hun Park ,  Richard G. Ellenbogen ,  Julia Mengyun Xu ,  Pierre D. Mourad ,  Donghoon Lee ,  Anthony Convertine ,  Forrest M. Kievit

IPC分类号： A61K31/765 ,  A61K47/30 ,  A61K9/14 ,  A61P25/28 ,  A61K9/00 ,  A61K9/51 ,  A61K31/795

摘要： Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.