公开(公告)号：US20160184786A1

公开(公告)日：2016-06-30

申请号：US14830611

申请日：2015-08-19

申请人： Waters Technologies Corporation

发明人： Jose De Corral ,  Neal B. Almeida

IPC分类号： B01F15/02 ,  B01F3/08 ,  G01N30/06 ,  B01F5/06

CPC分类号： B01F15/0243 ,  B01D15/166 ,  B01F3/0861 ,  B01F5/0077 ,  B01F5/0268 ,  B01F5/0602 ,  B01F5/0695 ,  B01F5/0696 ,  G01N30/06 ,  G01N30/34 ,  G01N2030/347

摘要： Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly (100) includes, inter alia, a housing (10), an inlet fitting (40), and a mixer cartridge assembly (60). The housing (10) has a fluid receiving section (16) and a fluid discharge section (18) with an outlet (20) formed therein. A central bore (22) extends between the fluid receiving section (16) and fluid discharge section (18). An inlet fitting (40) is engaged with the housing (10) and has first (42) and second (44) fluid ports formed therein that extend from the fitting exterior to the fluid receiving section (16) of the housing (10). A mixer cartridge assembly (60) is disposed within the central bore (22) of the housing (10) and is positioned between the inlet fitting (40) and the downstream end portion of the housing (10). The mixer cartridge assembly (60) includes a body portion (64), a plurality of spheres disposed within a central mixing chamber (62) formed in the body portion (64), and mechanism for retaining the spheres in the mixing chamber (62).

摘要翻译： 公开了一种用于混合流体（即，气体或液体）的组件，更具体地说，一种精确混合两种或更多种高压流体源并适用于诸如色谱法的应用的组件。 混合器组件（100）尤其包括壳体（10），入口配件（40）和混合器筒组件（60）。 壳体（10）具有在其中形成有出口（20）的流体接收部分（16）和流体排出部分（18）。 中心孔（22）在流体接收部分（16）和流体排放部分（18）之间延伸。 入口配件（40）与壳体（10）接合并且具有形成在其中的第一（42）和第二（44）流体端口，其从配件外部延伸到壳体（10）的流体接收部分（16）。 混合器筒组件（60）设置在壳体（10）的中心孔（22）内并且位于入口配件（40）和壳体（10）的下游端部分之间。 混合器筒组件（60）包括主体部分（64），设置在形成于主体部分（64）中的中心混合室（62）内的多个球体，以及用于将球体保持在混合室（62）中的机构， 。

公开(公告)号：US20160146771A1

公开(公告)日：2016-05-26

申请号：US14891794

申请日：2014-05-16

申请人： NUTRASOURCE DIAGNOSTICS INC. ,  NORDIC NATURALS, INC.

发明人： LIANGHONG LI

IPC分类号： G01N33/03 ,  G01N30/06

CPC分类号： G01N33/03 ,  C11C3/006 ,  G01N30/06 ,  G01N2030/027 ,  G01N2030/8854 ,  G01N2030/8872

摘要： Methods for the detection of spoilage of oils containing unsaturated fatty acids is disclosed. Specific methods include the determination of p-anisidine in oils containing unsaturated fatty acids using high performance liquid chromatography after p-an-isidine is added to the oil containing unsaturated fatty acids, and allowed to react with oxidation products.

摘要翻译： 公开了检测含有不饱和脂肪酸的油的变质的方法。 具体方法包括使用高效液相色谱法测定含有不饱和脂肪酸的油中的对茴香胺，将对氨基异丁酸加入到含有不饱和脂肪酸的油中，并与氧化产物反应。

公开(公告)号：US09347920B2

公开(公告)日：2016-05-24

申请号：US14617258

申请日：2015-02-09

申请人： FLIR DETECTION, INC.

发明人： Dennis Barket, Jr. ,  Garth E. Patterson ,  Mark Gregory ,  Jason Springston

IPC分类号： H01J49/00 ,  G01N30/72 ,  H01J49/02 ,  G01N30/06 ,  G01N1/40 ,  G01N35/00

CPC分类号： G01N30/7206 ,  G01N1/405 ,  G01N30/06 ,  G01N30/722 ,  G01N2035/00326 ,  H01J49/0022 ,  H01J49/02

摘要： Person-portable mass analysis instrumentation configured to perform multidimensional mass analysis is provided. Mass analysis instrumentation can include a housing encompassing components of the instrumentation with the housing of the instrumentation defining a space having a volume of equal to or less than about 100,000 cm3. Instrument assemblies are also provided that can include a housing coupled to an instrument component isolation assembly, wherein the component isolation assembly is isolated from an environment exterior to the housing. Exemplary instrument assemblies can include at least first and second components configured to provide analysis with a housing of the instrument at least partially encompassing the first and second components and the first component being rigidly affixed to the housing. An isolation assembly can also be provided that is rigidly affixed to the second component with the isolation assembly being isolated from received inputs of the housing.

