公开(公告)号：US4803171A

公开(公告)日：1989-02-07

申请号：US940500

申请日：1986-12-11

Applicant: Manfred Baier ,  Klaus P. Kaspar ,  Rainer Schafer ,  Ulrich Trager ,  Siegfried Notzel

Inventor： Manfred Baier ,  Klaus P. Kaspar ,  Rainer Schafer ,  Ulrich Trager ,  Siegfried Notzel

IPC: G01N33/548 ,  G01N33/52 ,  G01N33/543 ,  G01N33/544 ,  G01N33/545 ,  G01N33/53

CPC classification number: G01N33/545 ,  G01N33/544 ,  Y10S435/805 ,  Y10S436/81

Abstract: The present invention provides a process for the preparation of a reagent paper for immunological analysis, wherein a fiber fleece of a cellulose/synthetic fiber mixture, in which the weight ratio of cellulose/synthetic fiber is 1 to 90/99 to 10, is activated by treatment with periodate, the so activated fiber fleece is loaded with an acid-treated protein and non-bound protein is removed.The present invention also provides a reagent paper for immunological analysis, wherein it comprises a fiber fleece of a cellulose/synthetic fiber mixture, in which the weight ratio of cellulose/synthetic fiber is from 1 to 90/99 to 10.Furthermore, the present invention is concerned with the use of a fiber fleece of a cellulose/synthetic fiber mixture, wherein the weight ratio of cellulose/synthetic fiber is 90 to 1/10 to 99, as reagent carrier for heterogeneous immunological analysis.

Abstract translation: 本发明提供一种制备用于免疫学分析的试剂纸的方法，其中纤维素/合成纤维混合物的纤维绒毛纤维素/合成纤维的重量比为1至90/99至10，被激活 通过用高碘酸盐处理，如此活化的纤维羊毛装载有酸处理的蛋白质，并且去除非结合蛋白质。 本发明还提供了一种用于免疫学分析的试剂纸，其中纤维素/合成纤维混合物的纤维绒毛的纤维素/合成纤维的重量比为1〜90/99〜10。此外，本发明 本发明涉及使用纤维素/合成纤维混合物的纤维绒，其中纤维素/合成纤维的重量比为90至1/10至99作为用于异质免疫分析的试剂载体。

公开(公告)号：US4415700A

公开(公告)日：1983-11-15

申请号：US331114

申请日：1981-12-16

Applicant: Hans-Georg Batz ,  Paul Tanswell ,  Manfred Baier ,  Karel Bouchal ,  Jaroslav Kalal ,  Frantisek Svec ,  Eva Zurkova

Inventor： Hans-Georg Batz ,  Paul Tanswell ,  Manfred Baier ,  Karel Bouchal ,  Jaroslav Kalal ,  Frantisek Svec ,  Eva Zurkova

IPC: A61K39/44 ,  C08F2/22 ,  C12N11/08 ,  G01N33/543 ,  G01N33/74 ,  C08L33/00 ,  C08F20/32 ,  C08L37/00 ,  G01N33/54

CPC classification number: A61K39/44 ,  C08F2/22 ,  C12N11/08 ,  G01N33/54313 ,  G01N33/74

Abstract: Hydrophilic latex particles consisting of a homo- or co-polymer of monomers which are sparingly soluble in water, which hydrophilic latex particles can be prepared by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without an addition of an emulsifier, stabilizer or wetting agent. A process for the preparation of these hydrophilic latex particles, wherein a monomer which is sparingly soluble in water or several monomers which are sparingly soluble in water are dispersed in water and, with the exclusion of oxygen, for example in an inert atmosphere, are homo- or co-polymerized by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without any addition of an emulsifier, stabilizer or wetting agent.A diagnostic agent containing these hydrophilic latex particles as carrier and biologically and/or immunologically active substances covalently bound to this carrier either directly or via a coupling agent as a bridge.

