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公开(公告)号：US20230151440A1
公开(公告)日：2023-05-18
申请号：US17810696
申请日：2022-07-05
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12Q1/70 , C12Q1/68 , C12Q1/6851
CPC classification number: C12Q1/701 , C12Q1/703 , C12Q1/68 , C12Q1/6851 , Y10T436/143333
Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US11414716B2
公开(公告)日：2022-08-16
申请号：US16827590
申请日：2020-03-23
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12P19/34 , C12Q1/70 , C12Q1/68 , C12Q1/6851
Abstract: Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US20200060644A1
公开(公告)日：2020-02-27
申请号：US16547544
申请日：2019-08-21
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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公开(公告)号：US10376892B2
公开(公告)日：2019-08-13
申请号：US15360691
申请日：2016-11-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
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公开(公告)号：US10068051B2
公开(公告)日：2018-09-04
申请号：US14451876
申请日：2014-08-05
Applicant: California Institute of Technology
Inventor： Emil Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , G06F19/20 , G06F19/12 , C12Q1/68 , G01N21/64 , C12Q1/6825 , C12Q1/6851 , G06F19/24 , G06F17/10 , G06F17/11
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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Patent Agency Ranking
16.发明授权公开(公告)号：US09533308B2
公开(公告)日：2017-01-03
申请号：US13763352
申请日：2013-02-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Samson Chen , Axel Scherer , Christopher I. Walker
CPC classification number: B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0893 , B01L2300/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , C12Q1/686 , H05K1/0212 , H05K1/0272 , H05K1/028 , H05K3/46 , H05K3/4697 , Y10T29/49124
Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。
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公开(公告)号：US08841712B2
公开(公告)日：2014-09-23
申请号：US13852480
申请日：2013-03-28
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: H01L29/76 , G01N27/327 , H01L29/66 , H01L29/78
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.
Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。
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公开(公告)号：US20130207639A1
公开(公告)日：2013-08-15
申请号：US13764612
申请日：2013-02-11
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Chieh-Feng Chang , Akram Sarwat Sadek , Axel Scherer , Raymond Jimenez
IPC: G01R19/00
CPC classification number: G01R19/00 , A61B5/0031 , A61B5/04001 , A61B2560/0214 , A61B2562/0209 , A61B2562/0233 , A61B2562/164 , A61B2562/166 , A61B2562/223
Abstract: A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described.
Abstract translation: 一种半导体衬底上的电压感测装置，包括一个或多个包括金属触点的输入端，包括激光发射器的输出端，将输入电连接到输出端的电路; 和电源模块。 还描述了制造该装置的方法。
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公开(公告)号：US11866768B2
公开(公告)日：2024-01-09
申请号：US16937464
申请日：2020-07-23
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , C12Q1/6825 , G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , G06F17/10 , G06F17/11 , G16B40/00
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10 , G06F17/11 , G16B40/00 , Y02A50/30 , C12Q1/6851 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US11660066B2
公开(公告)日：2023-05-30
申请号：US16547544
申请日：2019-08-21
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: Some implementations of the disclosure are directed to an ultrasound measurement device including: multiple ultrasound sensors to capture tomographical information of a physiological structure, each ultrasound sensor comprising a transducer having a respective resonant frequency, where each transducer has a frequency response that partially overlaps with a frequency response of another transducer; and a processing device to control and process measurements made by the ultrasound sensors. The device may be incorporated in an adhesive substrate configured to be adhered to a patient's skin in alignment with an artery of the patient. The processing device may use the multiple ultrasound sensors to compute the mean arterial pressure through the artery by performing operations of: measuring a circumference of the artery using the multiple ultrasound sensors; measuring a blood flow velocity using the same ultrasound sensors; and computing the mean arterial pressure using the measured arterial circumference and blood flow velocity.
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