公开(公告)号：US09347919B2

公开(公告)日：2016-05-24

申请号：US14358744

申请日：2012-11-16

申请人： Shimadzu Corporation ,  GL Sciences Incorporation

发明人： Shinji Fukumoto ,  Hiroshi Yamauchi ,  Akira Aono ,  Manabu Shimomura ,  Yoshiyuki Takei ,  Tadashi Mimura ,  Akira Suzuki ,  Masahiro Furuno

IPC分类号： G01N30/06 ,  G01N1/14 ,  G01N1/24 ,  B01D3/34 ,  G01N30/02 ,  G01N1/40 ,  G01N30/72

CPC分类号： G01N30/06 ,  B01D3/346 ,  G01N1/14 ,  G01N1/24 ,  G01N30/7206 ,  G01N2001/4066 ,  G01N2030/025 ,  G01N2030/065

摘要： The present invention provides a method and apparatus for rapidly extracting the analyte existing in the liquid phase in analyzing an analyte “having a large partition coefficient in gas-liquid equilibrium”, “having a high water solubility”, or “having a low olfactory threshold” by a gas-liquid contact extraction method, and further provides, a method and apparatus for unmanned continuous sample introduction of the analyte to a GC or the like for a long time. In the present invention, using a gas-liquid contact extractor to which a sample liquid is continuously introduced from above and a purge gas from beneath, the analyte in the sample liquid is extracted by gas-liquid contact between the sample liquid and the purge gas. A discharge pipe is connected to the bottom of the gas-liquid contact extractor, the pipe having a liquid sump through which the sample liquid is discharged, while blocking the outflow of the purge gas from the liquid sump.

摘要翻译： 本发明提供一种方法和装置，用于在分析“气 - 液平衡分配系数大”，“具有高水溶性”或“具有低嗅觉阈值”的分析物中快速提取存在于液相中的分析物 “，并且还提供了用于将分析物无间连续样品长时间引入GC等的方法和装置。 在本发明中，使用从上方连续引入样品液体的气液接触提取器和来自下方的吹扫气体，通过样品液体和吹扫气体之间的气液接触来提取样品液体中的分析物 。 排气管连接到气 - 液接触提取器的底部，管具有液体槽，样品液通过该液槽排出，同时阻止吹扫气体从液槽中流出。

公开(公告)号：US20160131616A1

公开(公告)日：2016-05-12

申请号：US14901542

申请日：2014-06-23

申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

发明人： Behnusch ATHENSTAEDT

IPC分类号： G01N30/06 ,  G01N30/72 ,  G01N30/54 ,  A61M1/16 ,  A61L2/00

CPC分类号： G01N30/06 ,  A61L2/0023 ,  A61L2/28 ,  A61M1/1654 ,  A61M1/287 ,  B01J20/3204 ,  B01J20/3272 ,  G01N30/54 ,  G01N30/7206 ,  G01N2030/567 ,  Y10T436/24 ,  Y10T436/255

摘要： The present invention relates to a method for determination of pollutants and leachables in dialysis solutions by stir bar sorptive extraction comprising the steps of a. Conditioning of the stir bar coated with a sorptive material b. Stirring the dialysis solution with a coated stir bar c. Desorption of pollutants and leachables from the coated stir bar.

摘要翻译： 本发明涉及通过搅拌棒吸附提取法测定透析溶液中污染物和可浸出物的方法，包括以下步骤：a。 调理用吸附材料涂上的搅拌棒b。 用涂覆的搅拌棒搅拌透析溶液c。 污染物和可浸出物从涂层搅拌棒中解吸。

公开(公告)号：US20160116446A1

公开(公告)日：2016-04-28

申请号：US14787209

申请日：2014-04-23

申请人： SUMITOMO ELECTRIC INDUSTRIES, LTD.

发明人： Takayasu SUGIHARA ,  Yukiharu KAWAHARA ,  Osamu Ohama

IPC分类号： G01N30/06 ,  G01N1/10

CPC分类号： G01N30/06 ,  G01N1/10 ,  G01N1/405 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/085

摘要： An analysis method is provided, by which it is determined whether or not a solution to be-examined contains an organic substance in an amount on the order of 20 mass ppb or less. The analysis method for organic substances in a solution to be examined includes the following steps: a sampling step in which 500 ml or less of a sample solution is taken front a solution to be examined; an adsorption step in which the sample solution is passed through activated carbon 8 so that the organic substance is adsorbed on the activated carbon; an extraction step in which the organic substance is extracted into a hydrophobic solvent; a specimen preparation step in which, a specimen solution is prepared by using the hydrophobic solvent into which the organic substance has been extracted; and an analysis step in which an analysis is performed to determine whether or not the organic substance in an amount of 20 mass ppb or less is contained in the solution to be examined. The activated carbon 8 has a specific surface area of 800 m2/g or more, and the amount of the activated carbon 8 is 0.025 g/ml or more relative to the amount of the sample solution. In the adsorption step, the sample solution is passed at a rate of 7.5 ml/min or less on the discharge side of the activated carbon 8.

