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    METHOD AND DEVICE FOR SOLVENT EVAPORATION FROM A LIQUID FEED
    14.
    发明申请
    METHOD AND DEVICE FOR SOLVENT EVAPORATION FROM A LIQUID FEED 有权
    用于从液体进料的溶剂蒸发的方法和装置

    公开(公告)号：US20150075300A1

    公开(公告)日：2015-03-19

    申请号：US14384943

    申请日：2013-03-12

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Thomas Hankemeier ,  Jan-Willem Schoonen ,  Heiko Jan Van Der Linden ,  Paul Vulto

    IPC: G01N30/12 ,  G01N30/62 ,  G01N30/46

    CPC classification number: G01N30/12 ,  B01D1/00 ,  G01N1/2214 ,  G01N1/2273 ,  G01N1/24 ,  G01N1/4022 ,  G01N1/405 ,  G01N30/463 ,  G01N30/62 ,  G01N2001/2223 ,  G01N2001/4027 ,  G01N2030/027 ,  G01N2030/126

    Abstract: The present invention relates to a device and an arrangement for selective solvent evaporation from a liquid feed, the feed comprising one or more components diluted in at least a first solvent or a solvent blend, comprising: a) a first tubular vessel having a distal end or a channel suitable for the formation of a droplet of a first volume, at an inflow rate n, at the tip or in the lumen of the tubular vessel, and b) means for subjecting the droplet to a solvent removal step at an evaporation rate r2 to evaporate at least part of the first solvent or solvent blend, to accumulate the components in the feed in the droplet during the evaporation process at an accumulation rate r3, to obtain a concentrated feed volume in a concentrated droplet, wherein the evaporation and/or inflow rates are continuously adjusted to achieve a desired accumulation rate. The invention further relates to a method for selective solvent removal from an analyte mixture obtained in a chromatographic separation process.

    Abstract translation: 本发明涉及一种用于从液体进料选择性溶剂蒸发的装置和装置，所述进料包含在至少第一溶剂或溶剂共混物中稀释的一种或多种组分，所述组分包括：a）第一管状容器，其具有远端 或适于在管状容器的尖端或内腔中以流入速率n形成第一体积的液滴的通道，以及b）用于使液滴以蒸发速率进行溶剂去除步骤的装置 r2蒸发至少部分第一溶剂或溶剂共混物，以在堆积速率r3的蒸发过程中将液体中的组分积聚在液滴中，以获得浓缩液滴中的浓缩进料体积，其中蒸发和/ 或流入速率连续调整以达到所需的累积率。 本发明还涉及从色谱分离过程中获得的分析物混合物中选择性溶剂去除的方法。

    ANTIBIOTIC NATURAL PRODUCT ANALOGUES
    16.
    发明公开
    ANTIBIOTIC NATURAL PRODUCT ANALOGUES 审中-公开

    公开(公告)号：US20240140991A1

    公开(公告)日：2024-05-02

    申请号：US18263335

    申请日：2021-11-30

    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  UNIVERSITEIT LEIDEN

    Inventor： Stephen COCHRANE ,  Ross BALLANTINE ,  Nathaniel MARTIN ,  Karol AL AYED ,  Michael HOEKSTRA ,  Sofia Denise Zamarbide LOSADA

    IPC: C07K7/64 ,  A61P31/04 ,  C07K7/08

    CPC classification number: C07K7/64 ,  A61P31/04 ,  C07K7/08 ,  A61K38/00

    Abstract: A compound of formula (I) or formula (II) including tautomeric or stereochemically isomeric forms thereof, wherein: R1 represents C1-20 alkyl, C2-20 alkenyl, C6-20 aryl, or C4-20 heterocyclyl, each optionally substituted with one or more Y groups, R2a to R2l each independently represents H, C1-10 alkyl, C2-10 alkenyl, C6-12 aryl, or C4-12 heterocyclyl, each optionally substituted with one or more Y groups, R3 represents H, C1-10 alkyl, C2-10 alkenyl, C6-12 aryl, or C4-12 heterocyclyl, each optionally substituted with one or more Y groups, X represents NH, S or O, each Y independently represents cyano, halogen, N3, —C(O)RZ, —C(0)0Rz, —0C(0)Rz, —C(0)NHZ, —NHC(O)Rz, —NHC(0)NHRZ, —NHC(NH)NHRZ, —NCH(0)0Rz, -0C(0)NHRz, -0S(0)2RZ, —S(0)2NHRZ, —NHS(0)2RZ, —SRZ, —NRZZ or —ORz and each Rz independently represents H, C1-10 alkyl, C2-10 alkenyl, C6-10 aryl, or C4-10 heterocyclyl; or an N-oxide thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof; and wherein formula (I) excludes laterocidine, wherein formula (I) excludes relacidine A, and wherein formula (I) excludes relacidine B. A pharmaceutical composition comprising the compound. The compounds and pharmaceutical compositions are useful as antibiotics.

    Two-phase electroextraction from moving phases
    18.
    发明授权
    Two-phase electroextraction from moving phases 有权

    公开(公告)号：US11504645B2

    公开(公告)日：2022-11-22

    申请号：US14898813

    申请日：2014-06-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Jan-Willem Schoonen ,  Peter Lindenburg ,  Vincent Van Duinen ,  Amar Oedit ,  Paul Vulto ,  Thomas Hankemeier

    IPC: B01D11/04 ,  G01N1/40 ,  B01L3/00

    Abstract: The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode; and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode.

    METHOD FOR MATRIX EFFECT CORRECTION IN QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF ANALYTES IN COMPLEX MATRICES
    19.
    发明申请
    METHOD FOR MATRIX EFFECT CORRECTION IN QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF ANALYTES IN COMPLEX MATRICES 有权

    公开(公告)号：US20220003726A1

    公开(公告)日：2022-01-06

    申请号：US17293978

    申请日：2019-11-18

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Thomas HANKEMEIER ,  Anne Charlotte DUBBELMAN ,  Amy C. HARMS ,  Oskar GONZÁLEZ

    IPC: G01N30/72 ,  G01N30/86 ,  G01N30/04

    Abstract: The present invention relates to a method for quantifying one or more analytes in a sample by an analysis system comprising a separation unit (LC column), a means of adding a solution post-column (Connector), and a detection unit comprising a mass spectrometer coupled through an ionization source, the method comprising: ⋅ (i) inducing matrix effect on the analytes in the sample and on the post-column infused internal standards (PCI-ISs); ⋅ (ii) matching one or more post-column infused internal standard (PCI-IS) to each analyte that best matches the analyte's response to the matrix effect, and ⋅ (iii) storing the analyte-matched PCI-IS identification and, optionally, associated response data in a library; and ⋅ (iv) applying the analyte-matched PCI-IS to the analyte in other samples to correct the analyte peak responses for the matrix effect during ionization and to obtain (absolute) quantitation of the analyte using the response data.

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