Abstract translation: 亲水胶乳颗粒由单体的均聚物或共聚物组成，其单独溶于水，该亲水胶乳颗粒可以通过在水溶性自由基形成引发剂存在下的乳液聚合制备，但不加入 乳化剂，稳定剂或润湿剂。 制备这些亲水胶乳颗粒的方法，其中微溶于水的单体或少量微溶于水的单体分散在水中，并且除了氧以外，例如在惰性气氛中是均一的 - 或者在水溶性自由基形成引发剂的存在下通过乳液聚合共聚，但不加入乳化剂，稳定剂或润湿剂。 包含这些亲水性胶乳颗粒作为载体的诊断剂，以及直接或通过偶联剂作为桥接共价结合到该载体的生物和/或免疫活性物质。

公开(公告)号：US5118609A

公开(公告)日：1992-06-02

申请号：US648685

申请日：1991-01-31

Applicant: Manfred Baier ,  Helmut Jering ,  Rolf Lerch ,  Dieter Mangold ,  Ellen Mossner ,  Gunter Pappert ,  Siegfried Notzel

Inventor： Manfred Baier ,  Helmut Jering ,  Rolf Lerch ,  Dieter Mangold ,  Ellen Mossner ,  Gunter Pappert ,  Siegfried Notzel

IPC: C07K1/16 ,  C07K16/00 ,  C07K17/10 ,  C12Q1/00 ,  C12Q1/34 ,  D04H1/54 ,  D04H1/58 ,  D21H11/12 ,  D21H13/08 ,  D21H13/16 ,  D21H13/24 ,  D21H13/26 ,  D21H17/34 ,  D21H17/36 ,  D21H17/37 ,  D21H17/39 ,  G01N33/545 ,  G01N33/548

CPC classification number: D21H17/34 ,  G01N33/545 ,  D21H11/12 ,  D21H13/08 ,  D21H13/16 ,  D21H13/24 ,  D21H13/26 ,  D21H17/36 ,  D21H17/37 ,  D21H17/39 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S530/814 ,  Y10S530/815

Abstract: A carrier fleece is prepared for use as reagent carrier from which reagents can be dissolved in as assay such as immunological analysis. The carrier fleece contains from 5 to 60% by weight of cellulose-containing fibers, from 40 to 95% by weight of polyester or polyamide polymer fibers or a combination thereof and from 5 to 30% by weight of the fibers of an organic binding agent which has a hydroxyl or an ester group or a combination thereof. In an immunological analysis, the carrier fleece is impregnated with an immunologically active agent such as a beta-galactosidase conjugate and then introduced into a solution of a sample containing an immunologically active substance to be analyzed. The immunologically active agent is eluted into the sample solution and the presence of the immunologically active substance in the sample is determined.

Abstract translation: 制备载体羊毛作为试剂载体，试剂可以作为试剂溶解，如免疫分析。 载体绒毛含有5至60重量％的含纤维素的纤维，40至95重量％的聚酯或聚酰胺聚合物纤维或其组合，和5至30重量％的有机粘合剂的纤维 其具有羟基或酯基或其组合。 在免疫学分析中，载体羊毛用免疫活性剂例如β-半乳糖苷酶缀合物浸渍，然后引入含有待分析的免疫活性物质的样品的溶液中。 将免疫活性剂洗脱到样品溶液中，并测定样品中免疫活性物质的存在。

公开(公告)号：US4985204A

公开(公告)日：1991-01-15

申请号：US159253

申请日：1988-02-23

Applicant: Sigmar Klose ,  Klaus Erler ,  Wolfgang Uhl ,  Manfred Baier

Inventor： Sigmar Klose ,  Klaus Erler ,  Wolfgang Uhl ,  Manfred Baier

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502 ,  G01N33/54366

Abstract: The present invention provides a device for carrying out a heterogeneous reaction for the determination of a component of a sample liquid on a first capillary action carrier present in a measurement chamber, to which carrier adheres at least one non-soluble reagent, wherein at least one soluble reagent is present on a second capillary action carrier in a first pre-chamber, which carrier is in capillary contact with the capillary action carrier in the measurement chamber, which first pre-chamber is connected via a first capillary with a first application chamber to be filled from outside through a filling opening and the measurement chamber is also connected with a waste chamber by a capillary arrangement through which can only flow a liquid under a predetermined gravitational force into the measurement chamber.

