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公开(公告)号：US20220064231A1
公开(公告)日：2022-03-03
申请号：US17276452
申请日：2019-09-17
Inventor： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
IPC: C07K14/46
Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US20230391839A1
公开(公告)日：2023-12-07
申请号：US18322507
申请日：2023-05-23
Inventor： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
IPC: C07K14/46
Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US20190194217A1
公开(公告)日：2019-06-27
申请号：US15578991
申请日：2016-06-03
Applicant: Universiteit Leiden
Inventor： Changsheng Wu , Young-Hae Choi , Gilles Philippus van Wezel
IPC: C07D491/107 , C12P17/04 , A01N43/38
Abstract: The invention is among others concerned with novel polyketides, their method of production, purification and use. The method can entail providing a bacterium that synthesizes the compound.
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Patent Agency Ranking
公开(公告)号：US12037372B2
公开(公告)日：2024-07-16
申请号：US18322507
申请日：2023-05-23
Inventor： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US20160331708A1
公开(公告)日：2016-11-17
申请号：US15110936
申请日：2015-01-09
Applicant: UNIVERSITEIT LEIDEN
Inventor： Hye Kyong Kim , Anne van der Meij , Robert Verpoorte , Young Hae Choi , Gilles Philippus van Wezel
IPC: A61K31/196 , A61K31/7036 , A61K31/165 , A61K31/7056 , A61K31/43 , A61K31/545 , A61K38/14 , A61K38/08 , A61K31/496 , C12P19/54 , C12P19/52 , C12P19/48 , C12P13/02 , C12P37/00 , A61K35/74
CPC classification number: A61K31/196 , A61K31/00 , A61K31/165 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/7036 , A61K31/7056 , A61K35/74 , A61K38/08 , A61K38/14 , C12P13/02 , C12P19/485 , C12P19/52 , C12P19/54 , C12P37/00 , A61K2300/00
Abstract: The disclosure provides means and methods for increasing the activity of antibiotics. This enables the use of lower antibiotic dosages and the treatment of multidrug-resistant bacteria.
Abstract translation: 本公开提供了增加抗生素活性的方法和方法。 这使得能够使用较低的抗生素剂量和多药耐药性细菌的治疗。
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公开(公告)号：US11680088B2
公开(公告)日：2023-06-20
申请号：US17276452
申请日：2019-09-17
Inventor： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US10696685B2
公开(公告)日：2020-06-30
申请号：US15578991
申请日：2016-06-03
Applicant: Universiteit Leiden
Inventor： Changsheng Wu , Young-Hae Choi , Gilles Philippus van Wezel
IPC: C07D491/107 , C07D487/04 , C07D491/10 , A01N43/38 , C12P17/04 , A61P31/04 , A61P35/00
Abstract: The invention is among others concerned with novel polyketides, their method of production, purification and use. The method can entail providing a bacterium that synthesizes the compound.
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8.发明申请公开(公告)号：US20190000789A1
公开(公告)日：2019-01-03
申请号：US16065509
申请日：2016-12-23
Applicant: Universiteit Leiden
Inventor： Lizah Tanja van der Aart , Nicole Angelique Lemmens , Willem Jan Bastiaan van Wamel , Gilles Philippus van Wezel
IPC: A61K31/198 , A61K38/14 , C12Q1/02 , A61K45/06
Abstract: The disclosure is related to vancomycin resistance and, in particular, to compositions comprising vancomycin for use in inhibiting growth of a vancomycin-resistant microorganism or for use in treating a subject infected with a vancomycin-resistant pathogen. In one aspect, the disclosure provides a composition comprising vancomycin and d-alanine. The disclosure also provides means and methods for treating a subject infected with a vancomycin-resistant microorganism. The disclosure further provides bacteria with a functionally deactivated gene in the vancomycin-resistance cluster.
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