摘要翻译： 提供了一种分析方法，通过该方法确定被检查溶液是否含有量为20质量ppmb以下的有机物质。 待检测溶液中有机物质的分析方法包括以下步骤：在待检溶液前面取500ml或更少的样品溶液的取样步骤; 吸附步骤，其中样品溶液通过活性炭8使得有机物质被吸附在活性炭上; 将有机物质萃取到疏水性溶剂中的萃取工序; 试样制备步骤，其中通过使用已经提取有机物质的疏水性溶剂制备样品溶液; 以及分析步骤，其中执行分析以确定待检查溶液中是否含有20质量ppm以下的有机物质。 活性炭8的比表面积为800m 2 / g以上，活性炭8相对于样品溶液的量为0.025g / ml以上。 在吸附工序中，在活性炭8的排出侧以7.5ml /分钟以下的速度通过样品溶液。

公开(公告)号：US20160077062A1

公开(公告)日：2016-03-17

申请号：US14888366

申请日：2014-03-31

申请人： HAMILTON BONADUZ AG

发明人： Klaus LECKEBUSCH ,  Tino OTTE

IPC分类号： G01N30/20 ,  G01N30/06

CPC分类号： G01N30/20 ,  G01N30/06 ,  G01N35/1097 ,  G01N2030/204

摘要： A sample dispenser for an analysis device, in particular for an analysis device working according to the principle of liquid chromatography, in particular high pressure liquid chromatography, or gas chromatography, comprising a sample intake for receiving a sample to be analyzed, an inlet through which an eluent can be supplied, an outlet, and an injection valve arrangement, which can be switched at least from an intake position to an injection position, wherein, at least in the intake position and in the injection position, the inlet is in fluid connection with the outlet to deliver the eluent—if applicable, having the sample added thereto—at least partly to the outlet, wherein, in the intake position, the sample intake is separated from the eluent in a fluid-tight manner, and wherein, in the injection position, the sample in the sample intake can combine with the eluent, wherein the sample dispenser is configured as a disposable component.

摘要翻译： 用于分析装置的样品分配器，特别是用于根据液相色谱原理工作的分析装置，特别是高压液相色谱法或气相色谱法，其包括用于接收待分析样品的样品进样口， 可以提供洗脱液，出口和喷射阀装置，其可以至少从进气位置切换到喷射位置，其中至少在进气位置和喷射位置中，入口处于流体连接 其中出口将至少部分地添加到其上的洗脱液（如果适用的话）输送到出口，其中在进气位置中，样品进口以流体密封的方式与洗脱液分离，并且其中，在 注射位置，样品进样中的样品可以与洗脱液结合，其中样品分配器被配置为一次性部件。

公开(公告)号：US09285347B2

公开(公告)日：2016-03-15

申请号：US13903191

申请日：2013-05-28

申请人： Seiji Satake ,  Tokuo Kasai ,  Akira Sezaki ,  Takeshi Matsubara

发明人： Seiji Satake ,  Tokuo Kasai ,  Akira Sezaki ,  Takeshi Matsubara

IPC分类号： G01N30/06 ,  B01D15/16 ,  G01N30/26 ,  B01D19/00 ,  G01N30/04 ,  G01N30/20 ,  G01N30/24 ,  G01N30/88 ,  B01L3/00 ,  G01N30/32

CPC分类号： G01N30/06 ,  B01D15/16 ,  B01D19/0036 ,  B01D19/0063 ,  B01L3/502723 ,  G01N30/04 ,  G01N30/20 ,  G01N30/24 ,  G01N30/26 ,  G01N2030/322 ,  G01N2030/8822

摘要： A bubble reduction device, chromatography device, bubble reduction method and bubble reduction program capable of reducing bubbles in an eluent. Included are a liquid accommodation portion, a liquid supply apparatus, an air layer formation apparatus, a first channel and an evacuation portion. The liquid accommodation portion accommodates a liquid that is to elute an analysis component from a specimen adsorbed to an adsorption portion. The liquid supply apparatus, by operation of a rod pushing up and polling down, sucks and discharges the liquid through an aperture portion of a tube portion, the aperture portion being oriented upward. The air layer formation apparatus forms an air layer in the tube portion. The first channel connects the liquid supply apparatus with the liquid accommodation portion. The evacuation portion is connected to the first channel via a first switching valve and evacuates the air layer through the first channel.