Abstract translation: 本发明提供一种用于进行非均相反应的装置，用于确定存在于测量室中的第一毛细作用载体上的样品液体的组分，载体粘附至至少一种不溶性试剂，其中至少一种 可溶性试剂存在于第一预处理室中的第二毛细管作用载体上，该第一预处理室与测量室中的毛细管作用载体毛细接触，该第一预先室经由第一毛细管与第一施加室连接， 从外部通过填充开口填充，并且测量室还通过毛细管装置与废物室连接，通过该毛细管装置，只能将液体以预定重力流动到测量室中。

公开(公告)号：US4670383A

公开(公告)日：1987-06-02

申请号：US775596

申请日：1985-09-13

Applicant: Manfred Baier ,  Helmut Jering ,  Sigmar Klose

Inventor： Manfred Baier ,  Helmut Jering ,  Sigmar Klose

IPC: G01N33/541 ,  G01N33/543 ,  G01N33/563 ,  G01N33/564 ,  G01N33/94 ,  G01N33/53 ,  G01N33/537

CPC classification number: G01N33/564 ,  G01N33/541 ,  G01N33/54306 ,  G01N33/563 ,  G01N33/9453 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/824

Abstract: This invention describes a process for immuno-chemical quantitative determination of immunologically active substances. The method involves a first incubation of a sample containing the active substance with a labelled binder, which contains an antibody or antibody fragment. After complexing has taken place, solid phase bound active substance identical to the substance being quantitatively determined is added. The solid phase bound substance binds with free binder, and the solid and liquid phases are separated. A second antibody which is specific either to antibody or the solid phase antibody-substance complex is then added to the liquid phase. This second antibody is non cross-reactive with individual complex components. The amount of labelled first antibody bound to second antibody is then determined.

Abstract translation: 本发明描述了免疫学定量测定免疫活性物质的方法。 该方法包括将含有活性物质的样品与含有抗体或抗体片段的标记的粘合剂进行第一次孵育。 发生络合后，加入与待定量物质相同的固相结合活性物质。 固相结合的物质与游离的粘合剂结合，并分离固相和液相。 然后将与抗体或固相抗体 - 物质复合物特异性的第二抗体加入到液相中。 该第二抗体与单个复合组分是非交叉反应的。 然后测定与第二抗体结合的标记的第一抗体的量。

公开(公告)号：US4538594A

公开(公告)日：1985-09-03

申请号：US555155

申请日：1983-11-25

Applicant: Manfred Boebel ,  Manfred Baier ,  Gerhard Buess

Inventor： Manfred Boebel ,  Manfred Baier ,  Gerhard Buess

IPC: A61B1/31 ,  A61B17/34 ,  A61B1/00

CPC classification number: A61B1/31 ,  A61B2017/00296 ,  A61B2017/3445 ,  A61B2017/3449 ,  A61B2017/3452 ,  A61B2017/3466 ,  A61B2017/347

Abstract: The rectoscope comprises a short, wide tube having a proximal coupling housing or a coupling housing which may be coupled at its distal side to a tube of optional length and width. The coupling housing may be coupled at its proximal side to a mandrel or an instrument carrier which is equipped with axially parallel through-bores, for sealed traversal by an optical system and auxiliary instruments. The tube is rigidly connected to an operating table or the like by means of a handle. Passages through which an inert gas may be introduced into the rectum under pressure lead into the rectoscope through the handle or separately. Vapors impeding the view which are developed in the rectal cavity during a coagulating operation may either be discharged direct into the atmosphere via a separate passage or retained in a reception vessel, together with quantities of fluid or body secretions drawn off by suction via a flushing and suction tube inserted into the rectal cavity, by means of a filter preconnected to a gas return pipe.

