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公开(公告)号:US10557862B2
公开(公告)日:2020-02-11
申请号:US15145934
申请日:2016-05-04
发明人: Paul Glavina , Jody Ann Tirinato
摘要: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.
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12.
公开(公告)号:US10514379B2
公开(公告)日:2019-12-24
申请号:US15836135
申请日:2017-12-08
发明人: Jing Hua Hu , Antti Leo Oskari Virtanen , Eric Edward Potter , James T. K. Smith , Cary James Miller , John Lewis Emerson Campbell , Adam Roger Moss
IPC分类号: G01N33/543 , G01N33/539 , G01N27/74 , G01N33/68
摘要: The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a first immunosensor including an immobilized layer of capture antibodies configured to bind to a first complex of signal antibodies and cardiac troponin such that a second complex of the first complex and the immobilized layer of capture antibodies is localized on or near the first immunosensor. The device further includes a second immunosensor having a magnetic field disposed locally around the second immunosensor. The magnetic field is configured to attract magnetic beads such that a third complex of the first complex and capture antibodies immobilized on the magnetic beads is localized on or near the second immunosensor sensor.
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13.
公开(公告)号:US10514354B2
公开(公告)日:2019-12-24
申请号:US15285687
申请日:2016-10-05
摘要: The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase.
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公开(公告)号:US10365203B2
公开(公告)日:2019-07-30
申请号:US15487870
申请日:2017-04-14
发明人: David Herzog , Zhizhou Wang , Stephen C. Wardlaw , Min Xie
摘要: A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.
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公开(公告)号:US20190054466A1
公开(公告)日:2019-02-21
申请号:US16104243
申请日:2018-08-17
发明人: Sergey Gershtein
IPC分类号: B01L3/00
摘要: This present invention relates generally to devices, systems, and methods for performing bioimaging at the microscopic scale and, more particularly, to devices and systems including a disposable testing device configured to perform bioimaging at the microscopic scale, and methods of performing the bioimaging using the disposable testing device. In some aspects, a testing device is provided for imaging blood cells in a blood sample. The testing device having a sample entry port for receiving the blood sample; a sample testing conduit fluidically connected to the sample entry port, the sample testing conduit including: (i) a planar member, (ii) a transparent planar member, and (iii) a plurality of spacer elements having an average spacer height and disposed between the planar member and the transparent planar member; and an imager chip forming at least a portion of the planar member.
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公开(公告)号:US20190033331A1
公开(公告)日:2019-01-31
申请号:US16150818
申请日:2018-10-03
IPC分类号: G01N33/86 , G01N33/49 , B01L3/00 , G01N27/416 , G01N27/403
摘要: The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.
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公开(公告)号:US10186174B2
公开(公告)日:2019-01-22
申请号:US15702887
申请日:2017-09-13
发明人: Glenn Martin , Tian-Xian Zhao , Stephen L. Snyder
IPC分类号: G09F3/00 , G01N27/06 , G01N27/327
摘要: Methods and devices for determining device usability, e.g., for point of care assay devices. In one embodiment, the invention is to a method of determining device usability in a sensing device, including the steps of: providing a device comprising a first electrical pad; a second electrical pad; and a first polymer layer contacting at least a portion of the first and the second electrical pads and a second polymer layer contacting the first polymer layer and not the first and second electrical pads; applying a potential across the first and the second electrical pads; measuring an electrical property associated with the first and the second polymer layers; and determining whether the measured electrical property associated with the first and the second polymer layers has exceeded a threshold level associated with the device usability.
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公开(公告)号:US09995744B2
公开(公告)日:2018-06-12
申请号:US14994713
申请日:2016-01-13
发明人: John Lewis Emerson Campbell , Pamela Anne Frank , Meghan Elizabeth Hawkes , Shannon Reishma Lobin , Cary James Miller , Zhen Yang
IPC分类号: G01N33/543 , G01N33/68 , G01N33/53 , G01N33/545
CPC分类号: G01N33/54386 , G01N33/53 , G01N33/5302 , G01N33/543 , G01N33/54313 , G01N33/54353 , G01N33/545 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2333/4712 , G01N2800/324
摘要: The invention relates to compositions and methods for the immunoassay of an analyte of interest. The analyte is detected in an immunoassay using three or more antibodies, where in each antibody specifically binds to a different epitope on the analyte. When the analyte of interest in a clinical marker for an acute disease, the detection of the analyte by immunoassay is a diagnosis of the occurrence of the disease.
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公开(公告)号:US09993817B2
公开(公告)日:2018-06-12
申请号:US15420388
申请日:2017-01-31
发明人: John A. Verrant , John N. Blum , Vu Phan , Kaushal K. Verma , Elise G. Edson
CPC分类号: B01L3/502715 , B01F5/0614 , B01F5/0618 , B01F5/0646 , B01F5/0647 , B01F5/0652 , B01F13/0059 , B01F2005/0632 , B01F2005/0633 , B01F2215/0037 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/0621 , B01L2200/0684 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/168 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , B01L2400/0484 , B01L2400/0487 , B01L2400/0633 , B01L2400/065 , B01L2400/0655 , B01L2400/086
摘要: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.
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公开(公告)号:US20180136200A1
公开(公告)日:2018-05-17
申请号:US15868549
申请日:2018-01-11
发明人: Gary Vandersleen , Pierre Emeric , Paul Wasserman , Narendra Soman , Graham Davis , Cary Miller
CPC分类号: G01N33/5306 , G01N33/48785 , G01N33/49
摘要: The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.
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