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公开(公告)号：US20180193077A1
公开(公告)日：2018-07-12
申请号：US15912038
申请日：2018-03-05
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/88 , B01F15/02 , B01F13/06 , B01F13/00 , B01F15/00 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8816 , A61B17/8805 , A61B2017/8838 , A61F2/28 , A61F2/30942 , A61F2/4601 , A61F2/4644 , A61F2002/2835 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2300/412 , A61L2430/02 , B01F13/0023 , B01F13/06 , B01F15/00506 , B01F15/0278
摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.
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公开(公告)号：US09913676B2
公开(公告)日：2018-03-13
申请号：US14941033
申请日：2015-11-13
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61F2/28 , A61B17/88 , A61F2/30 , A61L27/36 , A61L27/54 , B01F13/00 , B01F13/06 , B01F15/00 , B01F15/02 , A61F2/46
CPC分类号： A61B17/8816 , A61B17/8805 , A61B2017/8838 , A61F2/28 , A61F2/30942 , A61F2/4601 , A61F2/4644 , A61F2002/2835 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2300/412 , A61L2430/02 , B01F13/0023 , B01F13/06 , B01F15/00506 , B01F15/0278
摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.
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公开(公告)号：US20180044638A1
公开(公告)日：2018-02-15
申请号：US15232275
申请日：2016-08-09
CPC分类号： C12N5/0654 , A61F2/4644 , A61F2250/0067
摘要： A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.
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公开(公告)号：US20170304496A1
公开(公告)日：2017-10-26
申请号：US15643137
申请日：2017-07-06
IPC分类号： A61L27/36 , C08G18/38 , A61L27/46 , A61L27/54 , A61L27/58 , C08G18/10 , C08G18/77 , C08G18/73 , C08G18/64 , A61L27/18 , C08L75/04 , C08G18/79
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US09271844B2
公开(公告)日：2016-03-01
申请号：US13801170
申请日：2013-03-13
发明人： Julien J. Prevost , Charles Britt , Kyle Hess , David R. Kaes , Kelly W. Schlachter , Guobao Wei
CPC分类号： A61F2/4465 , A61F2/44 , A61F2/4455 , A61F2002/2835 , A61F2002/30062 , A61F2002/30092 , A61F2002/30235 , A61F2002/30405 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30593 , A61F2002/30601 , A61F2002/30733 , A61F2002/30841 , A61F2002/4475
摘要： A spinal implant comprises a first member including a wall that defines a first cavity and a second member including a wall defining a second cavity. At least one first expandable bone graft is disposable within the second cavity. The second member is axially translatable relative to the first member between a first configuration and a second, expanded configuration such that at least a portion of the at least one first graft is disposed within the first cavity and the first cavity includes a substantially void portion. At least one second bone graft has a selective configuration and dimension for disposal within the substantially void portion. Systems and methods are disclosed.
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公开(公告)号：US11903627B2
公开(公告)日：2024-02-20
申请号：US16879347
申请日：2020-05-20
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/00 , A61B17/88 , A61F2/46 , B01F33/70 , B01F33/501 , B01F35/32 , B01F35/75 , A61J1/20 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8816 , A61B17/8805 , A61F2/28 , A61F2/30942 , A61F2/4644 , A61J1/20 , A61L27/365 , A61L27/3608 , A61L27/3683 , A61L27/3691 , A61L27/54 , B01F33/50112 , B01F33/70 , B01F35/3202 , B01F35/75425 , A61B2017/8838 , A61F2/4601 , A61F2002/2835 , A61L2300/412 , A61L2430/02
摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.
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公开(公告)号：US10080661B2
公开(公告)日：2018-09-25
申请号：US15149920
申请日：2016-05-09
发明人： Deger C. Tunc , John Winterbottom , David R. Kaes , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
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公开(公告)号：US09480575B2
公开(公告)日：2016-11-01
申请号：US15005157
申请日：2016-01-25
发明人： Julien J. Prevost , Charles A. Britt , Kyle A. Hess , David R. Kaes , Kelly W. Schlachter , Guobao Wei
CPC分类号： A61F2/4465 , A61F2/44 , A61F2/4455 , A61F2002/2835 , A61F2002/30062 , A61F2002/30092 , A61F2002/30235 , A61F2002/30405 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30593 , A61F2002/30601 , A61F2002/30733 , A61F2002/30841 , A61F2002/4475
摘要： A spinal implant comprises a first member including a wall that defines a first cavity and a second member including a wall defining a second cavity. At least one first expandable bone graft is disposable within the second cavity. The second member is axially translatable relative to the first member between a first configuration and a second, expanded configuration such that at least a portion of the at least one first graft is disposed within the first cavity and the first cavity includes a substantially void portion. At least one second bone graft has a selective configuration and dimension for disposal within the substantially void portion. Systems and methods are disclosed.
摘要翻译： 脊柱植入物包括第一构件，其包括限定第一空腔的壁和包括限定第二空腔的壁的第二构件。 至少一个第一可膨胀骨移植物在第二腔内是一次性的。 第二构件相对于第一构件在第一构造和第二膨胀构造之间可轴向平移，使得至少一个第一移植物的至少一部分设置在第一空腔内，并且第一空腔包括基本上空隙部分。 至少一个第二骨移植物具有用于在基本上无空隙部分内处置的选择性构型和尺寸。 公开了系统和方法。
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公开(公告)号：US09333080B2
公开(公告)日：2016-05-10
申请号：US13972640
申请日：2013-08-21
发明人： Deger C. Tunc , John Winterbottom , David R. Kaes , Todd M. Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
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公开(公告)号：US09327052B2
公开(公告)日：2016-05-03
申请号：US13867689
申请日：2013-04-22
IPC分类号： A61K31/74 , A61F13/00 , A61L27/18 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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