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    Method and device to restore and/or improve nervous system functions by modifying specific nervous system pathways
    131.
    发明授权
    Method and device to restore and/or improve nervous system functions by modifying specific nervous system pathways 有权
    通过修改特定神经系统途径恢复和/或改善神经系统功能的方法和装置

    公开(公告)号：US08862236B2

    公开(公告)日：2014-10-14

    申请号：US13958181

    申请日：2013-08-02

    Applicant: Health Research, Inc.

    Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

    IPC: A61N1/00 ,  A61N1/36

    CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

    Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

    Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

    Neuromodulation using energy-efficient waveforms
    134.
    发明授权
    Neuromodulation using energy-efficient waveforms 有权
    使用节能波形进行神经调节

    公开(公告)号：US08805515B2

    公开(公告)日：2014-08-12

    申请号：US13860686

    申请日：2013-04-11

    Applicant: Intelect Medical, Inc.

    Inventor： Randall York ,  Scott Kokones ,  Keith Carlton ,  Alan Greszler

    IPC: A61N1/00

    CPC classification number: A61N1/36103 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/3615

    Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

    Abstract translation: 活体哺乳动物受试者（例如人类患者）中神经调节的方法。 该方法包括将电信号施加到诸如脑的神经系统中的目标部位，其中电信号包括一系列脉冲。 脉冲包括与对应的矩形波形相比更节能的波形形状。 这种能量效率波形的非限制性实例包括线性增加，线性递减，指数增加，指数减小和高斯波形。 还描述了用于神经调节的装置和用于操作这种装置的软件。

    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY
    135.
    发明申请
    SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 审中-公开
    用于增强或影响神经刺激效能和/或效率的系统和方法

    公开(公告)号：US20140222113A1

    公开(公告)日：2014-08-07

    申请号：US14101189

    申请日：2013-12-09

    Applicant: Advanced Neuromodulation Systems, Inc., d/b/a St. Jude Medical Neuromodulation Division

    Inventor： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC: A61N1/36

    CPC classification number: H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    Abstract: Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    Abstract translation: 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    NERVE STUMP INTERFACE AND AXONAL REGENERATION SYSTEM FOR GENERATING AN ELECTRIC FIELD FOR PROMOTING AND GUIDING AXONAL REGENERATION
    139.
    发明申请
    NERVE STUMP INTERFACE AND AXONAL REGENERATION SYSTEM FOR GENERATING AN ELECTRIC FIELD FOR PROMOTING AND GUIDING AXONAL REGENERATION 有权
    用于产生用于促进和引导轴向再生的电场的神经屏障接口和轴向再生系统

    公开(公告)号：US20140148886A1

    公开(公告)日：2014-05-29

    申请号：US14093351

    申请日：2013-11-29

    Applicant: Agency for Science, Technology and Research

    Inventor： Wei Mong Tsang ,  Tao Sun ,  Minkyu Je ,  Tack Boon Yee

    IPC: A61N1/05

    CPC classification number: A61N1/0551 ,  A61B5/04001 ,  A61N1/326 ,  A61N1/36103 ,  Y10T29/49002

    Abstract: The present invention provides a nerve stump interface for generating an electric field for promoting and guiding axonal regeneration and an electric field assisted axonal regeneration system. The nerve stump interface comprises a sieve having a plurality of holes. A strip is coupled to the sieve. A first electrode is provided at one of the plurality of holes and a second electrode is provided on the strip. The strip is arranged to space the second electrode from the first electrode. The first electrode and the second electrode are for generating the electric field. At least one securing element is provided on a side of the strip to allow that side of the strip to affix against an opposite side of the strip. The present invention also provides a method for assembling the electric field assisted axonal regeneration system.

    Abstract translation: 本发明提供用于产生用于促进和引导轴索再生的电场的神经残端界面和电场辅助轴突再生系统。 神经残端界面包括具有多个孔的筛子。 条带连接到筛子上。 第一电极设置在多个孔中的一个孔中，并且第二电极设置在条带上。 带状物被布置成使第二电极与第一电极间隔开。 第一电极和第二电极用于产生电场。 至少一个固定元件设置在条的一侧上，以允许条的侧面贴在条的相对侧上。 本发明还提供了组装电场辅助轴突再生系统的方法。

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