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    Pyrrole-3-acetamides
    131.
    发明授权
    Pyrrole-3-acetamides 失效
    吡咯-3-乙酰胺

    公开(公告)号：US4248784A

    公开(公告)日：1981-02-03

    申请号：US772004

    申请日：1977-02-25

    Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

    Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

    IPC: C07D207/32 ,  C07D207/337

    CPC classification number: C07D207/337 ,  Y10S514/927

    Abstract: 1-R.sub.1 -4-R.sub.4 -.alpha.,.alpha.,2,5-Tetramethylpyrrole-3-acetamides, useful as anti-secretory and anti-ulcer agents, are prepared by hydrolysis, in the presence of a dilute mineral acid, of a corresponding 1-R.sub.1 -4-R.sub.4 -.alpha.,.alpha.,2,5-tetramethylpyrrole-3-acetonitrile.

    Abstract translation: 可用作抗分泌和抗溃疡剂的1-R1-4-R4-α，α，2,5-四甲基吡咯-3-乙酰胺通过在稀无机酸存在下水解制备相应的 1-R1-4-R4-α，α2,5-四甲基吡咯-3-乙腈。

    Process for producing thiolcarbamates
    132.
    发明授权
    Process for producing thiolcarbamates 失效
    生产硫代氨基甲酸盐的方法

    公开(公告)号：US4248779A

    公开(公告)日：1981-02-03

    申请号：US948346

    申请日：1978-10-04

    Applicant: Zenichi Sato ,  Fumiya Tabuchi ,  Keiichiro Takagi ,  Yoji Imamiya

    Inventor： Zenichi Sato ,  Fumiya Tabuchi ,  Keiichiro Takagi ,  Yoji Imamiya

    IPC: A01N47/10 ,  C07C67/00 ,  C07C325/00 ,  C07C333/04 ,  C07D295/21 ,  C07C155/03 ,  C07D207/32 ,  C07D295/10 ,  C07D211/06

    CPC classification number: C07D295/21

    Abstract: A thiolcarbamate having the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and respectively represent an alkyl, alkoxy, alkenyl, cycloalkyl, hydroxyalkyl, phenyl or benzyl group and R.sub.1 and R.sub.2 can form a ring by binding each other with or without oxygen atom; and R.sub.3 represents a lower alkyl or benzyl group or a substituted benzyl group having one or two substituent of halogen atom, alkyl, alkoxy, alkylthio, nitro, or cyano group, which comprises reacting carbonyl sulfide with a sec-amine having the formula ##STR2## wherein R.sub.1 and R.sub.2 are defined above, in an aqueous medium and then reacting a halogenated hydrocarbon having the formulaX--R.sub.3 (IV)wherein R.sub.3 is defined above and X represents a halogen atom, in an aqueous medium.

    Abstract translation: 具有式（VI）的硫代氨基甲酸酯其中R 1和R 2相同或不同并分别表示烷基，烷氧基，烯基，环烷基，羟基烷基，苯基或苄基，并且R 1和R 2可以通过彼此结合而形成环 有或没有氧原子; 并且R 3表示低级烷基或苄基或具有一个或两个卤原子，烷基，烷氧基，烷硫基，硝基或氰基取代基的取代苄基，其包括使硫化羰与具有式 （I）其中R 1和R 2如上定义，在水性介质中，然后在水性介质中使具有式X-R3（Ⅳ）的卤代烃，其中R3定义如上，X表示卤素原子。

    1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their production
    134.
    发明授权
    1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their production 失效
    1-烃基 - 吡咯-2-乙酸衍生物及其制备

    公开(公告)号：US4238396A

    公开(公告)日：1980-12-09

    申请号：US963673

    申请日：1978-11-27

    Applicant: Kiyosi Kondo ,  Minoru Suda ,  Daiei Tunemoto

    Inventor： Kiyosi Kondo ,  Minoru Suda ,  Daiei Tunemoto

    IPC: C07D207/32 ,  C07D207/33 ,  C07D207/337 ,  C07D207/34

    CPC classification number: C07D207/33 ,  C07D207/337 ,  C07D207/34

    Abstract: 5-Cyano-1-hydrocarbylpyrrole-2-acetic acid is converted to 5-acyl-1-hydrocarbylpyrrole-2-acetic acid by reaction with a Grignard reagent followed by hydrolysis. The cyano compound, novel per se, is produced by reacting 1-hydrocarbyl-2-(2',2',2'-trihalo-1'-hydroxyethyl)pyrrole with a cyanating reagent under basic conditions. The latter pyrrole is in turn formed by reacting 1-hydrocarbylpyrrole with trihaloacetaldehyde such as chloral, preferably in the presence of added organic acid catalyst.

