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公开(公告)号：US20200347006A1
公开(公告)日：2020-11-05
申请号：US16880146
申请日：2020-05-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US10703706B2
公开(公告)日：2020-07-07
申请号：US16270965
申请日：2019-02-08
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20200095186A1
公开(公告)日：2020-03-26
申请号：US16580828
申请日：2019-09-24
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/732 , C07C69/013 , C07C69/26 , C07C69/675 , C07C69/708 , C07C69/712 , C07C69/96 , C07D303/48 , A61K9/00 , A61K9/70 , A61K31/216 , A61K45/06
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09505737B2
公开(公告)日：2016-11-29
申请号：US14333456
申请日：2014-07-16
申请人： Corsair Pharma, Inc.
发明人： Cyrus K. Becker , Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号： C07D317/40 , C07D453/02 , C07D257/06 , C07D321/00 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07C219/16 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
摘要翻译： 由式I，II，III和IV表示的化合物，包括前列环素和前列环素类似物的前药。 用途包括治疗肺动脉高压（PH）或肺动脉高压（PAH）。 化合物的结构可以适用于特定应用以获得合适的治疗剂量。 可以使用透皮应用。
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公开(公告)号：US11802105B2
公开(公告)日：2023-10-31
申请号：US17207975
申请日：2021-03-22
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/675 , C07C69/68 , C07D305/08 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20230331691A1
公开(公告)日：2023-10-19
申请号：US17965914
申请日：2022-10-14
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US11505535B2
公开(公告)日：2022-11-22
申请号：US17214460
申请日：2021-03-26
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C59/72 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C69/74 , C07C69/96 , A61K9/70
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US20220112173A1
公开(公告)日：2022-04-14
申请号：US17214460
申请日：2021-03-26
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US10464877B2
公开(公告)日：2019-11-05
申请号：US15927636
申请日：2018-03-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/28 , C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09776982B2
公开(公告)日：2017-10-03
申请号：US15157574
申请日：2016-05-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D313/00 , A61K31/216 , C07C69/712 , C07D317/40 , C07D321/00 , C07D453/02 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/335 , C07C59/31
CPC分类号： C07D313/00 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31 , C07C59/54 , C07C69/712 , C07C69/734 , C07C219/16 , C07C235/20 , C07C235/34 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D321/00 , C07D453/02
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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