Abstract translation: 该直肠镜包括短的宽的管，其具有近端联接外壳或联接外壳，其可以在其远侧连接到任选的长度和宽度的管。 耦合壳体可以在其近侧耦合到心轴或仪器载体，该心轴或仪器载体配备有轴向平行的通孔，用于通过光学系统和辅助仪器进行密封穿越。 管通过手柄刚性地连接到操作台等上。 在压力下可以将惰性气体引入直肠的通道通过手柄或分开导入到直肠镜中。 妨碍在凝血操作期间在直肠腔中形成的视野的蒸气可以通过单独的通道直接排放到大气中或保留在接收容器中，以及通过冲洗通过抽吸抽出的流体或身体分泌物的量， 吸入管通过预先连接到气体返回管的过滤器插入直肠腔中。

公开(公告)号：US4538131A

公开(公告)日：1985-08-27

申请号：US556645

申请日：1983-11-30

Applicant: Manfred Baier ,  Andreas Rascher

Inventor： Manfred Baier ,  Andreas Rascher

IPC: H01F30/08 ,  H01F27/08

CPC classification number: H01F37/005 ,  Y10S174/24

Abstract: An axially symmetric air-core choke coil for high voltage applications. The coil includes a plurality of radially concentric, helically wound layers of windings. Non-insulated wire cable is used to produce each winding. Therefore, adjacent turns of each winding, as well as adjacent layers are spaced from one another. Separation between adjacent turns of each layer is provided through longitudinally extending, non-conductive, strips which are circumferentially spaced around the outer periphery of each winding layer. The strips are folded radially inward at the open spaces between turns. The layers are separated by a plurality of longitudinally extending non-conductive bars. The bars can be positioned to overlap the strips. Numerous air gaps are thereby defined between adjacent turns and adjacent layers which allow air to easily flow in a radial direction into the center of the air-core coil. A screen is provided at one axial end of the air-core coil to block the axial flow of air through the center of the air-core and to direct the axial air flow over the inner periphery of the air-core. This creates a Bernulli effect which reduces the air pressure within the air-core so that the radial air flow is substantially increased. Means are provided for axially compressing the windings of the coil to increase its mechanical strength to withstand disruptive forces which develop during short-circuit conditions.

Abstract translation: 用于高压应用的轴对称空心扼流线圈。 线圈包括多个径向同心的螺旋缠绕的绕组层。 使用非绝缘线缆来生产每个绕组。 因此，每个绕组的相邻匝以及相邻的层彼此间隔开。 每个层的相邻匝之间的分离通过沿着每个绕组层的外周围周向隔开的纵向延伸的非导电条带来提供。 条带在匝之间的开放空间处径向向内折叠。 这些层被多个纵向延伸的非导电棒隔开。 条可以定位成与条重叠。 因此，在相邻匝和相邻层之间限定许多气隙，这允许空气容易地沿径向流动到空心线圈的中心。 在空芯线圈的一个轴向端部设置有屏蔽件，以阻挡空气通过空芯的中心的轴向流动并且引导轴向气流流过空气芯的内周。 这产生伯努利效应，其降低空芯内的空气压力，使得径向气流显着增加。 提供用于轴向压缩线圈绕组的装置以增加其机械强度以承受在短路条件下产生的破坏力。

公开(公告)号：US4966578A

公开(公告)日：1990-10-30

申请号：US201936

申请日：1988-06-03

Applicant: Manfred Baier ,  Roland Schafer

Inventor： Manfred Baier ,  Roland Schafer

IPC: A61M13/00

CPC classification number: A61M13/003

Abstract: In an apparatus for the insufflation of gas into a body cavity the dynamic pressure of the gas flow conducted to the body cavity and the static intra-abdominal pressure in the body cavity are detected with at least one measuring transducer. The electrical output signal of the measuring transducer detecting the pressure is converted by difference formation with a compensation signal, which substantially takes into account the resistance to flow of the instrument conducting the gas into the body cavity, into a difference signal corresponding to the static intra-abdominal pressure. With this signal a control circuit for the setting of the desired pressure value in the body cavity is controlled, in which respect the compensation signal in each case at the start of the insufflation is generated from the output signal of the relevant measuring transducer and is stored in a store and upon gas flow the stored compensation signal is fed to the one input and the output signal of the measuring transducer is fed to the other input of an operational amplifier for the formation of the difference signal, whilst the store at the input store is separated electrically from the measuring transducer by way of a switch.

