公开(公告)号：US09977031B2

公开(公告)日：2018-05-22

申请号：US15348120

申请日：2016-11-10

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Philippe Goix ,  Robert Puskas ,  John Todd ,  Richard Livingston ,  Douglas Held ,  Allan H. B. Wu

IPC: G01N33/58 ,  G01N33/68 ,  G01N33/577

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

公开(公告)号：US20180106717A1

公开(公告)日：2018-04-19

申请号：US15715761

申请日：2017-09-26

Applicant: Government of the United States of America, as represented by the Secretary of Commerce

Inventor： SAMUEL MARTIN STAVIS ,  CRAIG ROBERT COPELAND

IPC: G01N21/31 ,  C12N15/10 ,  G02B21/36 ,  G01N1/30 ,  G01N21/64 ,  G01N21/89 ,  C12Q1/6825

CPC classification number: G01N21/314 ,  C12N15/1006 ,  C12Q1/68 ,  C12Q1/6825 ,  G01N1/30 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/8903 ,  G01N2021/174 ,  G01N2021/3129 ,  G01N2021/3196 ,  G01N2021/556 ,  G01N2021/558 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6491 ,  G01N2021/7756 ,  G01N2021/8883 ,  G01N2201/1247 ,  G02B21/361 ,  G02B21/367 ,  C12Q2525/204 ,  C12Q2563/107 ,  C12Q2565/601

Abstract: A process for measuring a size distribution of a plurality of nucleic acid molecules, the process comprising: labeling the nucleic acid molecules with a fluorescent dye comprising a plurality of fluorescent dye molecules to form labeled nucleic acid molecules, such that a number of fluorescent dyes molecules attached to each nucleic acid molecule is reliably proportional to the number of base pairs in the nucleic acid molecule, the fluorescent dye molecules having a first florescence spectrum; producing, by the labeled nucleic acid molecules, the first florescence spectrum in response to irradiating the labeled nucleic acid molecules at the first wavelength; and detecting the first florescence spectrum to measure the size distribution of the plurality of nucleic acid molecules.

公开(公告)号：US20170153248A1

公开(公告)日：2017-06-01

申请号：US15348120

申请日：2016-11-10

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Philippe Goix ,  Robert Puskas ,  John Todd ,  Richard Livingston ,  Douglas Held ,  Allan H.B. Wu

IPC: G01N33/68 ,  G01N33/577 ,  G01N33/58

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

公开(公告)号：US09562850B2

公开(公告)日：2017-02-07

申请号：US14648855

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain Oberti ,  Johan Fournel

IPC: G01N21/3577 ,  G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: A method for controlling a spectrometer for analyzing a product includes steps of: acquiring a measurement representative of the operation of a light source, determining, depending on the measurement, a value of supply current of the light source, and/or a value of integration time of light-sensitive cells of a sensor, disposed on a route of a light beam emitted by the light source and having interacted with a product to be analyzed, and if the integration time and/or supply current value is between threshold values, supplying the light source with a supply current corresponding to the determined supply current value, adjusting the integration time of a light-sensitive cell to the determined integration time value, and acquiring light intensity measurements supplied by the sensor, enabling a spectrum to be formed.

Abstract translation: 一种用于控制用于分析产品的光谱仪的方法包括以下步骤：获取代表光源的操作的测量，根据测量确定光源的电源电流的值和/或积分值 传感器的感光单元的时间设置在由光源发射的光束的路径上并且与待分析的产品相互作用，并且如果积分时间和/或电源电流值在阈值之间，则提供 所述光源具有与所确定的电源电流值相对应的电源电流，将感光单元的积分时间调整到所确定的积分时间值，以及获取由所述传感器提供的光强度测量值，从而能够形成光谱。

公开(公告)号：US07999232B2

公开(公告)日：2011-08-16

申请号：US12520687

申请日：2007-12-21

Applicant: Andrew Colin Wilson ,  Sri Kumar Sandeep ,  Reece Wim Geursen

Inventor： Andrew Colin Wilson ,  Sri Kumar Sandeep ,  Reece Wim Geursen

IPC: G01N21/35

CPC classification number: G01N21/3504 ,  G01J3/4338 ,  G01N21/031 ,  G01N21/39 ,  G01N2021/3148 ,  G01N2021/399 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/06146 ,  G01N2201/0694 ,  G01N2201/1211 ,  G01N2201/1247

Abstract: A gas detector (10) that is arranged to sense the concentration levels of target gases oxygen, methane, carbon monoxide, and hydrogen sulphide, within a gas sample from an environment surrounding the detector. The gas detector (10) comprises laser sources (12a-12d) that are arranged to transmit radiation through the gas sample at four target wavelengths that correspond approximately to the optimum absorption wavelengths of each of the target gases and an optical detector (16) that is arranged to sense the intensity of the radiation transmitted through the gas sample at each of the target wavelengths. A control system (22) generates representative concentration level information for the target gases based on the level of absorption of the radiation transmitted.

