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公开(公告)号：US20230219080A1
公开(公告)日：2023-07-13
申请号：US17573311
申请日：2022-01-11
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Ralf Lenigk , Tejas Suresh Khire , Tyler Hammond , Erik Leeming Kvam , Allison Caron
IPC: B01L3/00
CPC classification number: B01L3/5021 , B01L3/502715 , B01L2300/087 , B01L2200/10
Abstract: A closed system centrifuge tube is described and discussed herein that enables removal of waste and transfer and removal of samples via one or more ports of the centrifuge tube within the closed system, without exposing the sample to the outer environment. This may enable greater sample retention during sample processing and centrifugation of the sample.
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公开(公告)号：US20220175306A1
公开(公告)日：2022-06-09
申请号：US17437731
申请日：2020-03-12
Applicant: General Electric Company
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
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公开(公告)号：US11318330B2
公开(公告)日：2022-05-03
申请号：US16143255
申请日：2018-09-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
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公开(公告)号：US20210338805A1
公开(公告)日：2021-11-04
申请号：US17244642
申请日：2021-04-29
Applicant: General Electric Company
IPC: A61K39/215 , C12N15/86 , C12N13/00 , C07K14/54
Abstract: The subject matter of the present disclosure generally relates to techniques for addressing or correcting dysregulation of the trauma regulation pathway. The dysregulation may be associated with a physiological condition, such as a SARS-CoV-2 viral infection. In an embodiment, the techniques include treating dysregulation based on a renin-angiotensin pathway molecule or cell and/or a splenic pathway molecule or cell using targeted neuromodulation. In an embodiment, neuromodulation is used to regulate the immune system, e.g., as an energy-based adjuvant for a vaccine.
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公开(公告)号：US20210228912A1
公开(公告)日：2021-07-29
申请号：US16750932
申请日：2020-01-23
Applicant: General Electric Company
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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Patent Agency Ranking
公开(公告)号：US20210015454A1
公开(公告)日：2021-01-21
申请号：US16517289
申请日：2019-07-19
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , David Andrew Shoudy , Victoria Eugenia Cotero , James Enrico Sabatini
Abstract: Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.
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公开(公告)号：US20180160929A1
公开(公告)日：2018-06-14
申请号：US15377696
申请日：2016-12-13
Applicant: General Electric Company , Brigham Young University
Inventor： Jeffrey M. Ashe , Kaustubh Ravindra Nagarkar , Christopher Michael Puleo , Christopher Fred Keimel , Craig Patrick Galligan , Yizhen Lin , Nancy Cecelia Stoffel , Richard Vanfleet , Robert Davis , Guohai Chen
IPC: A61B5/0478 , A61B5/1473 , A61B5/145 , A61B5/11 , A61B7/02 , A61N1/05
CPC classification number: A61B5/0478 , A61B5/11 , A61B5/14546 , A61B5/1473 , A61B7/023 , A61B2017/0023 , A61B2017/00911 , A61B2562/0209 , A61B2562/0285 , A61B2562/06 , A61B2562/125 , A61N1/0531 , A61N1/0534
Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.
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公开(公告)号：US20170205404A1
公开(公告)日：2017-07-20
申请号：US15366520
申请日：2016-12-01
Applicant: GENERAL ELECTRIC COMPANY
IPC: G01N33/543 , G01N33/569
CPC classification number: G01N33/54326 , B01L3/00 , B01L3/50273 , B01L3/502753 , B01L2200/0668 , B01L2200/141 , B01L2300/0829 , B01L2300/0851 , B01L2400/043 , G01N33/505 , G01N33/54346 , G01N33/56972
Abstract: Described are multi-functional beads and methods to capture rare cells directly from low-volume biological samples and perform both functional and genomic assays from those cells. This is accomplished using a multifunctional capture bead that allows co-localization of both the single cell capture element and the molecular assay components. When combined with a digital microfluidic platform this enables encoding and/or barcoding of specific single cells.
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公开(公告)号：US09063041B2
公开(公告)日：2015-06-23
申请号：US13690801
申请日：2012-11-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk
CPC classification number: G01N1/30 , A01N1/0242 , A01N1/0284 , B01L3/5023 , B01L3/5088 , B01L7/00 , B01L2200/0678 , B01L2300/0825 , B01L2300/126 , B01L2300/1877 , G01N2001/4027 , Y10T436/2525
Abstract: A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
Abstract translation: 提供了一种干燥设置在基板上的生物样品的方法。 该方法包括提供包括样品加载区域和热源的基底; 激活热源产生热量; 将衬底加热至少高于65℃; 并干燥生物样品。 还提供了用于存储样品的装置，其中所述装置包括用于生物样品储存的基底; 以及产生热量以保持至少高于65℃的温度的加热组分。加热组分可以含有一种或多种试剂，其中试剂产生热量以保持至少高于65℃的温度。
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公开(公告)号：US20150165347A1
公开(公告)日：2015-06-18
申请号：US14563334
申请日：2014-12-08
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jason Michael Nichols , Christopher Michael Puleo , Jason Louis Davis , Daniel George Norton , Craig Patrick Galligan , Rachel Marie Gettings
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A microclarification system is disclosed which can be used to separate solid particulates dispersed within a base fluid such as water. The microclarification system includes a plurality of microfluidic separator units disposed between and in fluid communication with a fluid inlet manifold and a fluid outlet manifold. The microclarification system enforces lamellar flow of fluid though it and as a result the rate at which particles settle is enhanced within a collection chamber associated with each microfluidic separator unit and through which the fluid being purified must pass. Each microfluidic separator unit includes a microfluidic outlet microchannel disposed between the microfluidic collection chamber and the fluid outlet manifold, and a gas-liquid flushing module configured to purge particulates from the collection chamber during a collection chamber purge cycle. Optionally, each microfluidic separator unit may include a microfluidic inlet microchannel. The system holds promise in municipal water purification among other applications.
Abstract translation: 公开了一种微分离系统，其可用于分离分散在基础流体例如水中的固体颗粒。 微型澄清系统包括多个微流体分离器单元，其设置在流体入口歧管和流体出口歧管之间并与其流体连通。 微量澄清系统执行流体的层状流动，结果，在与每个微流体分离器单元相关联的收集室内增强颗粒沉降的速率，并且净化的流体必须通过该速率。 每个微流体分离器单元包括设置在微流体收集室和流体出口歧管之间的微流体出口微通道，以及构造成在收集室清洗循环期间从收集室中清除微粒的气液冲洗模块。 任选地，每个微流体分离器单元可以包括微流体入口微通道。 该系统在城市净水中的应用前景广阔。
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