摘要翻译： 气泡减少装置，色谱装置，气泡还原方法和气泡减少程序，能够减少洗脱液中的气泡。 包括液体容纳部分，液体供应装置，空气层形成装置，第一通道和排气部分。 液体容纳部容纳从吸附到吸附部的试样洗脱分析成分的液体。 液体供给装置通过操作杆推动并向下排列，通过管部的开口部吸引并排出液体，该开口部朝向上方。 空气层形成装置在管部中形成空气层。 第一通道将液体供应装置与液体容纳部分连接。 排气部经由第一切换阀与第一流路连接，将空气层排出第一流路。

公开(公告)号：US09236236B2

公开(公告)日：2016-01-12

申请号：US14333724

申请日：2014-07-17

申请人： Thermo Fisher Scientific Oy

发明人： Robert DeWitte ,  Juhani Siidorov ,  Vesa Nuotio ,  Jukka Saukkonen ,  John Edward Brann, III ,  Terry N. Olney

IPC分类号： H01J49/26 ,  H01J49/10 ,  G01N30/06 ,  G01N30/72 ,  G01N30/86 ,  G01N35/00 ,  G01N35/02 ,  G01N35/08 ,  G01N27/62 ,  H01J49/04 ,  G01N30/88 ,  H01J49/00

CPC分类号： G01N30/7233 ,  G01N27/62 ,  G01N30/06 ,  G01N30/16 ,  G01N30/72 ,  G01N30/8658 ,  G01N30/88 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/026 ,  G01N35/08 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2030/628 ,  G01N2030/8804 ,  G01N2030/8813 ,  G06F19/00 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0409 ,  H01J49/0413 ,  H01J49/0431 ,  H01J49/10 ,  Y10T436/24

摘要： A sample preparation and analysis system. The system includes a housing with a sample preparation station and a sample analysis station positioned within the housing. The sample analysis station is spaced away from the sample preparation station. A transport assembly is configured to move at least one sample within the housing and between the sample preparation station and the sample analysis station.

摘要翻译： 样品制备和分析系统。 该系统包括具有样品制备站和位于壳体内的样品分析站的壳体。 样品分析站与样品制备站隔开。 运输组件被配置为移动壳体内的至少一个样本，并且在样品制备站和样品分析站之间移动。

公开(公告)号：US20150362506A1

公开(公告)日：2015-12-17

申请号：US14760313

申请日：2013-04-24

申请人： LIVZON MABPHARM INC.

发明人： Baoguo ZHU ,  Yucai PENG ,  Jiaming YANG

IPC分类号： G01N33/68 ,  G01N30/72 ,  G01N30/06

CPC分类号： G01N33/6848 ,  G01N30/06 ,  G01N30/7233 ,  G01N33/6854 ,  G01N2030/027 ,  G01N2030/065 ,  G01N2030/067 ,  G01N2030/8831 ,  G01N2440/38 ,  G01N2560/00 ,  Y10T436/24

摘要： The present invention provides a method for determining glycosylation and terminal modifications of immunoglobulin during immunoglobulin purification process, which can simultaneously and rapidly determine glycosylation, N-terminal pyroglutamination and C-terminal de-lysination of immunoglobulin. The method comprises: 1) separating immunoglobulin by using cation-exchange resin, and collecting different components in according to retention time; 2) denaturing the components of immunoglobulin obtained in step 1) with a denaturant, followed by reducing them with a reducing agent, to separate the light chain and heavy chain; 3) separating the light chain and heavy chain of immunoglobulin of step 2) by using reverse phase ultrahigh pressure liquid chromatography; 4) measuring the molecular weights of the light chain and heavy chain obtained in step 3) with mass spectrum; 5) analyzing the chromatographic data obtained in step 3) and the mass spectrometric data obtained in step 4) to determine glycosylation and terminal modifications of said immunoglobulin.

摘要翻译： 本发明提供了一种用于在免疫球蛋白纯化过程中测定免疫球蛋白的糖基化和末端修饰的方法，其可以同时且快速地确定免疫球蛋白的糖基化，N-末端焦谷氨酰胺化和C-末端解离。 该方法包括：1）通过使用阳离子交换树脂分离免疫球蛋白，并根据保留时间收集不同的成分; 2）用变性剂使步骤1）中获得的免疫球蛋白成分变性，然后用还原剂还原，分离轻链和重链; 3）使用反相超高压液相色谱法分离步骤2）免疫球蛋白的轻链和重链; 4）用质谱测量步骤3）中获得的轻链和重链的分子量; 5）分析步骤3）中获得的色谱数据和步骤4）中获得的质谱数据，以确定所述免疫球蛋白的糖基化和末端修饰。