Abstract translation: 一种气体检测器（10），其被布置成感测来自环境周围环境的气体样品中的目标气体氧气，甲烷，一氧化碳和硫化氢的浓度水平。 气体检测器（10）包括激光源（12a-12d），其被布置成以四个目标波长透射通过气体样品的辐射，其大致对应于每个目标气体的最佳吸收波长;以及光学检测器（16）， 布置成感测在每个目标波长处透射通过气体样品的辐射的强度。 控制系统（22）基于所发射的辐射的吸收水平产生目标气体的代表性浓度水平信息。

公开(公告)号：US20100255518A1

公开(公告)日：2010-10-07

申请号：US11784213

申请日：2007-04-04

Applicant: Philippe J. Goix ,  Robert Puskas ,  John Todd ,  Richard A. Livingston ,  Douglas Held

Inventor： Philippe J. Goix ,  Robert Puskas ,  John Todd ,  Richard A. Livingston ,  Douglas Held

IPC: G01N33/543 ,  G01N33/68 ,  G01N33/53 ,  C12Q1/02 ,  C12Q1/48 ,  C12Q1/32 ,  C12Q1/52 ,  C07K16/00 ,  G01N31/00 ,  B01L3/00

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。

公开(公告)号：US09921169B2

公开(公告)日：2018-03-20

申请号：US15159266

申请日：2016-05-19

Applicant: Zeta Instruments, Inc.

Inventor： Steven W. Meeks ,  Rusmin Kudinar ,  Ronny Soetarman ,  Hung P. Nguyen

IPC: G01N21/55 ,  G01N21/958 ,  G01N21/94

CPC classification number: G01N21/958 ,  G01L1/00 ,  G01N21/21 ,  G01N21/55 ,  G01N21/8806 ,  G01N21/94 ,  G01N2021/8854 ,  G01N2201/06113 ,  G01N2201/0683 ,  G01N2201/105 ,  G01N2201/1247

Abstract: A method for detecting defects includes directing a scanning beam to a location on a surface of a transparent sample, measuring top and bottom surface specular reflection intensity, and storing coordinate values of the first location and the top and bottom surface specular reflection intensity in a memory. The method may further include comparing the top surface specular reflection intensity measured at each location with a first threshold value, comparing the bottom surface specular reflection intensity measured at each location with a second threshold value, and determining if a defect is present at each location and on which surface the defect is present. The method may further include comparing the top surface specular reflection intensity measured at each location with a first intensity range, comparing the bottom surface specular reflection intensity measured at each location with a second intensity range, and determining on which surface the defect is present.

公开(公告)号：US09494598B2

公开(公告)日：2016-11-15

申请号：US13795554

申请日：2013-03-12

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Philippe Goix ,  Robert Puskas ,  John Todd ,  Richard Livingston ,  Douglas Held ,  Allan H. B. Wu

IPC: G01N33/00 ,  G01N33/68 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。

公开(公告)号：US20150300951A1

公开(公告)日：2015-10-22

申请号：US14648874

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain OBERTI ,  Johan FOURNEL

IPC: G01N21/3577 ,  G01N21/27

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.

Abstract translation: 本发明涉及一种用于分析产品的光谱仪的控制方法，该光谱仪包括具有多个发光二极管的光源，该发光二极管具有组合分析波长带的各发射光谱，该方法包括以下步骤：将至少一个 的发光二极管与供电电流接通，通过测量至少另一个发光二极管的端子上的电流来测量由光源发射的光强度，根据每个光 强度测量，导通的每个二极管的电源电流的设定值，以及调节导通的每个二极管的电源电流，使其对应于设定值。

公开(公告)号：US20100140478A1

公开(公告)日：2010-06-10

申请号：US12520687

申请日：2007-12-21

Applicant: Andrew Colin Wilson ,  Sri Kumar Sandeep ,  Reece Wim Geursen

Inventor： Andrew Colin Wilson ,  Sri Kumar Sandeep ,  Reece Wim Geursen

IPC: G01N21/35

CPC classification number: G01N21/3504 ,  G01J3/4338 ,  G01N21/031 ,  G01N21/39 ,  G01N2021/3148 ,  G01N2021/399 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/06146 ,  G01N2201/0694 ,  G01N2201/1211 ,  G01N2201/1247

Abstract: A gas detector (10) that is arranged to sense the concentration levels of target gases oxygen, methane, carbon monox-ide, and hydrogen sulphide, within a gas sample from an environment surrounding the detector. The gas detector (10) comprises laser sources (12a-12d) that are arranged to transmit radiation through the gas sample at four target wavelengths that correspond approximately to the optimum absorption wavelengths of each of the target gases and an optical detector (16) that is arranged to sense the intensity of the radiation transmitted through the gas sample at each of the target wavelengths. A control system (22) generates representative concentration level information for the target gases based on the level of absorption of the radiation transmitted.

Abstract translation: 气体检测器（10），其布置成感测来自环境中的环境中的气体样品中的目标气体氧气，甲烷，一氧化碳和硫化氢的浓度水平。 气体检测器（10）包括激光源（12a-12d），其被布置成以四个目标波长透射通过气体样品的辐射，其大致对应于每个目标气体的最佳吸收波长;以及光学检测器（16）， 布置成感测在每个目标波长处透射通过气体样品的辐射的强度。 控制系统（22）基于所发射的辐射的吸收水平产生目标气体的代表性浓度水平信息。