Abstract translation: 在用于将气体吹入体腔的装置中，用至少一个测量传感器检测传导到体腔的气流的动态压力和体腔中的静态腹内压。 检测压力的测量传感器的电输出信号通过差分形成被转换成补偿信号，该补偿信号基本上考虑了将气体传导到体腔中的仪器的流动阻力变为对应于静态内部的差分信号 腹部压力。 利用该信号，控制用于设定体腔中所需压力值的控制电路，在这方面，在吹扫开始时的每种情况下的补偿信号都是根据相关测量传感器的输出信号产生的，并被存储 在存储器中并且在气体流动时，存储的补偿信号被馈送到一个输入，并且测量变换器的输出信号被馈送到运算放大器的另一个输入端，用于形成差分信号，而存储在输入存储器 通过开关与测量传感器电隔离。

公开(公告)号：US4624930A

公开(公告)日：1986-11-25

申请号：US508258

申请日：1983-06-27

Applicant: Paul Tanswell ,  Manfred Baier ,  Helmut Lenz

Inventor： Paul Tanswell ,  Manfred Baier ,  Helmut Lenz

IPC: G01N33/541 ,  G01N33/543 ,  G01N33/563 ,  G01N33/78

CPC classification number: G01N33/78 ,  G01N33/54306 ,  G01N33/563 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/813 ,  Y10S436/817 ,  Y10S436/823 ,  Y10S436/824

Abstract: A process for determining the presence of polyvalent antigens by incubation with three receptors is presented. In addition, a kit for carrying out this process is provided as well. One of said receptors is bound to a solid support and the other two, in solution, derive from the same animal species.

Abstract translation: 提出了通过与三种受体温育来测定多价抗原的存在的方法。 此外，还提供了用于执行该过程的套件。 所述受体之一与固体支持物结合，另外两种在溶液中衍生自相同的动物物种。

公开(公告)号：US4484585A

公开(公告)日：1984-11-27

申请号：US414299

申请日：1982-09-02

Applicant: Manfred Baier

Inventor： Manfred Baier

IPC: A61B5/22 ,  A61M25/00 ,  A61B5/10

CPC classification number: A61M25/003 ,  A61B5/227 ,  A61M25/0023 ,  A61M25/007 ,  A61M2025/0037

Abstract: This invention relates to catheters for measuring the pressure along the length of a patient's urethra, of the kind having a closed distal end and provided at a distance from said distal end with a lateral outlet for a fluid to be fed in at a constant rate of flow through a passage arranged for connection to a measuring instrument.According to the invention, the lateral catheter outlet is formed by an annular gap extending in a plane at right angles to the longitudinal axis of the catheter and into which opens the supply passage for the fluid.Advantageously, the catheter is transversely divided into two parts constituting distal and proximal sections having mutually opposed terminal areas. These terminal areas are connected by a rigid bridging member to form the annular gap, which latter for example has a width of advantageously between 0.2 and 0.5 mm.

Abstract translation: 本发明涉及用于测量沿着患者尿道长度的压力的导管，该导管具有封闭的远端并且设置在距离所述远端一定距离的位置，具有用于以恒定速率进给的流体的侧向出口 流过布置成连接到测量仪器的通道。 根据本发明，侧向导管出口由在与导管的纵向轴线成直角的平面中延伸的环形间隙形成，并向其中打开用于流体的供应通道。 有利地，导管被横向分成两部分，构成具有相互相对的末端区域的远侧和近端部分。 这些端子区域由刚性桥接构件连接以形成环形间隙，后者例如具有0.2至0.5mm之间的宽度。