公开(公告)号：US4196296A

公开(公告)日：1980-04-01

申请号：US862944

申请日：1977-12-21

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D307/42 ,  C07D307/46 ,  C07D401/04 ,  C07D403/12 ,  C07D487/10

CPC classification number: C07D307/42 ,  C07C255/00 ,  C07D207/34 ,  C07D209/52 ,  C07D307/46 ,  C07D487/10

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过水解或硫代氢解相应的2,4,5,6-四氢环戊二烯 [c]吡咯-4-碳腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。

公开(公告)号：US4126620A

公开(公告)日：1978-11-21

申请号：US772003

申请日：1977-02-25

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: A61K20060101 ,  A61K31/40 ,  C07C20060101 ,  C07D20060101 ,  C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D209/86 ,  C07D209/94 ,  C07D307/42 ,  C07D307/46 ,  C07D401/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/00 ,  C07D403/06 ,  C07D403/08 ,  C07D405/04 ,  C07D405/10 ,  C07D409/00 ,  C07D409/04 ,  C07D413/00 ,  C07D413/02 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D487/10 ,  C07D491/04 ,  C07D521/00

CPC classification number: C07D307/42 ,  C07D207/34 ,  C07D209/52 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D307/46 ,  C07D487/10 ,  C07D491/04 ,  Y10S514/927

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

公开(公告)号：US4008250A

公开(公告)日：1977-02-15

申请号：US558807

申请日：1975-03-17

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D307/42 ,  C07D307/46 ,  C07D487/10

CPC classification number: C07D307/42 ,  C07C255/00 ,  C07D207/34 ,  C07D209/52 ,  C07D307/46 ,  C07D487/10 ,  Y10S514/925 ,  Y10S514/927

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过水解或硫代氢解相应的2,4,5,6-四氢环戊二烯 [c]吡咯-4-碳腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。

公开(公告)号：US4248784A

公开(公告)日：1981-02-03

申请号：US772004

申请日：1977-02-25

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/32 ,  C07D207/337

CPC classification number: C07D207/337 ,  Y10S514/927

Abstract: 1-R.sub.1 -4-R.sub.4 -.alpha.,.alpha.,2,5-Tetramethylpyrrole-3-acetamides, useful as anti-secretory and anti-ulcer agents, are prepared by hydrolysis, in the presence of a dilute mineral acid, of a corresponding 1-R.sub.1 -4-R.sub.4 -.alpha.,.alpha.,2,5-tetramethylpyrrole-3-acetonitrile.

Abstract translation: 可用作抗分泌和抗溃疡剂的1-R1-4-R4-α，α，2,5-四甲基吡咯-3-乙酰胺通过在稀无机酸存在下水解制备相应的 1-R1-4-R4-α，α2,5-四甲基吡咯-3-乙腈。

公开(公告)号：US4220763A

公开(公告)日：1980-09-02

申请号：US63108

申请日：1979-08-02

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: A61K20060101 ,  A61K31/40 ,  C07C20060101 ,  C07D20060101 ,  C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D209/86 ,  C07D209/94 ,  C07D307/42 ,  C07D307/46 ,  C07D401/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/00 ,  C07D403/06 ,  C07D403/08 ,  C07D405/04 ,  C07D405/10 ,  C07D409/00 ,  C07D409/04 ,  C07D413/00 ,  C07D413/02 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D487/10 ,  C07D491/04 ,  C07D521/00 ,  C07D403/04

CPC classification number: C07D307/42 ,  C07D207/34 ,  C07D209/52 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D307/46 ,  C07D487/10 ,  C07D491/04 ,  Y10S514/927

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过相应的2,4,5,6-四氢环戊二烯并[c ]吡咯-4-腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。

公开(公告)号：US4098797A

公开(公告)日：1978-07-04

申请号：US703949

申请日：1976-07-09

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D307/42 ,  C07D307/46 ,  C07D487/10

CPC classification number: C07D307/42 ,  C07C255/00 ,  C07D207/34 ,  C07D209/52 ,  C07D307/46 ,  C07D487/10 ,  Y10S514/925 ,  Y10S514/927

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxyamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

公开(公告)号：US4000165A

公开(公告)日：1976-12-28

申请号：US614478

申请日：1975-09-18

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D307/42

CPC classification number: C07D307/42

Abstract: 2,5-Di-lower-alkyl-3,4-disubstituted-furans have anti-secretory activity.

公开(公告)号：US4273713A

公开(公告)日：1981-06-16

申请号：US76125

申请日：1979-09-17

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/337 ,  C07D207/34 ,  C07D209/52 ,  C07D307/42 ,  C07D307/46 ,  C07D487/10

CPC classification number: C07D307/42 ,  C07C255/00 ,  C07D207/34 ,  C07D209/52 ,  C07D307/46 ,  C07D487/10

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis of thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过水解相应的2,4,5,6-四氢环戊二烯 [c]吡咯-4-碳腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。

公开(公告)号：US4239687A

公开(公告)日：1980-12-16

申请号：US928456

申请日：1978-07-27

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D307/42 ,  C07D307/46 ,  C07D401/04 ,  C07D487/10 ,  C07D401/02

CPC classification number: C07D307/42 ,  C07C255/00 ,  C07D207/34 ,  C07D209/52 ,  C07D307/46 ,  C07D487/10

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis of thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过相应的2,4,5,6-四氢环戊二烯 [c]吡咯-4-碳腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。

公开(公告)号：US4140854A

公开(公告)日：1979-02-20

申请号：US839328

申请日：1977-10-04

Applicant: Malcolm R. Bell ,  Rudolf Oesterlin

Inventor： Malcolm R. Bell ,  Rudolf Oesterlin

IPC: A61K20060101 ,  A61K31/40 ,  C07C20060101 ,  C07D20060101 ,  C07D207/34 ,  C07D209/02 ,  C07D209/52 ,  C07D209/86 ,  C07D209/94 ,  C07D307/42 ,  C07D307/46 ,  C07D401/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/00 ,  C07D403/06 ,  C07D403/08 ,  C07D405/04 ,  C07D405/10 ,  C07D409/00 ,  C07D409/04 ,  C07D413/00 ,  C07D413/02 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D487/10 ,  C07D491/04 ,  C07D521/00

CPC classification number: C07D307/42 ,  C07D207/34 ,  C07D209/52 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D307/46 ,  C07D487/10 ,  C07D491/04 ,  Y10S514/927

Abstract: 2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

Abstract translation: 2,4,5,6-四氢环戊并[c]吡咯-4-甲酰胺和可用作抗分泌和抗溃疡剂的4-硫代羧酰胺衍生物是通过相应的2,4,5,6-四氢环戊二烯并[c ]吡咯-4-腈，或在硫代甲酰胺的情况下，通过4-甲酰胺与五硫化二磷的反应。