    Abstract translation: 5-氰基-1-烃基吡咯-2-乙酸通过与格氏试剂反应然后水解转化为5-酰基-1-烃基吡咯-2-乙酸。 氰基化合物本身是通过在碱性条件下使1-烃基-2-（2'，2'，2'-三卤代-1'-羟乙基）吡咯与氰化试剂反应制备的。 后者的吡咯又通过1-烃基吡咯与三卤代乙醛如氯醛反应形成，优选在加入的有机酸催化剂存在下形成。

    Preparation of tertiary heterocyclic amines
    136.
    发明授权
    Preparation of tertiary heterocyclic amines 失效
    叔杂环胺的制备

    公开(公告)号：US4220764A

    公开(公告)日：1980-09-02

    申请号：US971284

    申请日：1978-12-20

    Applicant: Tamotsu Imai

    Inventor： Tamotsu Imai

    IPC: C07D207/32 ,  C07D207/323 ,  C07D211/26 ,  C07D295/023 ,  C07D521/00 ,  C07D295/02

    CPC classification number: C07D207/323 ,  C07D211/26 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/023 ,  Y02P20/582

    Abstract: Tertiary amines may be prepared by reacting an olefinic compound, carbon monoxide, hydrogen and a heterocyclic compound containing at least one nitrogen atom which possesses at least one hydrogen atom in the presence of a rhodium- or ruthenium-containing catalyst at temperatures in the range of from about 50.degree. to about 350.degree. C. and a pressure in the range of from about 10 to about 300 atmospheres. The reaction may be exemplified by reacting undecene, carbon monoxide, hydrogen and morpholine in the presence of rhodium chloride to prepare N-dodecylmorpholine.

    Abstract translation: 叔胺可以通过使烯属化合物，一氧化碳，氢和含有至少一个含有至少一个氢原子的氮原子的杂环化合物在含铑或钌催化剂的存在下，在温度范围为 约50℃至约350℃，压力范围为约10至约300大气压。 该反应可以举例说明，在氯化铑存在下使十一碳烯，一氧化碳，氢和吗啉反应制备N-十二烷基吗啉。

    1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines
    139.
    发明授权
    1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines 失效
    1,2,3,4-四氢吡咯（1,2-A）吡嗪

    公开(公告)号：US4188389A

    公开(公告)日：1980-02-12

    申请号：US957602

    申请日：1978-11-03

    Applicant: Ivo L. Jirkovsky

    Inventor： Ivo L. Jirkovsky

    IPC: C07D207/32 ,  C07D207/325 ,  C07D487/04 ,  A61K31/495

    CPC classification number: C07D207/325 ,  C07D487/04

    Abstract: 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine derivatives characterized by having a lower alkyl, cyclo(lower)alkyl, phenyl or substituted phenyl at position 1 of the nucleus and optionally further substituted at position 2 of the nucleus with a lower alkyl, cyclo(lower)alkyl, phenyl(lower)alkylene or 2-(indole-3-yl)ethyl are disclosed. The derivatives are useful antidepressant agents. Methods for their preparation also are disclosed.

    Abstract translation: 1,2,3,4-四氢吡咯并（1,2-a）吡嗪衍生物，其特征在于在核的位置1具有低级烷基，环（低级）烷基，苯基或取代的苯基，并任选地在 公开了具有低级烷基，环（低级）烷基，苯基（低级）亚烷基或2-（吲哚-3-基）乙基）的核。 衍生物是有用的抗抑郁剂。 还公开了其制备方法。

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